Objective To investigate the relationship between choroidal thickness （CT） and equivalent power and intraocular pressure （IOP） in a myopic Chinese population. Methods This cross-sectional study included 118 myopic patients. Choroidal thickness was measured at the fovea and 0.5， 1.0 and 2.5 mm temporal， nasal， superior， and inferior to the fovea using spectral-domain OCT. IOP was measured with a non-contact tonometer. Refractive error was described as equivalent power. The data of the right eyes were analyzed with a one-way ANOVA， correlation analysis， and linear regression analysis. Results CT at 1.0 and 2.5 mm nasal to the fovea was thinner than CT at the fovea and the three other directions （P<0.01）. CT at the fovea and 0.5 and 1.0 mm temporal， nasal， superior， and inferior to the fovea were negatively correlated with equivalent power （r=-0.330， -0.207， -0.205， -0.272， -0.317， -0.283， -0.269， -0.212， -0.252； P<0.05）. No correlation was found between equivalent power and CT at 2.5 mm temporal， nasal， superior， and inferior to the fovea. There was no correlation between CT at 2.5 mm nasal to the fovea and IOP. CT at other locations was negatively correlated with IOP （r=-0.295， -0.358， -0.459， -0.675， -0.315， -0.285， -0.314， -0.322， -0.295， -0.392， -0.336， -0.317； P<0.01）. The formula obtained with multiple linear regression analysis was as follows： CT at the fovea （μm）=345.22-4.54×IOP （mmHg）-7.57× equivalent power （D） （F=12.51， P<0.01）. Conclusion CT at the fovea and close to the fovea became thinner as equivalent power increased， but CT away from the fovea was not affected by equivalent power. CT at most locations became thicker as IOP decreased.
李敏,程慧勤,苑影,王佳,柯碧莲. 近视人群脉络膜厚度与屈光度及眼压的关系[J]. 中华眼视光学与视觉科学杂志, 2014, 16(6): 350-353.
Li Min,Cheng Huiqin,Yuan Ying,Wang Jia,Ke Bilian. The relationship between choroidal thickness and equivalent power and intraocular pressure in a myopic population. Chinese Journal of Optometry Ophthalmology and Visual Science, 2014, 16(6): 350-353. DOI: 10.3760/cma.j.issn.1674-845X.2014.06.007
Saw SM， Gazzard G， Shih-Yen EC， et al. Myopia and associated pathological complications[J]. Ophthalmic Physiol Opt，2005，25：381-391.
[2]
Flores-Moreno I， Lugo F， Duker JS， et al. The relationship between axial length and choroidal thickness in eyes with high myopia[J]. Am J Ophthalmol，2013，155：314-319.
[3]
Fujiwara T， Imamura Y， Margolis R， et al. Enhanced depth imaging optical coherence tomography of the choroid in highly myopic eyes[J]. Am J Ophthalmol，2009，148：445-450.
[4]
Wong TY， Klein BE， Klein R， et al. Refractive errors， intraocular pressure， and glaucoma in a white population[J]. Ophthalmology，2003，110：211-217.
[5]
Chen JC， Schmid KL， Brown B， et al. The effect of a beta-adrenoceptor antagonist on accommodative adaptation in HongKong children[J]. Curr Eye Res，2005，30：179-188.
[6]
Usui S， Ikuno Y， Uematsu S， et al. Changes in axial length and choroidal thickness after intraocular pressure reduction resulting from trabeculectomy[J]. Clin Ophthalmol，2013，7：1155-1161.
[7]
Kara N， Baz O， Altan C， et al. Changes in choroidal thickness， axial length， and ocular perfusion pressure accompanying successful glaucoma filtration surgery[J]. Eye （Lond），2013，27：940-945.
[8]
Vincent SJ， Collins MJ， Read SA， et al. Retinal and choroidal thickness in myopic anisometropia[J]. Invest Ophthalmol Vis Sci，2013，54：2445-2456.
[9]
Ohno-Matsui K， Akiba M， Modegi T， et al. Association between shape of sclera and myopic retinochoroidal lesions in patients with pathologic myopia[J]. Invest Ophthalmol Vis Sci，2012，53：6046-6061.
[10]
Jonas JB， Xu L. Histological changes of high axial myopia[J]. Eye （Lond），2013，28：113-117.
[11]
Zhang Z， He X， Zhu J， et al. Macular measurements using optical coherence tomography in healthy Chinese school age children[J]. Invest Ophthalmol Vis Sci，2011，52：6377-6383.
[12]
Kamiya K， Aizawa D， Igarashi A， et al. Effects of antiglaucoma drugs on refractive outcomes in eyes with myopic regression after laser in situ keratomileusis[J]. Am J Ophthalmol，2008， 145：233-238.
[13]
Mousa AR， Brede?/sxean V， Costin D. The role of ocular perfusion pressure in the course of primary open angle glaucoma in patients with systemic hypertension[J]. Rev Med Chir Soc Med Nat Iasi，2012，116：162-167.
[14]
Yang SJ， Han YH， Song GI， et al. Changes of choroidal thickness， intraocular pressure and other optical coherence tomographic parameters after haemodialysis[J]. Clin Exp Optom，2013，96：494-499.
[15]
Maul EA， Friedman DS， Chang DS， et al. Choroidal thickness measured by spectral domain optical coherence tomography： factors affecting thickness in glaucoma patients[J]. Ophthalmology，2011，118：1571-1579.
[16]
Ngo S， Harris A， Siesky BA， et al. Blood pressure， ocular perfusion pressure， and body mass index in glaucoma patients[J]. Eur J Ophthalmol，2013，23：664-669.
[17]
Lee TE， Yoo C， Kim YY. Effects of different sleeping postures on intraocular pressure and ocular perfusion pressure in healthy young subjects[J]. Ophthalmology，2013，120：1565-1570.
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