近视发生发展中脉络膜变化的研究进展

doi:10.3760/cma.j.cn115909-20201009-00380

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摘要近年来近视的患病率不断上升，严重影响人们的生活，给社会带来巨大经济负担，针对近视发生发展机制的研究迫在眉睫。随着OCT和其他技术的发展，原本不易观测的脉络膜结构及变化得以清晰展现，脉络膜在近视发生发展中的作用研究逐渐受到人们的重视。现笔者将对近视发生发展过程中脉络膜厚度、血流变化及相关因素的研究进展做一综述，以期在近视的防治方面提供理论依据，为临床治疗方法及策略的制定提供帮助。

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关键词 ：近视, 脉络膜厚度, 脉络膜血流, 相关因素

Abstract：In recent years, myopia's prevalence has continued to rise, which severely affects people's lives and brings a vast social and economic burden. Therefore, it is exceptionally urgent to investigate the onset and developmental mechanisms of myopia. With the development of OCT and other technologies, the structure and changes in the choroid, which are not easily observed, can be shown clearly. The research on the role of the choroid in myopia's onset and progression has gradually attracted people's attention. This article reviews the progress of research on choroidal thickness, blood flow changes, and related factors during myopia's onset and progression to provide a theoretical basis for the prevention and treatment of myopia and to provide guidance for the formulation of clinical treatment methods and strategies.

Key words： myopia choroidal thickness choroidal blood flow related factors

收稿日期: 2020-10-09

PACS:

基金资助:国家自然科学基金项目（81870687）

通讯作者: 谷平（ORCID：0000-0002-0154-1664），Email：guping2009@126.com

引用本文:

代小婵,张静,鞠雅晗,等 .. 近视发生发展中脉络膜变化的研究进展[J]. 中华眼视光学与视觉科学杂志, 2022, 24(5): 395-400. Xiaochan Dai1,Jing Zhang1,Yahan Ju2,et al. Research Progress on Choroid Changes during the Onset and Progression of Myopia. Chinese Journal of Optometry Ophthalmology and Visual science, 2022, 24(5): 395-400. DOI: 10.3760/cma.j.cn115909-20201009-00380

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https://www.cjoovs.com/CN/ 10.3760/cma.j.cn115909-20201009-00380 或 https://www.cjoovs.com/CN/Y2022/V24/I5/395

