Objective Evaluate the safety and effectiveness of transepithelial， very high fluence accelerated corneal collagen cross-linking （A-CXL） in primary keratoconus. Methods Self-control study. Thirteen primary keratoconus eyes of 13 patients were treated with transepthelial， very high fluence A-CXL with a UVA intensity of 45 mW/cm2， an irradiation time of 2 min 40 s， and a total energy of 7.2 J/cm2. Routine ophthalmologic examination， UCVA， BCVA， refractive error， corneal keratometry， anterior and posterior elevation （AE and PE）， index of vertical asymmetry （IVA）， minimum corneal thickness （CT）， compensated intraocular pressure （IOPcc）， endothelial cell density （ECD） were evaluated pre-operatively and 7-day， 1-month， 3-month， 6-month， 12-month post-operatively. Results The UCVA （F=6.111， P＜0.01） and BCVA （F=9.734， P＜0.01） showed a statistically significant improvement by 12-month post-operatively. The decrease in spherical lens （F=5.871， P＜0.05）， steeper K-value （F=19.651， P＜0.05）， Kmax （F=3.253， P＜0.05）， AE （F=23.958， P＜0.01）， PE （F=20.832， P＜0.01） and IVA （F=4.068， P＜0.05） were statistically significant. CT （F=4.180， P＞0.05）， ECD （F=1.812， P＞0.05） and IOPcc （F=0.332， P＞0.05） were without significant change. Conclusion Transepithelial， very high fluence A-CXL is safe and effective in treating primary keratoconus.
陈世豪,李旖旎,张佳,丁萍,王勤美. 高辐照度快速经上皮角膜胶原交联术治疗原发性圆锥角膜[J]. 中华眼视光学与视觉科学杂志, 2015, 17(3): 152-155.
Chen Shihao,Li Yini,Zhang Jia,Ding Ping,Wang Qinmei. Pilot study of transepithelial， very high fluence accelerated corneal collagen cross-linking in primary keratoconus. Chinese Journal of Optometry Ophthalmology and Visual science, 2015, 17(3): 152-155. DOI: 10.3760/cma.j.issn.1674-845X.2015.03.006
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