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Structural Imaging of Benign conjunctival Proliferative Diseases Using Optical coherence Tomography |
Fengping Zhao,Chixin Du,Sijie Cai |
Department of Ophthalmology, the First Affiliated Hospital, College of Medicine Zhejiang University,Hangzhou 310000, China
Department of Ophthalmology, the Forth Affiliated Hospital, College of Medicine Zhejiang University,Jinhua 322000, China
Department of Ophthalmology, Yiwu Traditional China Medicine Hospital, Jinhua 322000, China |
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Abstract Objective: To use anterior segment optical coherence tomography (AS-OCT) for structural imaging and accurate measurements of pinguecula and pterygium in order to understand the structural features of these lesions. Methods: This study was a prospective parallel control study. Lateral bulbar conjunctiva of 25 cases (30 eyes) that included pinguecula (10 eyes of 8 cases), pterygium (10 eyes of 9 cases), and normal eyes (10 eyes of 8 cases), were enrolled from the Department of Ophthalmology of the Fourth Affiliated Hospital of Zhejiang Medical University from January to April 2018. The anterior segment module of an Optovue optical coherence tomography angiography (OCTA) was used for measurements. The thickness of the bulbar conjunctiva epithelium and propria tissues at sites at a distance of 0.0 mm, 0.5 mm, 1.0 mm,1.5 mm, 2.0 mm and 2.5 mm from the scleral process were stratified within the 2.5 mm range, were measured, compared and further analyzed. The data were described by means of mean ± standard deviation.Repeated measurement analysis of variance was used for comparison of each point in the group, one-way analysis of variance was used for comparison between groups. results: Compared with normal eyes and pinguecula eyes, pterygium showed thickened epithelium in 0.5 mm point (P<0.05). In the 2.5 mm range on the nasal side, pterygium and pinguecula showed thickened subepithelium tissues (P<0.05), especially for pterygium, compared to normal eye tissue. conclusions: AS-OCT can image microstructures in benign conjunctival proliferative diseases, resulting in accurate quantitative diagnosis and evaluation. The thickness of subepithelium tissues increases in pinguecula and pterygium.
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Received: 24 April 2018
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Fund: Application Research on Public Welfare Technology of Zhejiang Province (2016C33143); Key Project of Natural Science Foundation of Zhejiang Province (LZ15F050002) |
Corresponding Authors:
Chixin Du, Department of Ophthalmology, the Forth Affiliated Hospital, College of Medicine Zhejiang University, Jinhua 322000, China (Email: duchixin@zju.edu.cn)
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[1] |
Alfonso F, Sandoval J, Cárdenas A, et al. Optical coherence tomography: from research to clinical application. Minerva Med, 2012, 103(6): 441-464.
|
[1] |
Alfonso F, Sandoval J, Cárdenas A, et al. Optical coherence tomography: from research to clinical application. Minerva Med, 2012, 103(6): 441-464.
|
[2] |
Sarunic MV, Asrani S, Izatt JA. Imaging the ocular anterior segment with real-time, full-range fourier-domain optical coherence tomography. Arch Ophthalmol, 2008, 126(4): 537-
|
54 |
2. DOI: 10.1001/archopht.126.4.537.
|
[3] |
Goldsmith JA, Li Y, Chalita MR, et al. Anterior chamber width measurement by high speed optical coherence tomography.Ophthalmology, 2005, 112(2): 238-244. DOI: 10.1016/
|
[2] |
Sarunic MV, Asrani S, Izatt JA. Imaging the ocular anterior segment with real-time, full-range fourier-domain optical coherence tomography. Arch Ophthalmol, 2008, 126(4): 537-
|
54 |
2. DOI: 10.1001/archopht.126.4.537.
|
[3] |
Goldsmith JA, Li Y, Chalita MR, et al. Anterior chamber width measurement by high speed optical coherence tomography.Ophthalmology, 2005, 112(2): 238-244. DOI: 10.1016/
|
|
j.ophtha.2004.09.019.
|
|
j.ophtha.2004.09.019.
|
[4] |
Marion KM, Dastiridou A, Niemeyer M, et al. Anterior chamber angle morphometry measurement changes to ambient illumination scaling in visante time domain optical coherence
|
|
tomography. Curr eye res, 2017, 42(3): 386-393. DOI:10.1080/02713683.2016.1190847.
