Efficacy and Safety of Orthokeratology for Slowing Myopia Progression in Children: A Meta-Analysis Study
Xin Ai1, Xuehui Zhang1, Lu Ye2
1Department of Ophthalmology, Xi'an First Hospital, Institute of Ophthalmology, Key Lab of Ophthalmology, Clinical Center for Ophthalmology, Xi'an 710002, China; 2Department of Ophthalmology, the Fourth Hospital of Xi'an, Xi'an 710004, China
Abstract：Objective: To evaluate the efficacy and safety of orthokeratology for slowing myopia progression in children using meta-analysis. Methods: This study was evidence-based research. Studies about the efficacy and safety of orthokeratology, which have involved children, were obtained from Medline, CNKI, and Wan Fang before January 2017. Selected studies were processed in meta-analysis by using the Stata version 11.0. The pooled weighted mean difference (WMD), odds ratio (OR) and 95% confidence interval (CI) of the axial length change and adverse reaction rates during 1-year and 2-year follow-ups were calculated. Subgroup analysis was conducted based on study type, race, and measurement instruments. Results: Fourteen studies involving 2 563 subjects were included. There were 1 339 subjects in the orthokeratology group (experimental) and 1 224 subjects in the spectacle group (control). The results showed that during the 2-year follow-up, a statistically significant difference was observed in axial length change between the orthokeratology and control groups, with a WMD of -0.361 mm (95%CI: -0.604 to 0.118). During the 1-year follow-up, a statistically significant difference was observed in axial length change between the orthokeratology and control groups, with a WMD of -0.356 (95%CI: -0.610 to -0.102). The myopia control rate was 66.6% and 51.3% in the 1-year and 2-year follow-ups, respectively (myopia control rate=change in axial length in the experimental group-change in axial length in the control group/change in axial length in the control group). The OR of the adverse rate between the orthokeratology and control groups in 2 years was 6.408 (95%CI: 2.460 to 16.688). Conclusions: Orthokeratology is effective and safe for slowing myopia progression in children.
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Xin Ai, Xuehui Zhang, Lu Ye. Efficacy and Safety of Orthokeratology for Slowing Myopia Progression in Children: A Meta-Analysis Study. Chinese Journal of Optometry Ophthalmology and Visual science, 2019, 21(2): 127-134. DOI: 10.3760/cma.j.issn.1674-845X.2019.02.009
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