非诺贝特治疗糖尿病视网膜病变的临床研究进展

doi:10.3760/cma.j.issn.1674-845X.2013.08.016

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Abstract

Fenofibrate， which is a peroxisome proliferator-activated receptor α （PPARα） agonist， has beneficial effects on lipid profiles that include lowering triglycerides and increasing high-density lipoprotein cholesterol， and reducing coronary vascular events in large clinical trials. Results from recent clinical trials suggest a role for fenofibrate in reducing the progression and/or inducing regression in mild-to-moderate nonproliferative diabetic retinopathy （DR）. The role of fenofibrate in the pathogenesis of diabetic retinopathy is associated with its anti-inflammatory properties. The effect and mechanisms of fenofibrate in the pathogenesis of diabetic retinopathy are reviewed in this article.

Key words： Diabetic retinopathy Fenofibrate Diabetes mellitus

Received: 20 January 2013

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https://www.cjoovs.com/EN/10.3760/cma.j.issn.1674-845X.2013.08.016 OR https://www.cjoovs.com/EN/Y2013/V15/I8/510

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