Changes of Dry Eye-Related Parameters after Posterior Chamber Phakic Refractive Lens Implantation
Zhuxuan Yan1, Zhenguo Yan2, Yang Lyu3
1The First Clinical Medical School, Gansu University of Chinese Medicine, Lanzhou 730000, China
2 Lanzhou Huaxia Eye Hospital, Lanzhou 730000, China
3 Ophthalmic Center, the 940 Hospital of Joint Service Support Forces of the Chinese People's Liberation Army, Lanzhou 730000, China
Abstract：Objective: To determine the alternation of dry eye-related parameters in patients after posterior chamber phakic refractive lens (PC-PRL) implantation. Methods: This was a case serial study. Twenty-one patients (39 eyes) who underwent PC-PRL implantation at Lanzhou Huaxia Eye Hospital from January 2021 to June 2022 and completed 3-month follow-up were selected in this study. Dry eye-related examinations, including ocular surface disease index (OSDI) questionnaire score, noninvasive frst breakup time (NIF-BUT), noninvasive average breakup time (NIA-BUT), tear meniscus height (TMH), meibomian gland loss , and Schirmer test (S t), were performed preoperatively and at 1 week, 1 month, and 3 months postoperatively. Repeated measures ANOVA was used to compare the repeated-measures data, and LSD-t tests were used for pairwise comparisons. Results: OSDI questionnaire scores were signifcantly different before and after surgery (F=7.13, P=0.008). Compared with before surgery, OSDI questionnaire scores signifcantly increased at 1 week (t=-4.03, P<0.001), but had no signifcant difference at 1 month and 3 months after surgery (P>0.05). NIF-BUT and NIA-BUT were also significantly different before and after surgery (F=28.85, P<0.001; F=33.48, P<0.001). Compared with before surgery, NIF-BUT signifcantly decreased at 1 week and 1 month after surgery (t=3.65, P=0.001; t=3.77, P=0.001), but had no signifcant difference at 3 months after surgery (t=0.75, P=0.459). Compared with before surgery, NIA-BUT significantly decreased at 1 week and 1 month after surgery (t=3.26, P=0.002; t=3.94, P<0.001), but had no significant difference at 3 months after surgery (t=0.83, P=0.372). There was no significant difference in TMH, meibomian gland loss, and S t at each time point after operation compared with that before operation(all P>0.05). Conclusions: PC-PRL affected the stability of the ocular surface tear flm in the early postoperative period, and the patients developed different degrees of dry eye symptoms, and all dry eye-related parameters returned to the preoperative level basically at 3 months after surgery.
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