Objective To measure the quality of life (QOL) of Chinese patients after LASIK and to analyze the factors that influence postoperative QOL. Methods A Chinese version of the Quality of life impact of refractive correction (QIRC) questionnaire was used to survey 115 patients before and 3 months after LASIK. The questionnaire included symptoms, visual and physiological function, social activity, mental state and psychological assessment. All participants were 18～40 years old. There were 64 females and 51 males in the patient population, 70 patients with low or medium status and 45 with high or very high status. The change in QOL was analyzed by paired-sample t test and influencing factors were analyzed by Logistic regression. Results The overall QOL score for patients improved from 39.15±4.23 to 41.78±4.76 (t=-4.63, P<0.01) after LASIK surgery. There was no significant difference in the change in QOL when corrective error status (t=1.53, P=0.22), gender (t=1.83, P=0.58) and age (t=1.73, P=0.75) were compared. Logistic regression analysis showed that the higher QOL score for patients had significantly increased odds with eye protection [odds ratio (OR)=5.93, 95% confidence interval (CI) 1.57-22.36], fewer complications (OR=15,13, 95% CI 2.57-88.94), little concern about cost (OR=7.80, 95% CI 1.66-36.71), convenience (OR= 10.36, 95% CI 2.44-44.05), feeling complimented (OR=3.90, 95% CI 1.08-14.13) and confident (OR=12.73, 95% CI 2.97-54.57). Preoperative QOL (OR=-0.07, 95% CI -0.16-2.86), preoperative refraction (OR= 0.57, 95% CI 0.12-2.74), age (OR=0.83, 95% CI 0.11-6.17), gender (OR=20.50, 95% CI 0.85-494.06) and educational background (OR=0.17, 95% CI 0.03-0.99) showed no signifi- cant association with postoperative QOL. Conclusion Significant QOL improvements are found in the majority of LASIK patients. Eye protection, fewer complications, cost, convenience, feeling compli- mented and confident are factors that influenced postoperative QOL in patients.