Molecularly imprinted contact lenses (MI-CL) can provide sustained drug release and improve the efficiency of ophthalmic drug delivery. They can significantly decrease the patients' discomfort caused by eye drops, but can also reload relevant drugs. More importantly, they can load high-molecular drugs. They show great potential application in the ophthalmology clinic. In this review, the principle and development,and the drug-loading model and sustained-release model of the MI-CL are included and discussed. This review can be useful for the design of novel contact lenses for clinical applications and the improvement of drug-loaded contact lenses in the future.
Hu X, Tan H, Chen P, et al. Polymer micelles laden hydrogel contact lenses for ophthalmic drug delivery. J Nanosci Nanotechnol, 2016, 16(6): 5480-5488.DOI: 10.1166/jnn.2016.
11
733.
[2]
Hu X, Hao L, Wang H, et al. Hydrogel contact lens for extended delivery of ophthalmic drugs. Int J Polym Sci, 2011, 2011(1687-9422): 2341-2348. DOI: 10.1155/2011/814163.
[3]
Carvalho IM, Marques CS, Oliveira RS, et al. Sustained drug release by contact lenses for glaucoma treatment-a review. J Control Release, 2015, 202: 76-82. DOI: 10.1016/j.jconrel.
11
733.
[2]
Hu X, Hao L, Wang H, et al. Hydrogel contact lens for extended delivery of ophthalmic drugs. Int J Polym Sci, 2011, 2011(1687-9422): 2341-2348. DOI: 10.1155/2011/814163.
[3]
Carvalho IM, Marques CS, Oliveira RS, et al. Sustained drug release by contact lenses for glaucoma treatment-a review. J Control Release, 2015, 202: 76-82. DOI: 10.1016/j.jconrel.
White CJ, McBride MK, Pate KM, et al. Extended release of high molecular weight hydroxypropyl methylcellulose from molecularly imprinted, extended wear silicone hydrogel contact
González-Chomón C, Silva M, Concheiro A, et al. Biomimetic contact lenses eluting olopatadine for allergic conjunctivitis.Acta Biomater, 2016, 41: 302-311. DOI: 10.1016/j.actbio.2016.05.032.
[5]
White CJ, McBride MK, Pate KM, et al. Extended release of high molecular weight hydroxypropyl methylcellulose from molecularly imprinted, extended wear silicone hydrogel contact
González-Chomón C, Silva M, Concheiro A, et al. Biomimetic contact lenses eluting olopatadine for allergic conjunctivitis.Acta Biomater, 2016, 41: 302-311. DOI: 10.1016/j.actbio.2016.05.032.
[7]
Maulvi FA, Shaikh AA, Lakdawala DH, et al. Design and optimization of a novel implantation technology in contact lenses for the treatment of dry eye syndrome: In-vitro and in-
vivo evaluation. Acta Biomater, 2017, 53: 211-221. DOI:10.1016/j.actbio.2017.01.063.
[8]
White CJ, Tieppo A, Byrne ME. Controlled drug release from contact lenses: a comprehensive review from 1965-present. J Drug Deliv Sci Tec, 2011, 21(5): 369-384. DOI: 10.1016/S1773-2247(11)50062-0.
[9]
Alvarez-Lorenzo C, Yañez F, Concheiro A. Ocular drug delivery from molecularly-imprinted contact lenses. J Drug Deliv Sci Tec, 2010, 20(4): 237-248. DOI: 10.1016/S1773-
[7]
Maulvi FA, Shaikh AA, Lakdawala DH, et al. Design and optimization of a novel implantation technology in contact lenses for the treatment of dry eye syndrome: In-vitro and in-
vivo evaluation. Acta Biomater, 2017, 53: 211-221. DOI:10.1016/j.actbio.2017.01.063.
[8]
White CJ, Tieppo A, Byrne ME. Controlled drug release from contact lenses: a comprehensive review from 1965-present. J Drug Deliv Sci Tec, 2011, 21(5): 369-384. DOI: 10.1016/S1773-2247(11)50062-0.
[9]
Alvarez-Lorenzo C, Yañez F, Concheiro A. Ocular drug delivery from molecularly-imprinted contact lenses. J Drug Deliv Sci Tec, 2010, 20(4): 237-248. DOI: 10.1016/S1773-
22
47(10)50041-8.
[10]
Hsu KH, Gause S, Chauhan A. Review of ophthalmic drug delivery by contact lenses. J Drug Deliv Sci Tec, 2014, 24(2):123-135. DOI: 10.1016/S1773-2247(14)50021-4.
