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Dynamic Assessment of Tear Film Optical Quality in Dry Eye Using a Double-Pass Optical Quality Analysis System |
Yu Chen, Liqing Wei, Nannan Dong, Hengli Lian, Weihua Pan |
Eye Hospital, Wenzhou Medical University, Wenzhou 325027, China |
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Guide |
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Abstract Objective: To assess the relationship between optical quality dynamic change using a double-pass system
(OQAS-II) and tear breakup time (TBUT) in patients with dry eye disease. Methods: Thirty patients (60 eyes)
with dry eye disease in Hangzhou Xihu Eye Hospital were included in this serial case study from May 2018
to May 2019. All subjects underwent examinations as follows: TBUT under fluorescein staining, Shirmer
Ⅰ test (SⅠT) under topical anesthesia, and corneal fluorescein staining. The basic objective scattering index
(basic OSI), the average OSI under natural blinking within 20 s (mean OSI1), and the average OSI under
non-blinking within 20 s (mean OSI2) were recorded by the OQAS-II system. The differences between
mean OSI1 and basic OSI and mean OSI2 and basic OSI were recorded as ΔOSI1 and ΔOSI2, respectively.
Spearman correlation analysis was used to observe the correlation between ΔOSI1, ΔOSI2, basic OSI, mean
OSI1, mean OSI2, and BUT. Results: The average BUT was 0.93-7.05(2.56±1.02)s, the average of Shirmer Ⅰ was 11.33±7.93 mm/5 min, and corneal fluorescein staining was positive in 4 out of 60 eyes. The medians
of basic OSI, mean OSI1, mean OSI2, ΔOSI1, ΔOSI2 were 0.60(0.40, 1.28), 1.22(0.68, 2.22), 2.18(1.13,
2.85), 0.41(0.25, 1.01), 1.13(0.48, 2.30. Both ΔOSI1 and ΔOSI2 had anegative correlation with BUT
(r=-0.276, P=0.033; -0.305, P=0.018), no correlation between the remaining indexex. Conclusions: The
OQAS II system has the potential to be a useful method to evaluate the optical quality and tear-film dynamics
in patients with dry eye. When using OQAS-II to detect tear film stability, patients should be instructed to
blink as little as possible to provide more valuable results.
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Received: 27 April 2021
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Fund: |
Corresponding Authors:
Weihua Pan, Eye Hospital, Wenzhou Medical University, Wenzhou 325027, China
(Email: 995969194@qq.com)
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[1] |
南莉, 李丽华, 汤欣, 等. 泪膜稳定性与视觉质量. 中华眼科杂志, 2009, 45(2): 189-191. DOI: 10.3760/cma.j.issn.0412-4081.2009.02.022.
|
[2] |
Benedetto DA, Clinch TE, Laibson PR. In vivo observation oftear dynamics using fluorophotometry. Arch Ophthalmol, 1984,102(3): 410-412. DOI: 10.1001/archopht.1984.01040030328030.
|
[3] |
中华医学会眼科学分会角膜病学组. 干眼临床诊疗专家共识(2013 年). 中华眼科杂志, 2013, 49(1): 73-75. DOI: 10.3760/cma.j.issn.0412-4081.2013.01.020.
|
[4] |
Montés-Micó R. Role of the tear film in the optical quality ofthe human eye. J Cataract Refract Surg, 2007, 33(9): 1631-1635.DOI: 10.1016/j.jcrs.2007.06.019.
|
[5] |
Licznerski TJ, Kasprzak HT, Kowalik W. Application oftwyman-green interferometer for evaluation of in vivo breakup characteristic of the human tear film. J Biomed Opt, 1999, 4(1):176-182. DOI: 10.1117/1.429904.
|
[6] |
Tutt R, Bradley A, Begley C, et al. Optical and visual impact oftear break-up in human eyes. Invest Ophthalmol Vis Sci, 2000,41(13): 4117-4123.
|
[7] |
Thibos LN, Hong X. Clinical applications of the Shack-Hartmann aberrometer. Optom Vis Sci, 1999, 76(12): 817-825.DOI: 10.1097/00006324-199912000-00016.
|
[8] |
Martínez-Roda JA, Vilaseca M, Ondategui JC, et al. Opticalquality and intraocular scattering in a healthy young population.Clin Exp Optom, 2011, 94(2): 223-229. DOI: 10.1111/j.1444-0938.2010.00535.x.
|
[9] |
Díaz-Doutón F, Benito A, Pujol J, et al. Comparison of theretinal image quality with a Hartmann-Shack wavefront sensor and a double-pass instrument. Invest Ophthalmol Vis Sci, 2006,47(4): 1710-1716. DOI: 10.1167/iovs.05-1049.
|
[10] |
Benito A, Pérez GM, Mirabet S, et al. Objective opticalassessment of tear-film quality dynamics in normal and mildly symptomatic dry eyes. J Cataract Refract Surg, 2011, 37(8):1481-1487. DOI: 10.1016/j.jcrs.2011.03.036.
|
[11] |
苏远东, 梁庆丰, 王宁利, 等. 泪膜客观散射指数对干眼诊断价值的研究. 中华眼科杂志, 2017, 53(9): 668-674. DOI:10.3760/cma.j.issn.0412-4081.2017.09.007.
|
[12] |
孙龙格, 马忠旭, 马林, 等. 基于OQAS-Ⅱ视觉质量参数对轻中度干眼泪膜稳定性动态变化的评估. 中华实验眼科杂志, 2017, 35(4): 344-348. DOI: 10.3760/cma.j.issn.2095-0160.2017.04.012.
|
[13] |
Gouvea L, Waring GO 4th, Brundrett A, et al. Objectiveassessment of optical quality in dry eye disease using a doublepass imaging system. Clin Ophthalmol, 2019, 13: 1991-1996.DOI: 10.2147/OPTH.S211584.
|
[14] |
Tan CH, Labbé A, Liang Q, et al. Dynamic change of opticalquality in patients with dry eye disease. Invest Ophthalmol Vis Sci, 2015, 56(5): 2848-2854. DOI: 10.1167/iovs.14-15757.
|
[15] |
Diaz-Valle D, Arriola-Villalobos P, García-Vidal SE, et al. Effect of lubricating eyedrops on ocular light scattering as a measure of vision quality in patients with dry eye. J Cataract Refract Surg,2012, 38(7): 1192-1197. DOI: 10.1016/j.jcrs.2012.02.040.
|
[16] |
Montés-Micó R, Cerviño A, Ferrer-Blasco T, et al. Optical quality after instillation of eyedrops in dry-eye syndrome. J Cataract Refract Surg, 2010, 36(6): 935-940. DOI: 10.1016/j.jcrs.2009.12.044.
|
[17] |
Wu MF, Gao H, Zhao LJ, et al. Real dynamic assessment of tear film optical quality for monitoring and early prevention of dry eye. Medicine (Baltimore), 2020, 99(31): e21494. DOI:10.1097/MD.0000000000021494.
|
|
|
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