Effect of Scleral Lens on Central Corneal Thickness and Corneal Endothelial Cells in Patients with Refractive Error
Aiqin Xu1, Bichi Chen2, Li Tian1, Shanxiao Liu1, Lu Liu1, Jun Jiang1
1National Clinical Research Center for Ocular Diseases, Eye Hospital, Wenzhou Medical University, Wenzhou 325027, China
2Vision X Medical Technology Co., Ltd., Shanghai 201114, China
Abstract：Objective: To investigate the changes in central corneal thickness (CCT) and corneal endothelial cells in patients with refractive error after short-term wearing of the scleral lens (SL) and the infuencing factors. Methods: Prospective clinical study. Twenty-one subjects who received SL for refractive error correction in the Eye Hospital of Wenzhou Medical University from June 2021 to September 2021 were randomly selected. The CCT was measured by swept-source optical coherence tomography at different time points on the frst day after wearing SL (immediately, 30 minutes, 1 hour, 2 hours, and 4 hours after lens insertion) and after three months (immediately and 4 hours after lens insertion). The corneal endothelial cell density and pleomorphic grading were measured using the endothelial cell enumerator before and after 3 months. Repeated measures analysis of variance, paired t-test and Wilcoxon rank sum test were used to analyze the changes of each parameter before and after wearing scleral lens, and multiple linear regression was used to analyze the infuencing factors. Results: The CCT gradually increased with the extension of wearing time. At 30 minutes, 1 hour, 2 hours, and 4 hours on the frst day after wearing SL, the percentage increase of CCT was 1.37%, 1.39%, 1.49%, and 1.91%, respectively, and the difference was statistically signifcant compared with the initial CCT before wearing the lens (F=5.40, P=0.004). After 3 months, the percentage increase of CCT was 1.08% after wearing 4 hours comparing with the initial CCT on the same day (t=-3.33, P=0.003). There was no signifcant difference between the initial CCT (529±27 μm) on the frst day and the initial CCT (529±30 μm) after 3 months (P>0.05). The differences in corneal endothelial cell density and pleomorphism before and after wearing SL for 3 months were not signifcantly (all P>0.05). There was no correlation between the amount of CCT thickening and initial post-lens tear thickness, spherical equivalent, age, and gender (all P>0.05). Conclusions: Short-term wearing of SL would cause an increase in CCT, and the amount of thickening increased with the extension of wearing time. However, the percentage increase of CCT after wearing 4 hours was less than the corneal physiological edema. After 3 months of lens wearing, the initial CCT on this day returned to the initial level before 3 months. There was no signifcant change in CCT after 4 hours of continuous wearing on the frst day and 3 months later. Meanwhile, short-term wearing of SL had no effect on the morphology of corneal endothelial cells.
许爱琴, 陈碧池, 田丽, 等. 巩膜镜对屈光不正患者中央角膜厚度和内皮细胞的影响[J]. 中华眼视光学与视觉科学杂志, 2023, 25(9): 678-682.
Shanxiao Liu1, Lu Liu1, Jun Jiang1,et al. Effect of Scleral Lens on Central Corneal Thickness and Corneal Endothelial Cells in Patients with Refractive Error . Chinese Journal of Optometry Ophthalmology and Visual science, 2023, 25(9): 678-682. DOI: 10.3760/cma.j.cn115909-20230409-00101
浙公网安备 33030202001892号