Schlemm管为基础的青光眼内引流手术术后眼压分布特征

doi:10.3760/cma.j.cn115909-20201020-00403

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Abstract Objective: To analyze the intraocular pressure (IOP) distribution characteristics after successful Schlemm's canal-based internal filtration surgery. Methods: In this retrospective series of case study, patients were collected from the Schlemm's canal-based surgery study (including canaloplasty and penetrating canaloplasty) in the Eye Hospital, Wenzhou Medical University during June 2015 to January 2019. Statistical analysis was carried out for those who met the inclusion criteria: Follow-up≥6 months and the postoperative IOP during the last follow-up was ≤21 mmHg (1 mmHg=0.133 kPa) without medication. IOP of different types were compared by one-way ANOVA. Results: A total of 204 patients (236 eyes) were enrolled in the statistical analysis. All 236 eyes had a mean preoperative IOP of (33.4±12.1)mmHg and mean glaucoma medication use of (2.7±1.2). Postoperative IOP data formed a normal distribution, with a mean IOP of (13.9±3.3)mmHg. There was no eye with an postoperative IOP below 5 mmHg. Postoperative IOP of patients with different types of glaucoma (primary open-angle glaucoma, primary angle-closure glaucoma, secondary glaucoma, and congenital glaucoma) all formed normal distribution, and the mean IOP were (13.9± 3.2)mmHg, (14.5±3.0)mmHg, (14.0±3.3)mmHg, and (13.2±3.7)mmHg, respectively, with no statistically significant difference between the groups (F=1.011, P=0.289). In primary open-angle glaucoma eyes, target IOP was achieved in 82.4% of early glaucoma, 81.8% moderate glaucoma and 36.8% advanced glaucoma. Conclusions: The average IOP after Schlemm's canal-based internal filtration surgery is about 14 mmHg. Target IOP is achieved in about 80% of eyes in primary openangle glaucoma with early-stage and moderate-stage and one-third of eyes with advanced stage.

Key words： Schlemm's canal glaucoma internal filtration surgery intraocular pressure distribution

Received: 20 October 2020

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Fund: National Key Research and Development Project (2020YFC2008204); Zhejiang Province Health Innovation Talents Project (2016025); Zhejiang Province University Leading Talents Training Program (2020099)

Corresponding Authors: Yuanbo Liang, Eye Hospital, Wenzhou Medical University, Glaucoma Research Institute of Wenzhou Medical University, Wenzhou 325027, China; The National Clinical Research Center for Ocular Diseases of China, Wenzhou 325027, China (Email: yuanboliang@126.com)

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https://www.cjoovs.com/EN/10.3760/cma.j.cn115909-20201020-00403 OR https://www.cjoovs.com/EN/Y2021/V23/I6/409

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