Objective: To investigate the correlation of myopia severity with axial length (AL), central corneal thickness (CCT), intraocular pressure (IOP), corneal curvature (CC), and choroid thickness (CT) in children and adolescents. Methods: In this case series study, we selected myopic children and adolescents who were diagnosed in Shanxi Eye Hospital from March to December 2016. All of the children and adolescents were subjected to cycloplegic refraction, and CCT, IOP, AL, CC, and CT measurements. They were divided into three myopia groups, mild, moderate, and high, based on the spherical equivalent (SE). We then analyzed the correlation of the degree of myopia with CCT, IOP, AL, CC, and CT. Differences between groups were analyzed by one-way analysis of variance. Relationships between the relevant factors were analyzed by Pearson correlation analysis. Results: Eighty myopic children and adolescents (158 eyes), 7.9±2.4 years old, were included in this study. The SEs were -2.28±0.85 diopters (D), -4.43±0.82 D, and -8.51±1.50 D in the mild, moderate, and high myopia groups respectively. The ALs were 24.0±0.7 mm, 25.0±0.6 mm, and 26.6±1.5 mm in the respective myopia groups (F=55.03, P<0.001). The CTs were 280±82 μm, 207±63 μm,and 184±72 μm in the respective myopia groups (F=12.64, P<0.001). There were no significant differences for CCT, IOP, or CC among the different groups. CT was significantly correlated to myopia (r =-0.590,P<0.001), AL (r =-0.567, P<0.001), and CCT (r =-0.300, P=0.007). Conclusions: There is a positive correlation between the progression of myopia and the increase in AL. There is a negative correlation between
myopia and the foveal CT. Finally, the relationship between myopia and CCT, IOP, and CC is not clear.
张立华,董慧,贾丁. 青少年儿童近视屈光度与眼球生物学屈光参数及中心凹下脉络膜厚度的关系[J]. 中华眼视光学与视觉科学杂志, 2018, 20(4): 222-226.
Lihua Zhang,Hui Dong,Ding Jia. Correlation of Myopia with Ocular Biometric Rerfractive Parameters and Choroid Thickness in Children and Adolescents. Chinese Journal of Optometry Ophthalmology and Visual science, 2018, 20(4): 222-226. DOI: 10.3760/cma.j.issn.1674-845X.2018.04.006
Sun J, Zhou J, Zhao P, et al. High prevalence of myopia and high myopia in 5 060 Chinese university students in Shanghai.Invest Ophthalmol Vis Sci, 2012, 53(12): 7504-7509. DOI:
10
1167/iovs.11-8343.
[2]
Wong YL, Saw SM. Epidemiology of pathologic myopia in Asia and worldwide. Asia Pac J Ophthalmol (Phila), 2016, 5(6): 394-402. DOI: 10.1097/APO.0000000000000234.
10
1167/iovs.11-8343.
[2]
Wong YL, Saw SM. Epidemiology of pathologic myopia in Asia and worldwide. Asia Pac J Ophthalmol (Phila), 2016, 5(6): 394-402. DOI: 10.1097/APO.0000000000000234.
[3]
Zhu H, Wang FH, Sun XD.Anti-vascular endothelial growth factor: the future treatment of choroidal neovascularization in pathologic myopia? Chin Med J (Engl), 2013, 126(8): 1578-
Zhu H, Wang FH, Sun XD.Anti-vascular endothelial growth factor: the future treatment of choroidal neovascularization in pathologic myopia? Chin Med J (Engl), 2013, 126(8): 1578-
Saw SM, Chua WH, Hong CY, et al. Height and its relationship to refraction and biometry parameters in Singapore Chinese children. Invest Ophthalmol Vis Sci, 2002, 43(5): 1408-1413.
Saw SM, Chua WH, Hong CY, et al. Height and its relationship to refraction and biometry parameters in Singapore Chinese children. Invest Ophthalmol Vis Sci, 2002, 43(5): 1408-1413.