[1]	Wu LJ, You QS, Duan JL, et al. Prevalence and associated factors of myopia in high-school students in Beijing. PLoS One, 2015, 10(3): e0120764. DOI: 10.1371/journal.pone.0120764.
[2]	Holden BA, Fricke TR, Wilson DA, et al. Global prevalence of myopia and high myopia and temporal trends from 2000 through 2050. Ophthalmology, 2016, 123(5): 1036-1042. DOI: 10.1016/ j.ophtha.2016.01.006.
[3]	Dolgin E. The myopia boom. Nature, 2015, 519(7543): 276- 278. DOI: 10.1038/519276a.
[4]	Kim H, Seo JS, Yoo WS, et al. Factors associated with myopia in Korean children: Korea National Health and nutrition examination survey 2016-2017 (KNHANES VII). BMC Ophthalmol, 2020, 20(1): 31. DOI: 10.1186/s12886-020-1316-6.
[5]	Nickla DL, Wallman J. Themultifunctional choroid. Prog Retin Eye Res, 2010, 29(2): 144-168. DOI: 10.1016/ j.preteyeres.2009.12.002.
[6]	Read SA, Fuss JA, Vincent SJ, et al. Choroidal changes in human myopia: insights from optical coherence tomography imaging. Clin Exp Optom, 2019, 102(3): 270-285. DOI: 10.1111/cxo.12862.
[7]	Sacconi R, Borrelli E, Corbelli E, et al. Quantitative changes in the ageing choriocapillaris as measured by swept source optical coherence tomography angiography. Br J Ophthalmol, 2019, 103(9):1320-1326. DOI: 10.1136/bjophthalmol-2018-313004.
[8]	Zhou H, Dai Y, Shi Y, et al. Age-related changes in choroidal thickness and the volume of vessels and stroma using sweptsource OCT and fully automated algorithms. Ophthalmol Retina, 2020, 4(2): 204-215. DOI: 10.1016/j.oret.2019.09.012.
[9]	Kim M, Kim SS, Koh HJ, et al. Choroidal thickness, age, and refractive error in healthy Korean subjects. Optom Vis Sci, 2014, 91(5): 491-496. DOI: 10.1097/OPX.0000000000000229.
[10]	Bhayana AA, Kumar V, Tayade A, et al. Choroidal thickness in normal Indian eyes using swept-source optical coherence tomography. Indian J Ophthalmol, 2019, 67(2): 252-255. DOI: 10.4103/ijo.IJO_668_18.
[11]	Karapetyan A, Ouyang P, Tang LS, et al. Choroidal thickness in relation to ethnicity measured using enhanced depth imaging optical coherence tomography. Retina, 2016, 36(1): 82-90. DOI: 10.1097/iae.0000000000000654.
[12]	Li XQ, Larsen M, Munch IC. Subfoveal choroidal thickness in relation to sex and axial length in 93 Danish university students. Invest Ophthalmol Vis Sci, 2011, 52(11): 8438-8441. DOI: 10.1167/iovs.11-8108.
[13]	Wang W, He M, Zhong X. Sex-dependent choroidal thickness differences in healthy adults: a study based on original and synthesized data. Curr Eye Res, 2018, 43(6): 796-803. DOI: 10.1080/02713683.2018.1428995.
[14]	Bafiq R, Mathew R, Pearce E, et al. Age, sex, and ethnic variations in inner and outer retinal and choroidal thickness on spectral-domain optical coherence tomography. Am J Ophthalmol, 2015, 160(5): 1034-1043. DOI: 10.1016/ j.ajo.2015.07.027.
[15]	Emeterio Nateras OS, Harrison JM, Muir ER, et al. Choroidal blood flow decreases with age: an MRI study. Curr Eye Res, 2014, 39(10): 1059-1067. DOI: 10.3109/02713683.2014.892997.
[16]	Iwase T, Yamamoto K, Kobayashi M, et al. What ocular and systemic variables affect choroidal circulation in healthy eyes. Medicine (Baltimore), 2016, 95(43): e5102. DOI: 10.1097/ MD.0000000000005102.
[17]	Kavroulaki D, Gugleta K, Kochkorov A, et al. Influence of gender and menopausal status on peripheral and choroidal circulation. Acta Ophthalmol, 2010, 88(8): 850-853. DOI: 10.1111/j.1755-3768.2009.01607.x.
[18]	Scherm P, Pettenkofer M, Maier M, et al. Choriocapillary blood flow in myopic subjects measured with OCT angiography. Ophthalmic Surg Lasers Imaging Retina, 2019, 50(5): e133-e139. DOI: 10.3928/23258160-20190503-13.
[19]	Deng J, Li X, Jin J, et al. Distribution pattern of choroidal thickness at the posterior pole in Chinese children with myopia. Invest Ophthalmol Vis Sci, 2018, 59(3): 1577-1586. DOI: 10.1167/iovs.17-22748.
[20]	Vincent SJ, Collins MJ, Read SA, et al. Retinal and choroidal thickness in myopic anisometropia. Invest Ophthalmol Vis Sci, 2013, 54(4): 2445-2456. DOI: 10.1167/iovs.12-11434.
