Objective To investigate the effect on cornea topographical characteristcs of thyroid-associated ophthalmology （TAO） disease. Methods In this prospective case control study， 46 eyes of 24 patients diagnosed with the inactive TAO were recruited as study group， 30（30 eyes） age and sex matched healthy volunteers were as control group. TAO was diagnosed based on the basis of criteria of Eruopean Group Grave′s Orbitopathy and the activity was decided by the Clinical Activity Score （CAS）. Cornea topographical characteristics of each group was obtained by using Pentacam system via one experienced doctor， including the index surface virance （ISV）， index of vertical asymmetry （IVA）， index of highest asymmetry （IHA）， index of highest decentration （IHD） and minimal sagittal curvature （Rim）， central cornea thickness （CCT）， refractive power and astigmatism of front and back cornea. Data were analyzed using independent to test and rank sum test. Results ISV in TAO was 21.00（10-71）， higher than control group [14.0（10-34）] （Z=1.31， P＜0.01）； IVA was 0.180（0.07-0.70）， higher than control group [0.100（0.50-0.37）]（Z=1.08， P＜0.01）； IHA was 5.950（0.0-28.7）， higher than control group [1.65（0.2-13.9）]（Z=84.34， P＜0.01）； IHD was 0.020±0.015， higher than control group （0.010±0.004）（t=5.67， P＜0.01）； Rim was 7.43±0.30 mm， lower than control group （7.62±0.26 mm）（t=-2.505， P＜0.01）； CCT was 523.74±26.00 μm， lower than control group （546.25±28.84 μm）（t=3.230， P＜0.01）； K1 of front cornea was 43.58±1.18 D， higher than control group （42.86±1.43 D）， （t=2.123， P＜0.05）； K1 of back cornea was -6.20 D（-7.2--5.7 D）， higher than control group [-6.10 D（-6.6--5.7 D）]（Z=101.4， P＜0.01）. There was no siginificant difference in K2， astigmatism between study and control group. Conclusion The TAO may lead to the decrease of cornea symmetry and have an effect on refractive power of cornea.
佘相均,洪明胜,余心洁,陈捷灵,张俐娜,盛文,毛剑波,陈峰,沈丽君. 甲状腺相关眼病对角膜对称性及角膜屈光力的影响[J]. 中华眼视光学与视觉科学杂志, 2013, 15(11): 675-679.
HE Xiang-jun,HONG Ming-sheng,YU Xin-jie,CHEN Jie-ling,ZHANG Li-na,SHENG Wen,MAO Jian-bo,CHEN Feng,SHEN Li-jun. A clinical research of the cornea symmetry and refractive power of thyroid-associated ophthalmology disease. Chinese Journal of Optometry Ophthalmology and Visual Science, 2013, 15(11): 675-679. DOI: 10.3760/cma.j.issn.1674-845X.2013.11.009
Quisling S， Sjoberg S， Zimmerman B， et al. Comparison of Pentacam and Orbscan IIz on posteriorcurvature topography measurements in keratoconus eyes. Ophthalmology，2006，113：1629-1632.
[7]
Barkana Y， Gerber Y， Elbaz U， et al. Central corneal thickness measurement with the Pentacam Scheimpflug system， optical low-coherence reflectometry pachymeter， and ultrasound pachymetry. J Cataract Refract Surg，2005，31：1729-1735.
[8]
Mombaerts I， Vandelanotte S， Koornneef L. Corneal astigmatism in Graves′ ophthalmopathy. Eye （Lond），2006，20：440-446.
[9]
Kwitko S， Feldon S， McDonnell PJ. Corneal topographic changes following strabismus surgery in Graves′ disease. Cornea，1992， 11：36-40.
[10]
Wilson G， Bell C， Chotai S. The effect of lifting the lids on corneal astigmatism. Am J Optom Physiol Opt，1982，59：670-674.
[11]
Cuttone JM， Durso F， Miller M， et al. The relationship between soft tissue anomalies around the orbit and globe and astigmatic refractive errors： a preliminary report. J Pediatr Ophthalmol Strabismus，1980，17：29-36.
[12]
Terai N， Raiskup F， Haustein M， et al. Identification of biomechanical properties of the cornea： the ocular response analyzer. Curr Eye Res，2012，37：553-562.
[14]
Yazici AT， Kara N， Yüksel K， et al. The biomechanical properties of the cornea in patients with systemic lupus erythematosus. Eye （Lond），2011，25：1005-1009.
[15]
Konuk O， Aktas Z， Aksoy S， et al. Hyperthyroidism and severity of orbital disease do not change the central corneal thickness in Graves′ ophthalmopathy. Eur J Ophthalmol，2008， 18：125-127.
[16]
Prabhakar BS， Bahn RS， Smith TJ. Current perspective on the pathogenesis of Graves′ disease and ophthalmopathy. Endocr Rev，2003，24：802-835.
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