外泌体在眼科疾病中的研究进展

doi:10.3760/cma.j.cn115909-20190314-00076

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摘要外泌体是由多种活细胞分泌的囊泡小体，普遍存在于血、尿液、唾液、腹水、羊水等体液中，参与细胞间交流、信号转导、遗传物质运输和免疫反应，具有广泛而重要的生物功能。在肿瘤、泌尿及循环系统的相关研究中，外泌体可作为生物标志物协助疾病的诊断与治疗，是当下的热点。近年来，外泌体在眼科的相关研究也逐步开展。现将就外泌体的基本生物学概况和在眼科中的相关研究进行综述。

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关键词 ：外泌体, 眼科疾病, 生物标志物, 诊断, 治疗

Abstract：Exosomes are small vesicular bodies secreted by various types of living cells, which extensively exist in all kinds of body fluids such as blood, urine, saliva, or amniotic fluid. Exosomes participate in numerous biological processes, including cell-cell communication, signal transduction, genetical material transportation and modulation of immune response. Researches in eye have also been gradually carried out in recent years. This review summaries the basic characteristics, biological functions and conclusions in studies of ocular diseases.

Key words： exosome ocular diseases biomarker diagnosis treatment

收稿日期: 2019-03-14

通讯作者: 赵培泉（ORCID：0000-0002-5092-9550），Email：zhaopeiquan@xinhuamed.com.cn

引用本文:

叶鸿飞费萍赵培泉. 外泌体在眼科疾病中的研究进展[J]. 中华眼视光学与视觉科学杂志, 2020, 22(6): 471-475. Hongfei Ye, Ping Fei, Peiquan Zhao. The Research Progress of Exosomes in Ocular Diseases. Chinese Journal of Optometry Ophthalmology and Visual science, 2020, 22(6): 471-475. DOI: 10.3760/cma.j.cn115909-20190314-00076

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https://www.cjoovs.com/CN/10.3760/cma.j.cn115909-20190314-00076 或 https://www.cjoovs.com/CN/Y2020/V22/I6/471

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