[21]	Fujiwara A, Shiragami C, Shirakata Y, et al. Enhanced depth imaging spectral-domain optical coherence tomography of subfoveal choroidal thickness in normal Japanese eyes. Jpn J Ophthalmol, 2012, 56(3): 230-235. DOI: 10.1007/s10384-012- 0128-5.
[22]	Liu B, Wang Y, Li T, et al. Correlation of subfoveal choroidal thickness with axial length, refractive error, and age in adult highly myopic eyes. BMC Ophthalmol, 2018, 18(1): 127. DOI: 10.1186/s12886-018-0791-5.
[23]	Jin P, Zou H, Zhu J, et al. Choroidal and retinal thickness in children with different refractive status measured by sweptsource optical coherence tomography. Am J Ophthalmol, 2016, 168: 164-176. DOI: 10.1016/j.ajo.2016.05.008.
[24]	Zhang S, Zhang G, Zhou X, et al. Changes in choroidal thickness and choroidal blood perfusion in guinea pig myopia. Invest Ophthalmol Vis Sci, 2019, 60(8): 3074-3083. DOI: 10.1167/iovs.18-26397.
[25]	Gupta P, Thakku SG, Saw SM, et al. Characterization of choroidal morphologic and vascular features in young men with high myopia using Spectral-domain optical coherence tomography. Am J Ophthalmol, 2017, 177: 27-33. DOI: 10.1016/j.ajo.2017.02.001.
[26]	Shih YF, Horng IH, Yang CH, et al. Ocular pulse amplitude in myopia. J Ocul Pharmacol, 1991, 7(1): 83-87. DOI: 10.1089/ jop.1991.7.83.
[27]	Al-Sheikh M, Phasukkijwatana N, Dolz-Marco R, et al. Quantitative OCT angiography of the retinal microvasculature and the choriocapillaris in myopic eyes. Invest Ophthalmol Vis Sci, 2017, 58(4): 2063-2069. DOI: 10.1167/iovs.16-21289.
[28]	Lam AK, Chan ST, Chan B, et al. The effect of axial length on ocular blood flow assessment in anisometropes. Ophthalmic Physiol Opt, 2003, 23(4): 315-320. DOI: 10.1046/j.1475- 1313.2003.00122.x.
[29]	Wallman J, Winawer J. Homeostasis of eye growth and the question of myopia. Neuron, 2004, 43(4): 447-468. DOI: 10.1016/j.neuron.2004.08.008.
[30]	Wildsoet C, Wallman J. Choroidal and scleral mechanisms of compensation for spectacle lenses in chicks. Vision Res, 1995, 35(9): 1175-1194. DOI: 10.1016/0042-6989(94)00233-c.
[31]	Read SA, Collins MJ, Sander BP. Human optical axial length and defocus. Invest Ophthalmol Vis Sci, 2010, 51(12): 6262- 6269. DOI: 10.1167/iovs.10-5457.
[32]	Chiang ST, Phillips JR, Backhouse S. Effect of retinal image defocus on the thickness of the human choroid. Ophthalmic Physiol Opt, 2015, 35(4): 405-413. DOI: 10.1111/opo.12218.
[33]	Wang D, Chun RK, Liu M, et al. Optical defocus rapidly changes choroidal thickness in schoolchildren. PLoS One, 2016, 11(8): e0161535. DOI: 10.1371/journal.pone.0161535.
[34]	Marcos S, Moreno E, Navarro R. The depth-of-field of the human eye from objective and subjective measurements. Vision Res, 1999, 39(12): 2039-2049. DOI: 10.1016/s0042- 6989(98)00317-4.
[35]	Swarbrick HA. Orthokeratology review and update. Clin Exp Optom, 2006, 89(3):124-143. DOI: 10.1111/j.1444- 0938.2006.00044.x.
[36]	Cho P, Cheung SW. Retardation of myopia in Orthokeratology (ROMIO) study: a 2-year randomized clinical trial. Invest Ophthalmol Vis Sci, 2012, 53(11): 7077-7085. DOI: 10.1167/ iovs.12-10565.
[37]	Hiraoka T, Kakita T, Okamoto F, et al. Long-term effect of overnight orthokeratology on axial length elongation in childhood myopia: a 5-year follow-up study. Invest Ophthalmol Vis Sci, 2012, 53(7): 3913-3919. DOI: 10.1167/iovs.11-8453.
[38]	Santodomingo-Rubido J, Villa-Collar C, Gilmartin B, et al. Myopia control with orthokeratology contact lenses in Spain: refractive and biometric changes. Invest Ophthalmol Vis Sci, 2012, 53(8): 5060-5065. DOI: 10.1167/iovs.11-8005.
[39]	Swarbrick HA, Alharbi A, Watt K, et al. Myopia control during orthokeratology lens wear in children using a novel study design. Ophthalmology, 2015, 122(3): 620-630. DOI: 10.1016/ j.ophtha.2014.09.028.
[40]	Chen Z, Xue F, Zhou J, et al. Effects of Orthokeratology on Choroidal Thickness and Axial Length. Optom Vis Sci, 2016, 93(9): 1064-1071. DOI: 10.1097/OPX.0000000000000894.
