Objective Observation of the clinical outcomes of transepithelial phototherapeutic keratectomy (TPTK) for treatment of recurrent corneal erosion and discussion of the surgery design elements, safety, and effectiveness. Methods This retrospective study included 8 patients (4 males, 4 females, average age 36.6±10.0 years) who suffered recurrent corneal erosions and had TPTK surgeries in one eye by excimer laser at Chongqing Aier Eye Hospital from December 2014 to September 2015. Corneal healing speed, corneal erosion recrudescence, and complications (especially haze) were recorded. Uncorrected visual acuities (UCVAs), intraocular pressures, planned cut depths, central cut depths, and maximum cut depths for the intermittent periods without disease, exacerbation times (before surgery), and 6 months after surgery were compared by paired t-tests. Results None of the 8 patients suffered recurrent corneal erosion during the follow-up period (6-16 months). There were significant differences in the UCVAs for the intermittent periods, exacerbation periods, and at the 6-months follow-up time after surgery (F=5.165, P=0.015), but there was no difference in the UCVAs between the intermittent period and 6 months after surgery. Moreover, there was no post-operative haze, and all eye irritation symptoms improved or disappeared after 4 d. There was no significant difference in the depth of the planned cut depth and the central depth of the actual cut area (t=0, P=1.000), but actual cut central depth was significantly less than the actual maximum peripheral depth (t=-18.63, P<0.001). Conclusion TPTK of recurrent corneal erosion is safe and effective and thus should be considered as an appropriate method to treat this condition.