巩膜细胞外基质在近视发生发展中的作用

doi:10.3760/cma.j.issn.1674-845X.2016.07.015

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摘要巩膜作为近视过程中的最后一层靶组织，其细胞外基质（ECM）的生物分子及生物力学特性在近视的形成和发展过程中发生重要变化。大量研究证实巩膜ECM的主动重塑是近视过程中的关键环节，近几年，探索巩膜ECM的重塑机制以及通过调控ECM的重塑过程来防治近视已成为屈光领域的研究热点。现就近年来有关巩膜ECM在近视发生发展中的作用做一综述。

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	田甜
	朱煌

关键词 ：巩膜, 细胞外基质, 近视

Abstract：The sclera is the final target tissue in myopia. The biological and biomechanical changes in the extracellular matrix (ECM) during the onset and development of myopia are significant. Numerous studies confirm that the initial remodeling of scleral ECM is a key part in the progression of myopia. Exploring the scleral ECM remodeling mechanisms as well as the regulation of the ECM remodeling process to control myopia has become a hot topic. Recent research related to the scleral ECM in myopia is reviewed in this paper.

Key words： Sclera Extracellular matrix Myopia

基金资助:上海市科委医学引导资助项目（10411966200）；上海市卫生局中医药科研基金（2014JP015A）

通讯作者: 朱煌，Email：drzhuhuang@163.com

引用本文:

田甜,朱煌. 巩膜细胞外基质在近视发生发展中的作用[J]. 中华眼视光学与视觉科学杂志, 2016, 18(7): 443-445. Tian Tian, Zhu Huang. Role of the scleral extracellular matrix in the development of myopia. Chinese Journal of Optometry Ophthalmology and Visual science, 2016, 18(7): 443-445. DOI: 10.3760/cma.j.issn.1674-845X.2016.07.015

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https://www.cjoovs.com/CN/10.3760/cma.j.issn.1674-845X.2016.07.015 或 https://www.cjoovs.com/CN/Y2016/V18/I7/443

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