Abstract： Optical coherence tomography angiography (OCTA) is a new technology that has been developing in recent years. It can provide high-resolution fundus retinal imaging that is noninvasive and quick. Since the quantitative value of retinal vascular density and the foveal avascular zone can be achieved, this can provide great help for research on early fundus lesions in myopia. This paper reviews the history of OCTA, and summarizes measurement with OCTA and progress in myopia research on fundus retinal blood flow changes and the factors that influence it in detail, including progress on the diagnosis of pathological myopia.
王雪晴 夏丽坤. OCTA测量近视人群视网膜血管密度及中心凹无血管区的研究进展[J]. 中华眼视光学与视觉科学杂志, 2021, 23(2): 150-155.
Xueqing Wang, Likun Xia. Advances in OCTA Measurement of Retinal Vascular Density and the Foveal Avascular Zone in Myopia. Chinese Journal of Optometry Ophthalmology and Visual science, 2021, 23(2): 150-155. DOI: 10.3760/cma.j.cn115909-20191219-00335
Ohno-Matsui K, Lai TY, Lai CC, et al. Updates of pathologic myopia. Prog Retin Eye Res, 2016, 52: 156-187. DOI: 10.1016/ j.preteyeres.2015.12.001.
[2]
Holden BA, Fricke TR, Wilson DA, et al. Global prevalence of myopia and high myopia and temporal trends from 2000 through 2050. Ophthalmology, 2016, 123(5): 1036-1042. DOI: 10.1016/ j.ophtha.2016.01.006.
[3]
Lin LL, Shih YF, Hsiao CK, et al. Prevalence of myopia in Taiwanese schoolchildren: 1983 to 2000. Ann Acad Med Singapore, 2004, 33(1): 27-33.
[4]
Flitcroft DI, He M, Jonas JB, et al. IMI-defining and classifying myopia: A proposed set of standards for clinical and epidemiologic studies. Invest Ophthalmol Vis Sci, 2019, 60(3): M20-M30. DOI: 10.1167/iovs.18-25957.
[5]
Zhao Q, Yang WL, Wang XN, et al. Repeatability and reproducibility of quantitative assessment of the retinal microvasculature using optical coherence tomography angiography based on optical microangiography. Biomed Environ Sci, 2018, 31(6): 407-412. DOI: 10.3967/bes2018.054.
[6]
Huang D, Swanson EA, Lin CP, et al. Optical coherence tomography. Science, 1991, 254(5035): 1178-1181. DOI: 10.1126/science.1957169.
[7]
Izatt JA, Kulkarni MD, Yazdanfar S, et al. In vivo bidirectional color Doppler flow imaging of picoliter blood volumes using optical coherence tomography. Opt Lett, 1997, 22(18): 1439- 1441. DOI: 10.1364/ol.22.001439.
[8]
White B, Pierce M, Nassif N, et al. In vivo dynamic human retinal blood flow imaging using ultra-high-speed spectral domain optical coherence tomography. Opt Express, 2003, 11(15): 3490-3497. DOI: 10.1364/oe.11.003490.
[9]
Barton J, Stromski S. Flow measurement without phase information in optical coherence tomography images. Opt Express, 2005, 13(14): 5234-5239. DOI: 10.1364/opex.13. 005234.
[10]
Wang RK, Jacques SL, Ma Z, et al. Three-dimensional optical angiography. Opt Express, 2007, 15(7): 4083-4097. DOI: 10.1364/oe.15.004083.
[11]
Wang RK, An L, Saunders S, et al. Optical microangiography provides depth-resolved images of directional ocular blood perfusion in posterior eye segment. J Biomed Opt, 2010, 15(2): 020502. DOI: 10.1117/1.3353958.
[12]
Jia Y, Tan O, Tokayer J, et al. Split-spectrum amplitudedecorrelation angiography with optical coherence tomography. Opt Express, 2012, 20(4): 4710-4725. DOI: 10.1364/oe.20. 004710.
Gorczynska I, Migacz JV, Zawadzki RJ, et al. Comparison of amplitude-decorrelation, speckle-variance and phase-variance OCT angiography methods for imaging the human retina and choroid. Biomed Opt Express, 2016, 7(3): 911-942. DOI: 10.1364/BOE.7.000911.
Bonini Filho MA, de Carlo TE, Ferrara D, et al. Association of choroidal neovascularization and central serous chorioretinopathy with optical coherence tomography angiography. JAMA Ophthalmol, 2015, 133(8): 899-906. DOI: 10.1001/ jamaophthalmol.2015.1320.
