Research Progress on MMPs/TIMPs and the Mechanism of Myopia Formation and Development
Tianrui He1,2, Jibo Zhou1,2
1Department of Ophthalmology, Ninth People's Hospital, Shanghai JiaoTong University School of
Medicine, Shanghai 200011, China
2Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology, Shanghai 200011, China
The incidence of myopia has increased in recent years. Studies of myopic animal models and clinical trials have demonstrated that matrix metalloproteinases (MMPs) and tissue inhibitors of matrix metalloproteinases (TIMPs) play important roles in the development of myopia. We summarizes the association between MMPs/TIMPs and myopia development. It also clarifies the effect of MMPs/TIMPs on scleral and other ocular tissues from the perspective of gene expression, mRNA levels, and protein concentrations.
何恬睿,周激波. MMPs/TIMPs在近视发生发展中的机制研究进展[J]. 中华眼视光学与视觉科学杂志, 2018, 20(1): 61-64.
Tianrui He1,2, Jibo Zhou1,2. Research Progress on MMPs/TIMPs and the Mechanism of Myopia Formation and Development. Chinese Journal of Optometry Ophthalmology and Visual science, 2018, 20(1): 61-64. DOI: 10.3760/cma.j.issn.1674-845X.2018.01.012
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