Objective: To characterize the comprehensive treatment of retinoblastoma (RB) and investigate the related clinical factors. Methods: In this retrospective study, clinical datas were analyzed for 65 cases (92 eyes)of childhood RB that received comprehensive treatment, including chemotherapy, local treatment Oaser or
cryotherapy), and enucleation. Using t-test and Fisher's exact test to analyze the data. Results: The survival rate for the 65 cases was 92%. The eyeballs were preserved in 51% of the children. The rate of eyeball preservation in stage E group was significantly lower than the other four stage groups (P<O.OI). Children
in stage D group (18 cases) and stage E group (24 cases) were treated with chemotherapy combined with local therapy. The eyeballs were preserved in 11 cases in stage D groups and 4 cases in stage E groups.There were no significant differences in the clinical factors between eyeballs preserved or not children.
The patients in stage D and E groups were further divided into three groups according to the location of the tumors in the eye: it showed peripheral retina (including the mid- peripheral retina) group with higher rate of eyeball preservation than the posterior pole retina and the posterior pole retina+peripheral retina group(P=0.009, 0.021). Four of the 42 patients died, all with tumors located in the posterior pole retina (P=0.045 compared to the peripheral retina and to the posterior pole retina+peripheral retina). Conclusions: Compr-ehensive treatment improved the survival and eyeball preservation rate of children with RB. The survival
rates and eyeball preservation rates were closely related to the clinical stage.