[17]
Fan H, Chen HY, Ma HJ, et al. Reduced macular vascular density in myopic eyes. Chin Med J (Engl), 2017, 130(4): 445- 451. DOI: 10.4103/0366-6999.199844.
[18]
Grudzińska E, Modrzejewska M. Modern diagnostic techniques for the assessment of ocular blood flow in myopia: Current state of knowledge. J Ophthalmol, 2018, 2018: 4694789. DOI: 10.1155/2018/4694789.
[19]
Man RE, Lamoureux EL, Taouk Y, et al. Axial length, retinal function, and oxygen consumption: A potential mechanism for a lower risk of diabetic retinopathy in longer eyes. Invest Ophthalmol Vis Sci, 2013, 54(12): 7691-7698. DOI: 10.1167/ iovs.13-12412.
[20]
Mo J, Duan A, Chan S, et al. Vascular flow density in pathological myopia: an optical coherence tomography angiography study. BMJ Open, 2017, 7(2): e013571. DOI: 10.1136/ bmjopen-2016-013571.
[21]
Li M, Yang Y, Jiang H, et al. Retinal Microvascular network and microcirculation assessments in high myopia. Am J Ophthalmol, 2017, 174: 56-67. DOI: 10.1016/j.ajo.2016.10.018.
[22]
Milani P, Montesano G, Rossetti L, et al. Vessel density,retinal thickness, and choriocapillaris vascular flow in myopic eyes on OCT angiography. Graefes Arch Clin Exp Ophthalmol, 2018, 256 (8): 1419-1427. DOI: 10.1007/s00417-018-4012-y.
[23]
Cheng D, Chen Q, Wu Y, et al. Deep perifoveal vessel density as an indicator of capillary loss in high myopia. Eye, 2019, 33(12):1961-1968. DOI: 10.1038/s41433-019-0573-1.
[24]
Wang X, Kong X, Jiang C, et al. Is the peripapillary retinal perfusion related to myopia in healthy eyes? A prospective comparative study. BMJ Open, 2016, 6(3): e010791. DOI: 10.1136/bmjopen-2015-010791.
[25]
He J, Chen Q, Yin Y, et al. Association between retinal microvasculature and optic disc alterations in high myopia. Eye (Lond), 2019, 33(9): 1494-1503. DOI: 10.1038/s41433-019- 0438-7.
[26]
Go??biewska J, Bia?a-Gosek K, Czeszyk A, et al. Optical coherence tomography angiography of superficial retinal vessel density and foveal avascular zone in myopic children. PLoS One, 2019, 14(7): e0219785. DOI: 10.1371/journal. pone.0219785.
[27]
Yang Y, Wang J, Jiang H, et al. Retinal microvasculature alteration in high myopia. Invest Ophthalmol Vis Sci, 2016, 57(14): 6020-6030. DOI: 10.1167/iovs.16-19542.
[28]
Venkatesh R, Sinha S, Gangadharaiah D, et al. Retinal structuralvascular-functional relationship using optical coherence tomography and optical coherence tomography-angiography in myopia. Eye Vis (Lond), 2019, 6: 8. DOI: 10.1186/s40662-019- 0133-6.
[29]
Li Y, Miara H, Ouyang P, et al. The comparison of regional RNFL and fundus vasculature by OCTA in Chinese myopia population. J Ophthalmol, 2018, 2018: 3490962. DOI: 10.1155/2018/3490962.
Tan CS, Lim LW, Chow VS, et al. Optical coherence tomography angiography evaluation of the parafoveal vasculature and its relationship with ocular factors. Invest Ophthalmol Vis Sci, 2016, 57(9): OCT224-OCT234. DOI: 10.1167/iovs.15-18869.
Yu J, Gu R, Zong Y, et al. Relationship between retinal perfusion and retinal thickness in healthy subjects: An optical coherence tomography angiography study. Invest Ophthalmol Vis Sci, 2016, 57(9): 204-210. DOI: 10.1167/iovs.15-18630.
[34]
Hassan M, Sadiq MA, Halim MS, et al. Evaluation of macular and peripapillary vessel flow density in eyes with no known pathology using optical coherence tomography angiography. Int J Retina Vitreous, 2017, 3: 27. DOI: 10.1186/s40942-017-0080-0.
[35]
Abdolrahimzadeh S, Parisi F, Plateroti AM, et al. Visual acuity, and macular and peripapillary thickness in high myopia. Curr Eye Res, 2017, 42(11): 1468-1473. DOI: 10.1080/02713683. 2017.1347692.
[36]
Yang S, Zhou M, Lu B, et al. Quantification of macular vascular density using optical coherence tomography angiography and its relationship with retinal thickness in myopic eyes of young adults. J Ophthalmol, 2017, 2017: 1397179. DOI: 10.1155/2017/1397179.
