Objective To compare early visual outcomes of SmartPulse Technology (SPT)-assisted transepithelial photorefractive keratectomy (TPRK) or femtosecond laser-assisted laser in situ keratomileusis (FS-LASIK) with that of traditional TPRK/FS-LASIK. Methods This was a retrospective comparative study of two main groups, a surface surgery group and a stromal surgery group. The surface surgery group included two subgroups: an SPT-TPRK group consisting of 36 eyes of 19 patients and a TPRK group consisting of 40 eyes of 21 patients. All patients were followed up on the 3rd day, 10th day, 1st month and 3rd month after surgery and uncorrected visual acuity (UCVA) was measured and recorded. The stromal surgery group included two subgroups: an SPT-FS-LASIK group consisting of 49 eyes of 25 patients and a FS-LASIK group consisting of 48 eyes of 24 patients. All patients were followed up on the 1st day, 10th day, 1st month, and 3rd month after surgery, and UCVA was measured and recorded. Topography was performed before surgery and on the 1st month and 3rd month after surgery in all patients. Statistical analysis included repeated measures ANOVA, ?字２ test and independent t-test. Results There were no significant differences between the SPT-TPRK group and TPRK group in age, spherical equivalent, best corrected visual acuity or central corneal thickness before surgery, nor were there any significant differences between the SPT-FＳ-LASIK group and FＳ-LASIK group in the pre-operative examinations. There were no significant differences in post-operative UCVA between the TPRK and SPT-TPRK groups at any time point after surgery. However, there was a significant difference in UCVA between the SPT-FＳ-LASIK group and FＳ-LASIK group (F=12.067, P<0.01) on the 1st day and 10th day (P<0.05) after surgery with better acuity results in the SPT-FS-LASIK group. But there was no significant difference in post-operative visual outcomes between these two groups on the 1st and 3rd months. The surface regularity index (SRI) of the SPT-FS-LASIK group on the 1st month was significantly lower than that of the FS-LASIK group (t=2.95, P<0.01). Conclusion SPT-FS-LASIK tends to provide better UCVA than traditional FS-LASIK during the early days after surgery.