Objective  To study the long-term （five-year follow-up） changes in posterior corneal curvature and central corneal thickness by using the OrbscanⅡ topographer in patients who had undergone laser in situ keratomileusis （LASIK） for myopia. Methods  Forty-eight eyes of 48 patients who had undergone LASIK for myopia were included in a retrospective observational case series study. The mean preoperative refractive error was -6.25±2.87 D. The preoperative and postoperative changes in the posterior corneal curvature and central corneal thickness of each eye were measured by OrbscanⅡ. The posterior corneal curvature was obtained from the central 6mm zone of the OrbscanⅡ. The postoperative follow-up period was at 1， 3， 6， 9， 12， 24， 36 and 60 months. Using SPSS 16.0 software， a comparison of the least-significant difference （LSD） pairwise was used to analyze the difference in the posterior corneal curvature and central corneal thickness at each follow-up visit. Results  ①The posterior corneal curvature was higher in the 1st month postoperatively compared to preoperative curvature （t=8.211， P<0.01）. There was no statistically significant difference for the change in posterior corneal curvature from the 1st month to the 9th month （P>0.05）. The posterior corneal curvature slowly decreased over time from the 9th month to the 24th month （the values of t were -4.640 and -2.659， the values of P were <0.001 and 0.014）. The posterior corneal curvature did not become stable until after the 24th month （P>0.05）. ②The central corneal thickness was lower in the 1st month postoperatively than preoperative thickness （t=10.08， P<0.01）. The central corneal thickness slowly increased over time from the 1st month to the 9th month （the values of t were -5.402， -4.428 and -2.334， the values of P were <0.001， <0.001 and 0.027）. The central corneal thickness did not become stable until after the 9th month （P>0.05）.③The posterior corneal curvature was correlated with corneal thickness （r=-0.703， P<0.01）. Conclusion  The posterior corneal curvature and the central corneal thickness both increase shortly after LASIK surgery and stabilize after this initial period. There is a negative correlation between posterior corneal curvature and central corneal thickness.