Abstract: Objective: To investigate the clinical characteristics, ocular biometric parameters and refraction of congenital fibrovascular pupillary membrane (CFPM) patients. Methods: This retrospective study included 15 eyes of 13 CFPM patients (11 unilateral cases, 2 bilateral cases) who underwent surgical treatment from July 2016 to December 2019 at the Eye Hospital, Wenzhou Medical University (Hangzhou). Age at surgery, concurrent eye anomalies, ocular biometric parameters, surgical approaches and refraction 1 week after surgery were recorded. Ten unilateral CFPM patients (1 patient excluded for secondary glaucoma) were divided into the CFPM group and the contralateral control group. Axial length (AL), corneal power and postoperative refraction were compared between the two groups. A paired t test was used to compare the differences in biological parameters between the CFPM group and the contralateral healthy eye group. Results: The concurrent eye anomalies of 13 CFPM patients included congenital cataract, persistent pupillary membrane (PPM), strabismus and secondary glaucoma (the data of one eye of a bilateral case excluded for did not undergo surgery). The AL of the CFPM group (19.87±2.01 mm) was shorter than that of the control group (20.38±1.76 mm), and the postoperative spherical equivalent (3.41±2.29 D) was higher than that of the control group (2.24±1.49 D), but the differences were not statistically significant. Corneal power was close between the two groups (mean corneal power 42.31±2.75 D vs. 42.40±1.05 D, t=-0.096, P=0.926). Conclusions: CFPM maybe accompanied by other concurrent eye anomalies. Compared to the contralateral healthy eye, CFPM eyes present a shorter axial length and higher hyperopia. Clinicians should pay attention to the ocular biometric parameters of CFPM patients preoperatively and refraction postoperatively, treating amblyopia and strabismus in a timely manner.
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