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| Macular Mechanism and Research Status of ω-3 Long-Chain Polyunsaturated FattyAcids in the Treatment of Retinal Diseases |
| Jie Wang, Guoge Han, Quanhong Han |
| Tianjin Eye Hospital, Clinical College of Ophthalmology, Tianjin Medical University, Tianjin 300020, China |
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Abstract Infammation, oxidative stress, pathological neovascularization, and apoptosis of retinal nerve cells play an important role in the development of retinal diseases. They are common pathogenic mechanisms in diseases such as age-related macular degeneration (AMD), retinitis pigmentosa (RP), diabetic retinopathy (DR), and retinopathy of prematurity (ROP). ω-3 long-chain polyunsaturated fatty acids (ω-3 LC-PUFAs), as important components of the retina, have been shown to have anti-infammatory and anti-oxidative stress effects, inhibit neovascularization, and promote neuronal cell survival. ω-3 LC-PUFAs and their derivatives are involved in many processes in the prevention and treatment of retinal diseases, and deeper investigation of their relationship with pathological mechanisms may provide potential targets for treatment. The purpose of this article is to review the therapeutic mechanisms of ω-3 LC-PUFAs and their derivatives in retinal diseases and the current research progress, with the aim of providing new therapeutic directions for retinal diseases with similar pathogenesis.
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Received: 25 January 2022
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| Fund:Youth Project of National Natural Science Foundation of China (81700849); Tianjin Natural Science Foundation Youth Project (18JCQNJC10600) |
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Corresponding Authors:
Quanhong Han, Email: Hanquanhong126@126.com
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| [1] |
. [J]. Chinese Journal of Optometry Ophthalmology and Visual science, 2023, 25(9): 0-. |
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