Abstract:Objective: To investigate the influence of an implantable collamer lens with CentraFLOW (ICL V4c) on total wave-front aberrations, corneal wave-front aberrations and intraocular wave-front aberrations in moderate and high myopia patients after the implantation. Methods: This was a prospective study of 88 eyes of 44 moderate and high myopia patients who received ICL V4c implants in Nanchang Aier Hospital during May 2019 to December 2020. The Corneal refractive analyzer was used to measure total wave-front aberrations, corneal wave-front aberrations and intraocular wave-front aberrations at 3 mm, 4 mm, and 6 mm pupil diameters preoperatively and at 3 months postoperatively. A paired t-test was used to analyze the changes in total, corneal, and intraocular wave-front aberrations from preoperative measurements to measurements at 3 months postoperatively. Measurements included total, Tilt(S1), higherorder, coma, trefoil, and spherical aberrations. Results: At 3 months postoperatively, the safety index and efficacy index of the surgery were 1.15±0.12 and 1.11±0.12, respectively. At 3, 4, and 6 mm pupil diameters, the postoperative total aberrations were 0.34±0.14, 0.57±0.23, and 1.81±0.83 μm, respectively, and total intraocular aberrations were 0.34±0.11, 0.52±0.16, and 1.74±0.68 μm, respectively, which were significantly reduced compared to preoperative aberrations (total aberrations: t=14.67, P<0.001; t=16.68, P<0.001; t=14.35, P<0.001; total intraocular aberrations: t=15.41, P<0.001; t=13.89, P<0.001; t=13.21, P<0.001), At a 6 mm pupil diameter, the postoperative total higher-order aberrations, coma, and spherical aberrations had increased significantly compared to preoperative eyes (t=-3.62, P=0.001; t=-2.84, P=0.008; t=-2.94, P=0.006). The postoperative intraocular higher-order aberrations and coma had significantly increased compared to preoperative eyes (t=-2.65, P=0.013; t=-3.02, P=0.005). Other aberrations did not show significant changes compared to preoperative eyes. Conclusion: ICL V4c implantation is safe and effective for correcting moderate and high myopia. It can reduce total aberrations and total intraocular aberrations, and there is no significant change in corneal aberrations.
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