Abstract：Objective: To assess the effect of oral vitamin D3 supplementation for dry eye after femtosecond laserassisted LASIK (FS-LASIK). Methods: In this prospective study, 90 patients who underwent FSLASIK surgery in Liuzhou Workers' Hospital from January to December 2019 and who had obvious dry eyes one month after the operation were selected. The subjects were randomly divided into two groups: An experimental group (n=45) that received vitamin D3 2 000 IU/d continuously for 12 weeks after the operation and a control group (n=45) that did not take vitamin D3 orally. The ocular surface disease index (OSDI), tear break up time (TBUT) and Shirmer Ⅰ test were used to evaluate patients preoperatively and 1, 3 and 6 months after treatment. Serum vitamin D level was also measured. Kolmogorov-Smirnov, LSD-t test and independent sample t test were used for statistics analysis. Results: One month after treatment, the mean OSDI score of the experimental group was significantly lower than that of the control group (t=4.32, P=0.007). TBUT and Schirmer Ⅰ of the experimental group were higher than those of the control group. The OSDI (t=2.50, P=0.010), TBUT (t=2.32, P=0.031) and Schirmer Ⅰ test values (t=3.25, P=0.026) of the experimental group were significantly lower than those of the control group at 3 months after treatment. There were significant differences in OSDI (t=2.31, P=0.025), TBUT (t=2.30, P=0.039) and Schirmer Ⅰ test values (t=3.03, P=0.028) between the two groups at 6 months after treatment. Serum vitamin D3 level was negatively correlated with the OSDI score (r=-0.90, P<0.001), and positively correlated with the Schirmer Ⅰ test (r=0.88, P<0.001), TBUT score (r=0.89, P<0.001) and TMH (r=0.80, P<0.001). Conclusions: Vitamin D3 has positive effects on post-LASIK dry eye symptoms, tear quality and the ocular surface condition. Vitamin D3 also improved visual quality after FS-LASIK.
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