[41]	Li Z, Cui D, Hu Y, et al. Choroidal thickness and axial length changes in myopic children treated with orthokeratology. Cont Lens Anterior Eye, 2017, 40(6): 417-423. DOI: 10.1016/ j.clae.2017.09.010.
[42]	Chia A, Lu QS, Tan D. Five-year clinical trial on atropine for the treatment of myopia 2: myopia control with atropine 0.01% eyedrops. Ophthalmology, 2016, 123(2): 391-399. DOI: 10.1016/j.ophtha.2015.07.004.
[43]	Sander BP, Collins MJ, Read SA. The effect of topical adrenergic and anticholinergic agents on the choroidal thickness of young healthy adults. Exp Eye Res, 2014, 128: 181-189. DOI: 10.1016/j.exer.2014.10.003.
[44]	Zhang Z, Zhou Y, Xie Z, et al. The effect of topical atropine on the choroidal thickness of healthy children. Sci Rep, 2016, 6: 34936. DOI: 10.1038/srep34936.
[45]	Chiang ST, Phillips JR. Effect of atropine eye drops on choroidal thinning induced by hyperopic retinal defocus. J Ophthalmol, 2018, 2018: 8528315. DOI: 10.1155/2018/8528315.
[46]	BP S, MJ C, SA R. The interaction between homatropine and optical blur on choroidal thickness. Ophthalmic Physiol Opt, 2018, 38(3): 257-265. DOI: 10.1111/opo.12450.
[47]	Ashby R, Ohlendorf A, Schaeffel F. The effect of ambient illuminance on the development of deprivation myopia in chicks. Invest Ophthalmol Vis Sci, 2009, 50(11): 5348-5354. DOI: 10.1167/iovs.09-3419.
[48]	Lan W, Feldkaemper M, Schaeffel F. Bright light induces choroidal thickening in chickens. OptomVis Sci, 2013, 90(11): 1199-1206. DOI: 10.1097/opx.0000000000000074.
[49]	Xiong S, Sankaridurg P, Naduvilath T, et al. Time spent in outdoor activities in relation to myopia prevention and control: a meta-analysis and systematic review. Acta Ophthalmol, 2017, 95(6): 551-566. DOI: 10.1111/aos.13403.
[50]	Read SA, Collins MJ, Vincent SJ. Light exposure and eye growth in childhood. Invest Ophthalmol Vis Sci, 2015, 56(11): 6779-6787. DOI: 10.1167/iovs.14-15978.
[51]	Wu PC, Chen CT, Lin KK, et al. Myopia prevention and outdoor light intensity in a school-based cluster randomized trial. Ophthalmology, 2018, 125(8): 1239-1250. DOI: 10.1016/ j.ophtha.2017.12.011.
[52]	Read SA. Ocular and environmental factors associated with eye growth in childhood. Optom Vis Sci, 2016, 93(9): 1031-1041. DOI: 10.1097/Opx.0000000000000915.
[53]	Read SA, Pieterse EC, Alonso-Caneiro D, et al. Daily morning light therapy is associated with an increase in choroidal thickness in healthy young adults. Sci Rep, 2018, 8(1): 8200. DOI: 10.1038/s41598-018-26635-7.
[54]	Fuchsjäger-Mayrl G, Polska E, Malec M, et al. Unilateral light-dark transitions affect choroidal blood flow in both eyes. Vision Res, 2001, 41(22): 2919-2924. DOI: 10.1016/s0042- 6989(01)00171-7.
[55]	Ahn J, Ahn SE, Yang KS, et al. Effects of a high level of illumination before sleep at night on chorioretinal thickness and ocular biometry. Exp Eye Res, 2017, 164: 157-167. DOI: 10.1016/j.exer.2017.09.001.
[56]	Gabriel M, Esmaeelpour M, Shams-Mafi F, et al. Mapping diurnal changes in choroidal, Haller's and Sattler's layer thickness using 3-dimensional 1 060-nm optical coherence tomography. Graefes Arch Clin Exp Ophthalmol, 2017, 255(10): 1957-1963. DOI: 10.1007/s00417-017-3723-9.
[57]	Chakraborty R, Read SA, Collins MJ. Diurnal variations in axial length, choroidal thickness, intraocular pressure, and ocular biometrics. Invest Ophthalmol Vis Sci, 2011, 52(8): 5121-5129. DOI: 10.1167/iovs.11-7364.
[58]	Chakraborty R, Read SA, Collins MJ. Monocular myopic defocus and daily changes in axial length and choroidal thickness of human eyes. Exp Eye Res, 2012, 103: 47-54. DOI: 10.1016/j.exer.2012.08.002.
[59]	Moderiano D, Do M, Hobbs S, et al. Influence of the time of day on axial length and choroidal thickness changes to hyperopic and myopic defocus in human eyes. Exp Eye Res, 2019, 182: 125-136. DOI: 10.1016/j.exer.2019.03.019.
[60]	Nickla DL. Ocular diurnal rhythms and eye growth regulation: where we are 50 years after Lauber. Exp Eye Res, 2013, 114: 25-34. DOI: 10.1016/j.exer.2012.12.013.