Objective To study the clinical efficacy of periocular massage and point application with Chinese medicine in treating juvenile myopia patients with nearwork-induced asthenopia． Methods A clinical randomized， controlled study was performed on 107 juvenile myopia patients with asthenopia from June to September 2011． Thirty-nine patients were treated with periocular massage and point application for 2 weeks in the treated 2W group； 38 patients received the same treatment for 4 weeks in the treated 4W group； 30 patients were treated with esculin and digitalisglycosides eye drops for 4 weeks in the contrast group. Scores for asthenopia symptoms， UCVA （uncorrected vision acuity） and accommodative function were measured at the following time points： before treatment and 2 weeks and 4 weeks after treatment． Results ①UCVA： after 4 weeks， UCVA had improved to a certain extent （F=39.66， P<0.01）， but there were no statistically significant differences among the groups． ②Score for asthenopia symptoms： the score decreased significantly （F=175.91， P<0.01）， but there were no significant differences among the groups． ③Accommodative function： after 4 weeks， all parameters for accommodative function， including amplitude of accommodation， accommodative facility， accommodative lag and negative relative accommodation/positive relative accommodation （NRA/PRA） had improved significantly in all three groups （F=24.80， 101.22， 11.73， 10.34， 31.68， P＜0.01）． Moreover， the treated 4W group produced the best results for accommodative facility （F=3.66， P<0.05） and accommodative lag （F=4.73， P<0.01） compared to the other groups． However， there were no significant differences in amplitude of accommodation or NRA/PRA among the groups． Conclusion Periocular massage and point application with Chinese medicine and escuilin and digitalisglycosides eye drops all improved UCVA， asthenopia symptoms and accommodative function. But periocular massage and point application with Chinese medicine is more conducive to improve the patient′s accommodative facility and accommodative lag． It may have a certain effectiveness for preventing myopia progression．