Abstract:Objective: To observe the prevalence of peripapillary retinoschisis (PPRS) in patients with primary open-angle glaucoma (POAG) by spectral domain optical coherence tomography (SD-OCT), classify PPRS according to the characteristics on OCT images, and explore the risk factors for different types of PPRS. Methods: A case series study was conducted. One hundred and one POAG patients who visited the glaucoma clinic of Peking University Third Hospital Eye Center from May 2021 to December 2022 were consecutively collected. The subjects underwent a complete ophthalmic examination, including best-corrected visual acuity, spherical equivalent, intraocular pressure, axial length, fundus photography, visual feld, and SD-OCT examination. The presence of PPRS was determined by SD-OCT radial scanning around the center of Bruch's membrane opening (BMO), and was divided into two subgroups (PPRS outside BMO and PPRS inside BMO) according to the relationship between the origin position of PPRS and the position of BMO. Meanwhile, the presence of vitreous traction and lamina cribrosa defect on scanning images were observed. The prevalence of PPRS was calculated, independent sample t-test and one-way analysis of variance, Kruskal-Wallis rank sum test, and Pearson Chi-square test was used to analyze data. The generalized estimation equation model was used to evaluate the potential risk factors of PPRS in multi-factor analysis. Results:Atotal of 84 cases (155 eyes) of POAG patients were included in this study. PPRS occurred in 32 cases (44 eyes), with a prevalence of 28.4%, including 19 PPRS outside BMO (12.3%) and 24 PPRS inside BMO (15.5%). Generalized estimating equation analysis showed that axial length (OR=1.46, P=0.008), vitreous traction (OR=2.69, P=0.034), and lamina cribrosa defect (OR=9.75, P<0.001) were independent risk factors for PPRS occurrence. While vitreous traction (OR=2.88, P=0.004) was an independent risk factor for the occurrence of PPRS outside BMO and lamina cribrosa defect (OR=25.91, P<0.001) was an independent risk factor for the occurrence of PPRS inside BMO. Conclusions: The occurrence of PPRS in POAG patients is mainly related to axial length, vitreous traction, and lamina cribrosa defect. Different risk factors are associated with PPRS in different subtypes, vitreous traction is more likely to cause PPRS outside BMO and lamina cribrosa defect is more likely to cause PPRS inside BMO.
代锦岳, 潘哲, 夏子尧, 等. 原发性开角型青光眼患者视盘旁视网膜劈裂的OCT分型及危险因素[J]. 中华眼视光学与视觉科学杂志, 2023, 25(9): 659-664.
Jinyue Dai, Zhe Pan, Ziyao Xia, et al. Classification and Risk Factors of Peripapillary Retinoschisis Based on OCT Images in Primary Open-Angle Glaucoma. Chinese Journal of Optometry Ophthalmology and Visual science, 2023, 25(9): 659-664. DOI: 10.3760/cma.j.cn115909-20230505-00142