Objective To investigate the relationship between central corneal thickness （CCT） measured by optical coherence tomography （OCT） and age， spherical equivalent（SE）， axial length， gender， and right vs. left eye in myopic juveniles. Methods This was a cross-sectional study. One hundred and forty-three juveniles （age range， 7~18 years） underwent ophthalmic examination. CCT was measured by a Stratus OCT on one randomly selected eye of each subject. Axial length was measured by A-scan ultrasound. SE was measured after cycloplegia. The effects of several factors （age， SE， axial length， gender， and right vs. left eye） on CCT were investigated in univariate regression analyses and multivariate stepwise regression analyses. Results The mean CCT was 549.3±35.7 μm . In univariate regression analysis， no correlation was found between CCT and age （r=0.065， P>0.05）， gender （r=0.059， P>0.05）， refractive status （r=0.125， P>0.05）， or axial length （r=0.146， P>0.05）. There was a significant positive correlation between CCT and SE （r=0.250， P<0.01）. The regression equation was ■=561.458+4.514X （F=9.417， P<0.01）. In multivariate stepwise regression analysis， there was also a significant positive correlation between CCT and SE （r=0.247， P<0.01）. The regression equation was ■=561.096+4.465X （F=8.813， P<0.01）. And the following parameters were not significantly associated with CCT： age， gender， right vs. left eye， or axial length. Conclusion The Stratus OCT is a good instrument to measure children′s CCT. Among Chinese myopic juveniles， CCT did not correlate with axial length， age， gender or right vs. left eye， but showed a direct correlation with SE.
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