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A study of contrast sensitivity in hypertension disorders caused by a complication of pregnancy and the resulting changes in the fundus |
Wang Zhixue,Wang Wenying,Han Fengmei,Sun Yu |
Department of Ophthalmology, the Cangzhou Central Hospital, Cangzhou 061000, China |
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Abstract Objective To study contrast sensitivity (CS) in hypertensive disorders caused by a complication of pregnancy and the changes in the fundus during the follow-up period. Methods A prospective cohort study was applied to the research, ninety-eight patients with hypertensive disorders as a complication of pregnancy(the patient group) agreed to undergo eye examinations that included visual acuity, fundus examinations, and CS evaluations. Patients were followed up for 6 months and visual acuity and CS changes were monitored. Fifty pregnant women were selected as a control group during the same period. The corrected visual acuity for the two groups and the CS at each spatial frequency were compared with two independent sample t-tests. The CS of each spatial frequency in the three trimesters with retinopathy and during the follow-up was compared with a Kruskal-Wallis rank sum test. After multiple group analysis, a comparison between pairs of groups was analyzed with a Satterthwaite approximation test. Results The corrected visual acuities of patients with hypertensive disorders as a complication of pregnancy were lower than those for the normal control group at the first visit and after the six-month follow-up period (t=13.67, 2.27, P<0.05). Retinal disease worsened during retinopathy in the three trimesters and the CS values for each spatial frequency decreased (χ²=93.35, 88.28, 89.73, 102.48, 102.26, P<0.01). During the six-month follow-up period, CS spatial frequencies gradually approached normal and the 6 c/d frequency was close to that of the normal control group (P>0.05), but the other spatial frequencies were reduced (t=2.74, -5.42, -8.67, -4.60, P<0.01). The recovery of a CS for 1.5 c/d spatial frequency was the fastest, and recovery for 12 c/d was the slowest. There were no significant differences in spatial frequency CS between the two kinds of delivery methods used at birth (P>0.05). Conclusion Fundus changes in patients with hypertensive disorders as a complication of pregnancy and the decrease in CS are both more serious than for normal patients. CS with the low spatial frequency had the fastest recovery and a high spatial frequency was the slowest to recover. The two kinds of delivery methods for birth have no effect on the recovery of CS. CS is a better indicator than visual acuity to reflect the function of the retina in patients with hypertensive disorders as a complication of pregnancy.
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Received: 15 October 2015
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Corresponding Authors:
Wang Zhixue, Email: wangzhixue5@163.com
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