Objective To evaluate the effects of deproteinized calfblood extract eye gel on central corneal sensitivity (CCC) after LASIK and LASEK. Methods Ninty seven eyes with myopia [-1.5 to -12.5 D, mean (-6.76±2.53)D] underwent LASIK or LASEK were divided into four groups: the first group was given deproteinized calfblood extract eye gel after LASEK, the second group was not given deproteinized calfblood extract eye gel after LASEK, the third group was given depro- teinized calfblood extract eye gel after LASIK, the fourth group was not given deproteinized calfblood extract eye gel after LASIK. There were no difference in age and refraction of each group. Flurometholone was routine used after surgery among four groups, and deproteinized calfblood extract eye gel was used at the first day of postoperation in the treatment group, three times a day, for three months. CCC were observed preoperatively and 1 months and 3 months postoperatively. The ob-tained data were analyzed with independent samples t test and paired t test of SPSS 11.0 statistical software. Results CCC were reduced in the early period time after LASIK and LASEK. At 1 month postoperatively, CCC sensation with deproteinized calfblood extract eye gel treatment was better than that without deproteinized calfblood extract eye gel treatment after LASIK, there was significant dif-ference between two groups (t=2.25, P<0.05). At 3 month postoperatively, CCC sensation of two groups didn't recover, there was no difference between two groups (t=2.01, P>0.05). At 1 month postoperatively, CCC sensation with deproteinized calfbiood extract eye gel treatment was better than that without deproteinized calfblood extract eye gel treatment after LASEK, there was significant dif-ference between two groups (t=3.54, P<0.01). At 3 month postoperatively, CCC sensation of two groups didn't recover, there was no difference between two groups (t=1.79, P>0.05). Conclusion In the early period after LASIK and LASEK, deproteinized calfblood extract eye gel can accelerate the recovery o