Abstract：Objective: To evaluate the safety, efficacy and visual outcomes in myopic and presbyopic patients, after Q-value-guided non-linear aspherical monocular LASIK. Methods: A prospective study was performed based on 50 patients (100 eyes) who underwent Q-value-guided non-linear aspherical LASIK. They were recruited in Liuzhou Worker's Hospital from January to December 2018. One week, 1 month, 3 months and 6 months after the operation, the patients' postoperative follow-up included assessments of visual acuity, auto-refraction, Q-value, spherical aberration, contrast sensitivity, corneal topography, stereoacuity and so on. The impact of the operation at 6 months was evaluated with the Chinese quality-of-life impact of refractive correction scale (QIRC). A t-test and repeated measurement analysis of variance were used for data analysis. Results: The demographic information was matched preoperatively between the two eyes. Six months postoperatively, 47 patients achieved an uncorrected distance visual acuity of 0.0 or better in the dominant eye, an uncorrected near visual acuity of 0.3 or better in 48 patients (96%), and 0.33 in the non-dominant eye of all patients. At 6 months, there was a significant difference in Q-value between the dominant eye and the non-dominant eye (t=2.142, P=0.03). Refractive error and Q-value were positively correlated with spherical aberration (r=0.496, P<0.001; r=0.197, P=0.05). At one week postoperatively, all contrast sensitivity spatial frequencies were lower than that before surgery, and gradually reached the preoperative level at 6 months postoperatively (all P<0.05). Most of the patients reported good visual quality, but 2 of them complained of night glare and ghosting. There was no significant difference in stereopsis 6 months postoperatively. Conclusions: Q-value-guided non-linear aspherical monocular LASIK is safe and effective to treat myopia and presbyopia.
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