Objective: To develop a Chinese version of the Contact Lens Impact on Quality of Life questionnaire (CLIQ), assess its reliability and validity, and analyze the factors that influence the score. Methods: A Chinese version of CLIQ was developed, including forward and backward translation and a cultural adaptation of the original English CLIQ. Then a cross-sectional investigation was carried out. Two hundred and five patients were selected from the Eye Hospital, Wenzhou Medical Universtity and than evaluated using the Chinese version of CLIQ, 20 of them were randomly selected and evaluated by two investigators separately. Questionnaire data were statistically analyzed. Results: A total 201 questionnaires were analyzed. The visual function domain was discarded because of the low response rate (less than 50%). Cronbach's α coefficient scale was 0.77, the ocular symptoms domain was 0.68, and the convenience, economy and well-being domains were more than 0.7. The Guttmann Split-half reliability scale was 0.89, and 0.75, 0.78, 0.65 and 0.93 for the convenience, economy and well-being domains, respectively. Cronbach's α coefficient and Guttmann Split-half coefficient were both 0.49 for the cognitive domain. Cronbach's α coefficient and Guttmann Split-half coefficient increased to 0.68 and 0.73, respectively, after deleting item 20 in the well-being domain, so items 15, 16 and 20 were deleted. Scores between the two investigators had a high positive correlation (r=0.87-0.99, P<0.001). The item level content validity index of each item was 0.83-1.00; the average level of the content validity index of the scale was 0.95. Five extracted factors corresponded to each domainby exploratory factor analysis and the cumulative variance contribution rate was 60.43%. The ocular symptoms domain had as light negative correlation with age (r=- 0.153, P=0.03) and the number of years the lenses were worn (r=-0.167, P=0.018); the well-being domain was slightly correlated with the number of years the lenses were worn (r=0.209, P=0.003). The total score of the scale was significantly different between the number of years the lenses were worn (3.60±0.34 vs. 3.71±0.32, P=0.026), the days the lenses were wornper month (3.60±0.33 vs. 3.70±0.33, P=0.041) and those with/without ocular symptoms (3.71±0.32 vs. 3.60±0.34, P=0.021). The score of economic domain of soft contact lens wearers were higher than that of RGP wearers (t=2.588, P=0.017). Conclusions: After removing the visual function domain, cognitive domain and item 20, the CLIQ's reliability and validity are good. Those who wore the lenses for more years, more days per month and without ocular symptoms score higher. Rigid gas permeable contact lens (RGP) wearers are more worried about cost.