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Dopamine and myopia |
LI Wen-tao,YANG Zhi-kuan |
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Abstract Numerous studies on form deprived and lens induced myopia models demonstrate that signals in the retina regulate the growth locally within the eye.Dopamine as one of the main neurotransmitters in the retina may play an important role and is likely to become a new drug to slow the progression of myopia.In the first section,this review briefly introduces dopamine,dopaminergic neurons and dopamine receptors in the retina.Then it summarizes the changes in retinal dopamine release in experimental myopia and the mechanism of how dopamine might work.Plenty of evidence indicates dopamine does play an important role in the development of experimental myopia.Even though all the studies are not consistent,most tend to support its preventive effects on myopia.However,the specific mechanism is still unclear and further study remains to be done.
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Received: 21 March 2011
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