Objective To investigate the effects of signal strength (SS) on the measurement of macular thickness and volume in normal volunteers with spectral-domain optical coherence tomography (OCT). Methods This was a retrospective cohort study. The retinal thickness of 109 normal volunteers was measured by a cubic scan of the macular, Cirrus OCT. All eyes were divided into subgroups: group A1 (identical SS ≥7 in both eyes), group A2 (identical SS <7 in both eyes), group B1 (different SS≥7 in both eyes), group B2 (different SS<7 in both eyes) and group B3 (SS≥7 in one eye, SS<7 in the other eye). Macular thickness and volume were measured in the subgroups. ANOVA and paired t test were used to analyze. Results There were no differences in macular thickness and volume for both eyes in group A1, group A2 and group B1. There was a significant positive correlation between SS and macular cubic volume in group B2 (t=-2.776, P<0.05). However, there was a significant negative correlation between SS and macular cubic volume and average macular thickness in group B3 (t=2.871, P<0.05; t=3.210, P<0.05). Conclusion Signal strength is one of the determi-nants of macular thickness measurement with spectral-domain optical coherence tomography.
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