[11]
Maulvi FA, Soni TG, Shah DO. A review on therapeutic contact lenses for ocular drug delivery. Drug Deliv, 2016, 23(8): 3017-3026. DOI: 10.3109/10717544.2016.1138342.
[12]
Luliński P. Molecularly imprinted polymers based drug delivery devices: a way to application in modern pharmacotherapy. A review. Mater Sci Eng C Mater Biol Appl, 2017, 76: 1344-1353.DOI: 10.1016/j.msec.2017.02.138.
[13]
El-Kosasy AM, Kamel AH, Hussin LA, et al. Mimicking new receptors based on molecular imprinting and their application to potentiometric assessment of 2, 4-dichlorophenol as a food taint.Food Chem, 2018, 250: 188-196. DOI: 10.1016/j.foodchem.2018.01.014.
[14]
Afsarimanesh N, Mukhopadhyay SC, Kruger M. Molecularly imprinted polymer-based electrochemical biosensor for bone loss detection. IEEE Trans Biomed Eng, 2018, 65(6): 1264-1271. DOI: 10.1109/TBME.2017.2744667.
[15]
Bhawani SA, Sen TS, Ibrhim MNM. Synthesis of molecular imprinting polymers for extraction of gallic acid from urine.Chem Cent J, 2018, 12(1): 19. DOI: 10.1186/s13065-018-0392-7.
[16]
Zaidi SA. Molecular imprinted polymers as drug delivery vehicles. Drug Deliv, 2016, 23(7): 2262-2271. DOI: 10.3109/10717544.2014.970297.
[17]
Chen S, Dong L, Yan M, et al. Rapid and sensitive biomarker detection using molecular imprinting polymer hydrogel and surface-enhanced Raman scattering. R Soc Open Sci, 2018,5(1): 171488-171496. DOI: 10.1098/rsos.171488.
[18]
Gagliardi M, Bertero A, Bifone A. Molecularly imprinted biodegradable nanoparticles. Sci Rep, 2017, 7: 40046. DOI:10.1038/srep40046.
[19]
Neves MI, Wechsler ME, Gomes ME, et al. Molecularly imprinted intelligent scaffolds for tissue engineering applications. Tissue Eng Part B Rev, 2017, 23(1): 27-43. DOI:
22
47(10)50041-8.
[10]
Hsu KH, Gause S, Chauhan A. Review of ophthalmic drug delivery by contact lenses. J Drug Deliv Sci Tec, 2014, 24(2):123-135. DOI: 10.1016/S1773-2247(14)50021-4.
[11]
Maulvi FA, Soni TG, Shah DO. A review on therapeutic contact lenses for ocular drug delivery. Drug Deliv, 2016, 23(8): 3017-3026. DOI: 10.3109/10717544.2016.1138342.
[12]
Luliński P. Molecularly imprinted polymers based drug delivery devices: a way to application in modern pharmacotherapy. A review. Mater Sci Eng C Mater Biol Appl, 2017, 76: 1344-1353.DOI: 10.1016/j.msec.2017.02.138.
[13]
El-Kosasy AM, Kamel AH, Hussin LA, et al. Mimicking new receptors based on molecular imprinting and their application to potentiometric assessment of 2, 4-dichlorophenol as a food taint.Food Chem, 2018, 250: 188-196. DOI: 10.1016/j.foodchem.2018.01.014.
[14]
Afsarimanesh N, Mukhopadhyay SC, Kruger M. Molecularly imprinted polymer-based electrochemical biosensor for bone loss detection. IEEE Trans Biomed Eng, 2018, 65(6): 1264-1271. DOI: 10.1109/TBME.2017.2744667.
[15]
Bhawani SA, Sen TS, Ibrhim MNM. Synthesis of molecular imprinting polymers for extraction of gallic acid from urine.Chem Cent J, 2018, 12(1): 19. DOI: 10.1186/s13065-018-0392-7.
[16]
Zaidi SA. Molecular imprinted polymers as drug delivery vehicles. Drug Deliv, 2016, 23(7): 2262-2271. DOI: 10.3109/10717544.2014.970297.
[17]
Chen S, Dong L, Yan M, et al. Rapid and sensitive biomarker detection using molecular imprinting polymer hydrogel and surface-enhanced Raman scattering. R Soc Open Sci, 2018,5(1): 171488-171496. DOI: 10.1098/rsos.171488.
[18]
Gagliardi M, Bertero A, Bifone A. Molecularly imprinted biodegradable nanoparticles. Sci Rep, 2017, 7: 40046. DOI:10.1038/srep40046.