[37]
Leng Y, Tam EK, Falavarjani KG, et al. Effect of age and myopia on retinal microvasculature. Ophthalmic Surg Lasers Imaging Retina, 2018, 49(12): 925-931. DOI: 10.3928/23258160- 20181203-03.
Yu J, Jiang C, Wang X, et al. Macular perfusion in healthy Chinese: An optical coherence tomography angiogram study. Invest Ophthalmol Vis Sci, 2015, 56(5): 3212-3217. DOI: 10.1167/iovs.14-16270.
[40]
Iafe NA, Phasukkijwatana N, Chen X, et al. Retinal capillary density and foveal avascular zone area are age-dependent: Quantitative analysis using optical coherence tomography angiography. Invest Ophthalmol Vis Sci, 2016, 57(13): 5780- 5787. DOI: 0.1167/iovs.16-20045.
[41]
Shahlaee A, Pefkianaki M, Hsu J, et al. Measurement of foveal avascular zone dimensions and its reliability in healthy eyes using optical coherence tomography angiography. Am J Ophthalmol, 2016, 161: 50-51. DOI: 10.1016/j.ajo.2015.09.026.
[42]
Zong Y, Xu H, Yu J, et al. Retinal vascular autoregulation during Phase IV of the Valsalva maneuver: An optical coherence tomography angiography study in healthy Chinese adults. Front Physiol, 2017, 8: 553. DOI: 10.3389/fphys.2017.00553.
[43]
Al-Sheikh M, Phasukkijwatana N, Dolz-Marco R, et al. Quantitative OCT angiography of the retinal microvasculature and the choriocapillaris in myopic eyes. Invest Ophthalmol Vis Sci, 2017, 58(4): 2063-2069. DOI: 10.1167/iovs.16-21289.
[44]
Mo J, Duan AL, Chan SY, et al. Application of optical coherence tomography angiography in assessment of posterior scleral reinforcement for pathologic myopia. Int J Ophthalmol, 2016, 9(12): 1761-1765. DOI:10.18240/ijo.2016.12.10.
[45]
Luo M, Du H, Ding H, et al. Peripheral retinal neovascularization secondary to highly myopic superficial Retinoschisis: A case report. BMC Ophthalmol, 2020, 20(1): 25. DOI: 10.1186/ s12886-020-1308-6.
[46]
Bruyère E, Miere A, Cohen SY, et al. Neovascularization secondary to high myopia imaged by optical coherence tomography angiography. Retina, 2017, 37(11): 2095-2101. DOI: 10.1097/IAE.0000000000001456.
[47]
Querques L, Giuffrè C, Corvi F, et al. Optical coherencetomography angiography of myopic choroidal neovascularisation. Br J Ophthalmol, 2017, 101(5): 609-615. DOI: 10.1136/ bjophthalmol-2016-309162. [48] Chhablani J, Deepa MJ, Tyagi M, et al. Fluorescein angiography and optical coherence tomography in myopic choroidal neovascularization. Eye (Lond), 2015, 29(4): 519-524. DOI: 10.1038/eye.2014.345.
[49]
Cheng Y, Li Y, Huang X, et al. Application of optical coherence tomography angiography to assess anti-vascular endothelial growth factor therapy in myopic choroidal neovascularization. Retina, 2019, 39(4): 712-718. DOI: 10.1097/ IAE.0000000000002005.
[50]
Bagchi A, Schwartz R, Hykin P, et al. Diagnostic algorithm utilising multimodal imaging including optical coherence tomography angiography for the detection of myopic choroidal neovascularisation. Eye (Lond), 2019, 33(7): 1111-1118. DOI: 10.1038/s41433-019-0378-2.
[51]
Li M, Jin E, Dong C, et al. The repeatability of superficial retinal vessel density measurements in eyes with long axial length using optical coherence tomography angiography. BMC Ophthalmol, 2018, 18(1): 326. DOI: 10.1186/s12886-018-0992-y.
[52]
Zhang Q, Zhang A, Lee CS, et al. Projection artifact removal improves visualization and quantitation of macular neovascularization imaged by optical coherence tomography angiography. Ophthalmol Retina, 2017, 1(2): 124-136. DOI: 10.1016/j.oret.2016.08.005.
[53]
Costa VP, Harris A, Anderson D, et al. Ocular perfusion pressure in glaucoma. Acta Ophthalmol, 2014, 92(4): e252-e266. DOI: 10.1111/aos.12298.
浙公网安备 33030202001892号