眼底血管样条纹并发脉络膜新生血管的临床特征及联合治疗

doi:10.3760/cma.j.issn.1674-845X.2015.03.009

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Abstract

Objective To investigate the clinical characteristics and evaluate photodynamic therapy treatment combined with intravitreal injection of Lucentis for choroidal neovascularization secondary to angioid streaks. Methods This was an interventional retrospective analysis of 21 patients （42 eyes）. For clinical data， best corrected visual acuity （BCVA）， fundus appearance， fundus fluorescence angiography （FFA）， indocyanine green angiography （ICGA） and optical coherence tomography （OCT） were assessed. Twenty-two eyes of 18 patients with macular choroidal neovascularizaiton （CNV） were treated first with photodynamic therapy （PDT） and then with an intravitreal injection of Lucentis. The patients were followed up for at least 12 months. Another injection was given if one of the following appeared： decreased visual acuity， new macular lesions， subretinal or intraretinal fluid， or CNV leakage. Data were analyzed using an independent-samples t test or a paired-samples t test. Results Both eyes of all 21 patients were involved. Only 5 patients （24%） had complications with hologathy. Males were more affected （76%）. Of all the patients， 18 cases （86%） were diagnosed with CNV secondary to AS. BCVA was much worse in eyes with CNV. At the final follow-up after the combination treatment， BCVA had improved 10.4 characters. OCT showed macular retinal thickness decreased from 338.4±55.2 μm at baseline to 212.6±36.2 μm. FFA（ICGA） showed CNV leakage in 15 eyes （68%） had disappeared completely， and 5 eyes had scar staining. All patients received 1 treatment of PDT and a mean 3.2 intravitreal injections. Macular subretinal hemorrhage presented in 1 patient after PDT， but was absorbed completely after intravitreal injection. Five patients presented with transient elevated intraocular pressure and 4 patients had subconjunctival hemorrhage but all recovered quickly. No other ocular or adverse reactions occurred. Conclusion Angioid streaks present a special fundus appearance， and FFA（ICGA） is valuable in the diagnosis. A considerable propo

Key words： Angioid streaks Choroidal neovascularization Fluorescein angiography Photochemo therapy Vascular endothelial growth factor A

Received: 10 November 2014

Corresponding Authors: Song Yanping， Email： songyanping@medmail.com.cn

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	Chen Zhongshan
	Song Yanping
	Ding Qin
	Ye Ya
	Zeng Miao

Cite this article:

Chen Zhongshan,Song Yanping,Ding Qin等. Clinical characteristics and combined treatment for choroidal neovascularization secondary to angioid streaks[J]. Chinese Journal of Optometry Ophthalmology and Visual science, 2015, 17(3): 166-170.

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https://www.cjoovs.com/EN/10.3760/cma.j.issn.1674-845X.2015.03.009 OR https://www.cjoovs.com/EN/Y2015/V17/I3/166

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