[19]
Neves MI, Wechsler ME, Gomes ME, et al. Molecularly imprinted intelligent scaffolds for tissue engineering applications. Tissue Eng Part B Rev, 2017, 23(1): 27-43. DOI:
10
1089/ten.TEB.2016.0202.
[20]
Hiratani H, Alvarez-Lorenzo C. Timolol uptake and release by imprinted soft contact lenses made of N, N -diethylacrylamide and methacrylic acid. J Control Release, 2002, 83(2): 223-230.DOI: 10.1016/S0168-3659(02)00213-4.
10
1089/ten.TEB.2016.0202.
[20]
Hiratani H, Alvarez-Lorenzo C. Timolol uptake and release by imprinted soft contact lenses made of N, N -diethylacrylamide and methacrylic acid. J Control Release, 2002, 83(2): 223-230.DOI: 10.1016/S0168-3659(02)00213-4.
[21]
Guidi G, Korogiannaki M, Sheardown H. Modification of timolol release from silicone hydrogel model contact lens materials using hyaluronic acid. Eye Contact Lens, 2014, 40(5):
26
9-276. DOI: 10.1097/ICL.0000000000000033.
[22]
Tashakorisabzevar F, Mohajeri SA. Development of ocular drug delivery systems using molecularly imprinted soft contact lenses. Drug Dev Ind Pharm, 2015, 41(5): 703-713. DOI:
[21]
Guidi G, Korogiannaki M, Sheardown H. Modification of timolol release from silicone hydrogel model contact lens materials using hyaluronic acid. Eye Contact Lens, 2014, 40(5):
26
9-276. DOI: 10.1097/ICL.0000000000000033.
[22]
Tashakorisabzevar F, Mohajeri SA. Development of ocular drug delivery systems using molecularly imprinted soft contact lenses. Drug Dev Ind Pharm, 2015, 41(5): 703-713. DOI:
10
3109/03639045.2014.948451.
[23]
Malakooti N, Alexander C, Alvarez-Lorenzo C. Imprinted contact lenses for sustained release of polymyxin B and related antimicrobial peptides. J Pharm Sci, 2015, 104(10): 3386-3394.DOI: 10.1002/jps.24537.
[24]
Alvarez-Rivera F, Concheiro A, Alvarez-Lorenzo C. Epalrestat- loaded silicone hydrogels as contact lenses to address diabetic- eye complications. Eur J Pharm Biopharm, 2018, 122: 126-136.DOI: 10.1016/j.ejpb.2017.10.016.
[25]
Braga MEM, Yañez F, Alvarez-Lorenzo C, et al. Improved drug loading/release capacities of commercial contact lenses obtained by supercritical fluid assisted molecular imprinting methods.J Control Release, 2010, 148(1): e102-e104. DOI:10.1016/j.jconrel.2010.07.077.
10
3109/03639045.2014.948451.
[23]
Malakooti N, Alexander C, Alvarez-Lorenzo C. Imprinted contact lenses for sustained release of polymyxin B and related antimicrobial peptides. J Pharm Sci, 2015, 104(10): 3386-3394.DOI: 10.1002/jps.24537.
[24]
Alvarez-Rivera F, Concheiro A, Alvarez-Lorenzo C. Epalrestat- loaded silicone hydrogels as contact lenses to address diabetic- eye complications. Eur J Pharm Biopharm, 2018, 122: 126-136.DOI: 10.1016/j.ejpb.2017.10.016.
[25]
Braga MEM, Yañez F, Alvarez-Lorenzo C, et al. Improved drug loading/release capacities of commercial contact lenses obtained by supercritical fluid assisted molecular imprinting methods.J Control Release, 2010, 148(1): e102-e104. DOI:10.1016/j.jconrel.2010.07.077.
[26]
Malaekeh-Nikouei B, Vahabzadeh SA, Mohajeri SA. Preparation of a molecularly imprinted soft contact lens as a new ocular drug delivery system for dorzolamide. Curr Drug Deliv, 2013, 10(3):279-285.
Anirudhan TS, Nair AS, Parvathy J. Extended wear therapeutic contact lens fabricated from timolol imprinted carboxymethyl chitosan-g-hydroxy ethyl methacrylate-g-poly acrylamide as a one time medication for glaucoma. Eur J Pharm Biopharm,2016, 109: 61-71. DOI: 10.1016/j.ejpb.2016.09.010.
[29]
Yañez F, Chauhan A, Concheiro A, et al. Timolol-imprinted soft contact lenses: Influence of the template: Functional monomer ratio and the hydrogel thickness. J Appl Polym Sci, 2011,122(2): 1333-1340. DOI: 10.1002/app.34022.
