糖尿病视网膜病变不同分期角膜及角膜上皮厚度变化

doi:10.3760/cma.j.cn115909-20210305-00088

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Abstract Objective: To analyze the cornea and corneal epithelial thickness in different stages of diabetic patients.

Methods: This was a serial case study. A total of 146 patients (151 eyes) were enrolled in the study groups.

There were 48 eyes healthy eyes in the normal group, 53 eyes with non-proliferative diabetic retinopathy

were in the NPDR group, and 50 eyes with proliferative diabetic retinopathy were in the PDR group. All

patients were recruited from Shanxi Eye Hospital from January 1, 2018 to January 31, 2020. Using anterior

segment optical coherence tomography (AS-OCT) to observe the thickness changes in a 9 mm area of

the cornea and corneal epithelium in the 3 groups of patients: the NPDR, PDR, and normal groups. An

independent one-way analysis of variance were used to compare the data for the three groups. Results:

There were no differences in the anterior keratometer and posterior keratometer of central cornea and

central corneal thickness between the three groups (F=1.84, P=0.16; F=1.88, P=0.16; F=1.96, P=0.15).

The central corneal epithelial thickness in the healthy eyes group was higher than for the other two groups

(P<0.05). No difference was found between the NPDR group and the PDR group for corneal epithelial

thickness, but the corneal epithelial thickness in the healthy eyes group was different from the other two

groups. There were significant differences in corneal epithelial thickness between the normal group and

NPDR group (P<0.05) and between the normal group and PDR group (P<0.05). There were significant

differences in corneal epithelial thickness between the NPDR group and PDR group in the S5 mm, SN5 mm,

ST5 mm, and T7 mm areas (P<0.05), but no differences in the other areas. Conclusions: The thickness of the

corneal epithelium in patients can be one of the screening methods for different stages of diabetic patients.

Key words： optical coherence tomography')" href="#"> optical coherence tomography diabetic retinopathy')" href="#">diabetic retinopathy cornea')" href="#">cornea corneal epithelial')" href="#">corneal epithelial

Received: 05 March 2021

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Corresponding Authors: Haining Zhang, Shanxi Eye Hospital, Taiyuan 030006, China (Email: 88963770@ qq.com)

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