Abstract：Objective: To observe and evaluate the pain response in patients with diabetic retinopathy (DR) treated with panretinal laser photocoagulation (PRP). Methods: This was a retrospective case series study. Fifty-five patients aged 45-72 years (average age: 60.7±7.9 years old) with DR who were treated with PRP from July 2019 to December 2019 were recruited at Taizhou Municipal Hospital. After PRP, the numerical rating scale was used to evaluate the pain response, and the pain responses from peripheral retinal photocoagulation and posterior polar retinal photocoagulation were compared by Spearman correlation analysis. The pain score was statistically analyzed by the Fisher exact test. Results: In this study, age and gender had no effect on the patient's pain response (correlation coefficient r=-0.58, P=0.338; r=0.06, P=0.305). There was no significant difference in pain response between the four quadrants (upper, lower, nasal, temporal) for PRP (P=0.763), but the pain score of the posterior pole was lower than that of peripheral retina (P<0.001). Conclusions: The induced pain response of the posterior pole was milder than that of the peripheral retina in patients with diabetic retinopathy during PRP. The areas with no pain or relatively mild pain from laser photocoagulation should be preferentially considered by doctors.
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