[30]
Hiratani H, Fujiwara A, Tamiya Y, et al. Ocular release of timolol from molecularly imprinted soft contact lenses.Biomaterials, 2005, 26(11): 1293-1298. DOI: 10.1016/
[26]
Malaekeh-Nikouei B, Vahabzadeh SA, Mohajeri SA. Preparation of a molecularly imprinted soft contact lens as a new ocular drug delivery system for dorzolamide. Curr Drug Deliv, 2013, 10(3):279-285.
Anirudhan TS, Nair AS, Parvathy J. Extended wear therapeutic contact lens fabricated from timolol imprinted carboxymethyl chitosan-g-hydroxy ethyl methacrylate-g-poly acrylamide as a one time medication for glaucoma. Eur J Pharm Biopharm,2016, 109: 61-71. DOI: 10.1016/j.ejpb.2016.09.010.
[29]
Yañez F, Chauhan A, Concheiro A, et al. Timolol-imprinted soft contact lenses: Influence of the template: Functional monomer ratio and the hydrogel thickness. J Appl Polym Sci, 2011,122(2): 1333-1340. DOI: 10.1002/app.34022.
[30]
Hiratani H, Fujiwara A, Tamiya Y, et al. Ocular release of timolol from molecularly imprinted soft contact lenses.Biomaterials, 2005, 26(11): 1293-1298. DOI: 10.1016/
j.biomaterials.2004.04.030.
[31]
Ribeiro AM, Figueiras A, Veiga F. Improvements in topical ocular drug delivery systems: hydrogels and contact lenses.J Pharm Pharm Sci, 2015, 18(5): 683-695. DOI: 10.18433/
j.biomaterials.2004.04.030.
[31]
Ribeiro AM, Figueiras A, Veiga F. Improvements in topical ocular drug delivery systems: hydrogels and contact lenses.J Pharm Pharm Sci, 2015, 18(5): 683-695. DOI: 10.18433/
J3H60P.
J3H60P.
[32]
Yokozaki Y, Sakabe J, Ng B, et al. Effect of temperature, pressure and depressurization rate on release profile of salicylic acid from contact lenses prepared by supercritical carbon
dioxide impregnation. Che Eng Res Des, 2015, 100(1): 89-94.DOI: 10.1016/j.cherd.2015.05.008.
[33]
Yañez F, Martikainen L, Braga ME, et al. Supercritical fluid- assisted preparation of imprinted contact lenses for drug delivery. Acta Biomater, 2011, 7(3): 1019-1030. DOI: 10.1016/
[32]
Yokozaki Y, Sakabe J, Ng B, et al. Effect of temperature, pressure and depressurization rate on release profile of salicylic acid from contact lenses prepared by supercritical carbon
dioxide impregnation. Che Eng Res Des, 2015, 100(1): 89-94.DOI: 10.1016/j.cherd.2015.05.008.
[33]
Yañez F, Martikainen L, Braga ME, et al. Supercritical fluid- assisted preparation of imprinted contact lenses for drug delivery. Acta Biomater, 2011, 7(3): 1019-1030. DOI: 10.1016/
j.actbio.2010.10.003.
[34]
Mahomed A, Wolffsohn JS, Tighe BJ. Structural design of contact lens-based drug delivery systems; in vitro and in vivo studies of ocular triggering mechanisms. Cont Lens Anterior Eye, 2016, 39(2): 97-105. DOI: 10.1016/j.clae.2015.07.007.
[35]
Ali M, Horikawa S, Venkatesh S, et al. Zero-order therapeutic release from imprinted hydrogel contact lenses within in vitro physiological ocular tear flow. J Control Release, 2007, 124(3):154-162. DOI: 10.1016/j.jconrel.2007.09.006.
[36]
Ali M, Byrne ME. Controlled release of high molecular weight hyaluronic acid from molecularly imprinted hydrogel contact lenses. Pharm Res, 2009, 26(3): 714-726. DOI: 10.1007/s11095-008-9818-6.
[37]
Ribeiro A, Veiga F, Santos D, et al. Bioinspired imprinted PHEMA-hydrogels for ocular delivery of carbonic anhydrase inhibitor drugs. Biomacromolecules, 2011, 12(3): 701-709. DOI:10.1021/bm101562v.
[38]
Maulvi FA, Choksi HH, Desai AR, et al. pH triggered controlled drug delivery from contact lenses: Addressing the challenges of drug leaching during sterilization and storage. Colloids Surf B Biointerfaces, 2017, 157: 72-82. DOI: 10.1016/j.colsurfb.2017.05.064.
