Objective To evaluate the effect of strabismus surgery on the quality of life in strabismus patients. Methods From November 2013 to September 2014， 89 strabismus patients at West China Hospital were evaluated with an Adult Strabismus （AS-20） test and were followed up for （83.6±34.0）days. The difference between pre- and postoperative scores was analyzed using the AS-20 test and its subscales （psychosocial and functional）. The influence of age， gender， deviation type， and the existence or non-existence of binocular vision were compared using independent samples t test， rank sum test， Spearman test. Results The preoperative AS-20 total score was 50.3±18.5 and was significantly higher at 80.8±20.6 postoperatively （t=9.975， P<0.01）. Females had a lower preoperative AS-20 total score but had greater improvement compared to males （tpre=2.050， tchange=-2.593， P<0.05）. Patients with esotropia and exotropia （tpre=-0.480， tpost=0.237， tchange=1.495， P>0.05） and the existence of binocular vision （tpre=0.446， tpost=0.498， P>0.05） did not show a statistically significant difference in the AS-20 total scores or a change in AS-20 scores. There was no correlation between age and the change in AS-20 scores （r=0.021， P>0.05）. Conclusion Strabismus surgery resulted in a highly significant improvement in quality-of-life scores. Females had a lower quality-of-life preoperatively but had a greater benefit. There was no relationship between the deviation type， age， or the existence or non-existence of binocular vision and the AS-20 scores.