Garcia-Medina M, Garcia-Medina JJ, Garrido-Fernandezp, et al.Central corneal thickness, intraocular pressure, and degree of myopia in an adult myopic population aged 20 to 40 years in southeast. Spain: determination and relationships. Chin Ophthalmol, 2011, 5: 249-258. DOI: 10.2147/OPTH.S16594.
Garcia-Medina M, Garcia-Medina JJ, Garrido-Fernandezp, et al.Central corneal thickness, intraocular pressure, and degree of myopia in an adult myopic population aged 20 to 40 years in southeast. Spain: determination and relationships. Chin Ophthalmol, 2011, 5: 249-258. DOI: 10.2147/OPTH.S16594.
Lim LS, Gazzard G, Low YL, et al. Dietary factors, myopia, and axial dimensions in children. Ophthalmology, 2010, 117(5):993-997.e4. DOI: 10.1016/j.ophtha.2009.10.003.
[14]
Chia A, Lu QS, Tan D. Five-Year Clinical Trial on Atropine for the Treatment of Myopia 2: Myopia Control with Atropine 0.01% Eyedrops.Ophthalmology, 2016, 123(2): 391-399. DOI:
Lim LS, Gazzard G, Low YL, et al. Dietary factors, myopia, and axial dimensions in children. Ophthalmology, 2010, 117(5):993-997.e4. DOI: 10.1016/j.ophtha.2009.10.003.
[14]
Chia A, Lu QS, Tan D. Five-Year Clinical Trial on Atropine for the Treatment of Myopia 2: Myopia Control with Atropine 0.01% Eyedrops.Ophthalmology, 2016, 123(2): 391-399. DOI:
10
1016/j.ophtha.2015.07.004.
[15]
Fam HB, How AC, Baskaran M, et al. Central corneal thickness and its relationship to myopia in Chinese adults.Br J Ophthalmol, 2006, 90(12): 1451-1453. DOI: 10.1136/
10
1016/j.ophtha.2015.07.004.
[15]
Fam HB, How AC, Baskaran M, et al. Central corneal thickness and its relationship to myopia in Chinese adults.Br J Ophthalmol, 2006, 90(12): 1451-1453. DOI: 10.1136/
Tomlison A, Phillips CL. Applanation tension and axial length of the eyeball. Br J Ophthalmol, 1970, 54(8): 548-53. DOI:10.1136/bjo.54.8.548.
[21]
Nomura H, Ando F, Niino N, et al. The relationship between intraocular pressure and refractive error adjusting for age and central corneal thickness. Ophthalmic Physiol Opt, 2004, 24(1):41-45. DOI: 10.1046/j.1475-1313.2003.00158.x.
[22]
Lee AJ, Saw SM, Gazzard G, et al. Intraocular pressure associations with refractive error and axial length in children. Br J Ophthalmol, 2004, 88(1): 5-7. DOI: 10.1136/bjo.88.1.5.
[23]
Chan WM, Ohji M, Lai TY, et al. Choroidal neovascularisation in pathological myopia: an update in management. Br J Ophthalmol, 2005, 89(11): 1522-1528. DOI: 10.1136/
Tomlison A, Phillips CL. Applanation tension and axial length of the eyeball. Br J Ophthalmol, 1970, 54(8): 548-53. DOI:10.1136/bjo.54.8.548.
[21]
Nomura H, Ando F, Niino N, et al. The relationship between intraocular pressure and refractive error adjusting for age and central corneal thickness. Ophthalmic Physiol Opt, 2004, 24(1):41-45. DOI: 10.1046/j.1475-1313.2003.00158.x.
[22]
Lee AJ, Saw SM, Gazzard G, et al. Intraocular pressure associations with refractive error and axial length in children. Br J Ophthalmol, 2004, 88(1): 5-7. DOI: 10.1136/bjo.88.1.5.
[23]
Chan WM, Ohji M, Lai TY, et al. Choroidal neovascularisation in pathological myopia: an update in management. Br J Ophthalmol, 2005, 89(11): 1522-1528. DOI: 10.1136/