[39]
Qin G, Zhu Z, Li S, et al. Development of ciprofloxacin-loaded contact lenses using fluorous chemistry. Biomaterials, 2017,124: 55-64. DOI: 10.1016/j.biomaterials.2017.01.046.
[40]
Hui A, Willcox M, Jones L. In vitro and in vivo evaluation of novel ciprofloxacin-releasing silicone hydrogel contact lenses.nvest Ophthalmol Vis Sci, 2014, 55(8): 4896-4904. DOI:10.1167/iovs.14-14855.
j.actbio.2010.10.003.
[34]
Mahomed A, Wolffsohn JS, Tighe BJ. Structural design of contact lens-based drug delivery systems; in vitro and in vivo studies of ocular triggering mechanisms. Cont Lens Anterior Eye, 2016, 39(2): 97-105. DOI: 10.1016/j.clae.2015.07.007.
[35]
Ali M, Horikawa S, Venkatesh S, et al. Zero-order therapeutic release from imprinted hydrogel contact lenses within in vitro physiological ocular tear flow. J Control Release, 2007, 124(3):154-162. DOI: 10.1016/j.jconrel.2007.09.006.
[36]
Ali M, Byrne ME. Controlled release of high molecular weight hyaluronic acid from molecularly imprinted hydrogel contact lenses. Pharm Res, 2009, 26(3): 714-726. DOI: 10.1007/s11095-008-9818-6.
[37]
Ribeiro A, Veiga F, Santos D, et al. Bioinspired imprinted PHEMA-hydrogels for ocular delivery of carbonic anhydrase inhibitor drugs. Biomacromolecules, 2011, 12(3): 701-709. DOI:10.1021/bm101562v.
[38]
Maulvi FA, Choksi HH, Desai AR, et al. pH triggered controlled drug delivery from contact lenses: Addressing the challenges of drug leaching during sterilization and storage. Colloids Surf B Biointerfaces, 2017, 157: 72-82. DOI: 10.1016/j.colsurfb.2017.05.064.
[39]
Qin G, Zhu Z, Li S, et al. Development of ciprofloxacin-loaded contact lenses using fluorous chemistry. Biomaterials, 2017,124: 55-64. DOI: 10.1016/j.biomaterials.2017.01.046.
[40]
Hui A, Willcox M, Jones L. In vitro and in vivo evaluation of novel ciprofloxacin-releasing silicone hydrogel contact lenses.nvest Ophthalmol Vis Sci, 2014, 55(8): 4896-4904. DOI:10.1167/iovs.14-14855.
[41]
Mehta P, Haj-Ahmad R, Al-Kinani A, et al. Approaches in topical ocular drug delivery and developments in the use of contact lenses as drug-delivery devices. Ther Deliv, 2017, 8(7):
52
1-541. DOI: 10.4155/tde-2017-0018.
[42]
Dhanashree S, Priyanka M, Manisha K, et al. Molecularly imprinted polymers: novel discovery for drug delivery. Curr Drug Deliv, 2016, 13(5): 632-645. DOI: 10.2174/156720181366
[41]
Mehta P, Haj-Ahmad R, Al-Kinani A, et al. Approaches in topical ocular drug delivery and developments in the use of contact lenses as drug-delivery devices. Ther Deliv, 2017, 8(7):
52
1-541. DOI: 10.4155/tde-2017-0018.
[42]
Dhanashree S, Priyanka M, Manisha K, et al. Molecularly imprinted polymers: novel discovery for drug delivery. Curr Drug Deliv, 2016, 13(5): 632-645. DOI: 10.2174/156720181366
61
60101120238.
[43]
White CJ, Dipasquale SA, Byrne ME. Controlled release of multiple therapeutics from silicone hydrogel contact lenses. Optom Vis Sci, 2016, 93(4): 377-386. DOI: 10.1097/
61
60101120238.
[43]
White CJ, Dipasquale SA, Byrne ME. Controlled release of multiple therapeutics from silicone hydrogel contact lenses. Optom Vis Sci, 2016, 93(4): 377-386. DOI: 10.1097/
OPX.0000000000000849.
[44]
Naroo SA. Future of contact lens usage. Cont Lens Anterior Eye, 2013, 36(4): 155. DOI: 10.1016/j.clae.2013.05.001.
OPX.0000000000000849.
[44]
Naroo SA. Future of contact lens usage. Cont Lens Anterior Eye, 2013, 36(4): 155. DOI: 10.1016/j.clae.2013.05.001.