Objective To evaluate the clinical outcome of epipolis LASIK （Epi-LASIK） combined with UVA/riboflavin crosslinking in patients with mild to moderate keratoconus. Methods A total of 31 eyes in 18 patients with mild to moderate keratoconus were recruited for this prospective study. Epi-LASIK was performed using the Ziemers Microkeratome and Wavelight EX500 excimer laser. UVA/riboflavin crosslinking was applied immediately after Epi-LASIK. UCVA and BCVA and corneal topography were assessed before treatment and at 1， 3， and 6 months after treatment. Results The average K value in the center of the cornea was 46.65±2.91 D before treatment， and was 42.94±3.88 D， 41.72±4.38 D and 41.99±3.84 D at 1， 3， and 6 months after treatment. Visual acuity was 0.70±0.24 before treatment， and 0.09±0.16， 0.06±0.20 and -0.06±0.03 at 1， 3， and 6 months after treatment. There was significant improvement in UCVA （F=3.39， P<0.01） and in the reduction of the K value （F=3.57， P<0.05） when measurements before treatment were compared to measurements after treatment at months 1， 3， and 6. Conclusion Epi-LASIK combined with UVA/riboflavin crosslinking is effective in improving visual acuity in mild to moderate keratoconus patients.
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