|
[5] |
Ramos JLB, Li Y, Huang D. Clinical and research applications of anterior segment optical coherence tomography-a review.Clin Exp Ophthalmol, 2009, 37(1): 81-89. DOI: 10.1111/j.1442-9071.2008.01823.x.
|
[6] |
Han SB, Liu YC, Noriega KM, et al. Applications of anterior segment optical coherence tomography in cornea and ocular surface diseases. J Ophthalmol, 2016, 2016: 4971572. DOI:10.1155/2016/4971572.
|
[7] |
董晶, 高晓唯, 胡裕坤, 等. Pentacam与前节OCT测量有晶状体眼后房型人工晶状体植入术后拱高的比较. 中华眼视光学与视觉科学杂志, 2016, 18(12): 724-728. DOI: 10.3760/cma.
|
[4] |
Marion KM, Dastiridou A, Niemeyer M, et al. Anterior chamber angle morphometry measurement changes to ambient illumination scaling in visante time domain optical coherence
|
|
tomography. Curr eye res, 2017, 42(3): 386-393. DOI:10.1080/02713683.2016.1190847.
|
[5] |
Ramos JLB, Li Y, Huang D. Clinical and research applications of anterior segment optical coherence tomography-a review.Clin Exp Ophthalmol, 2009, 37(1): 81-89. DOI: 10.1111/j.1442-9071.2008.01823.x.
|
[6] |
Han SB, Liu YC, Noriega KM, et al. Applications of anterior segment optical coherence tomography in cornea and ocular surface diseases. J Ophthalmol, 2016, 2016: 4971572. DOI:10.1155/2016/4971572.
|
[7] |
董晶, 高晓唯, 胡裕坤, 等. Pentacam与前节OCT测量有晶状体眼后房型人工晶状体植入术后拱高的比较. 中华眼视光学与视觉科学杂志, 2016, 18(12): 724-728. DOI: 10.3760/cma.
|
|
j.issn.1674-845X.2016.12.005.
|
|
j.issn.1674-845X.2016.12.005.
|
[8] |
Kieval JZ, Karp CL, Abou SM, et al. Ultra-high resolution optical coherence tomography for differentiation of ocular surface squamous neoplasia and pterygia. Ophthalmology, 2012,
|
11 |
9(3): 481-486. DOI: 10.1016/j.ophtha.2011.08.028.
|
[9] |
Seager FE, Wang J, Arora KS, et al. The effect of scleral spur identification methods on structural measurements by anterior segment optical coherence tomography. J Glaucoma, 2014,23(1): e29-38. DOI: 10.1097/IJG.0b013e31829e55ae.
|
[8] |
Kieval JZ, Karp CL, Abou SM, et al. Ultra-high resolution optical coherence tomography for differentiation of ocular surface squamous neoplasia and pterygia. Ophthalmology, 2012,
|
11 |
9(3): 481-486. DOI: 10.1016/j.ophtha.2011.08.028.
|
[9] |
Seager FE, Wang J, Arora KS, et al. The effect of scleral spur identification methods on structural measurements by anterior segment optical coherence tomography. J Glaucoma, 2014,23(1): e29-38. DOI: 10.1097/IJG.0b013e31829e55ae.
|
[10] |
李凤鸣. 中华眼科学. 3版. 北京: 人民卫生出版社, 2014: 135.
|
[11] |
Malozhen SA, Trufanov SV, Krakhmaleva DA. Pterygium:Etiology, pathogenesis, treatment. Vestn Oftalmol, 2017, 133(5):76-83. DOI: 10.17116/oftalma2017133576-83.
|
[12] |
Feng Y, Simpson TL. Corneal, limbal, and conjunctival epithelial thickness from optical coherence tomography. Optom Vis Sci,2008, 85(9): E880-883. DOI: 10.1097/OPX.0b013e318185272d.
|
[13] |
Zhang X, Li Q, Xiang M, et al. Bulbar conjunctival thickness measurements with optical coherence tomography in healthy Chinese subjects. Invest Ophthalmol Vis Sci, 2013, 54(7): 4705-4709. DOI: 10.1167/iovs.12-11003.
|
[14] |
Read SA, Alonso-Caneiro D, Free KA, et al. Diurnal variation of anterior scleral and conjunctival thickness. Ophthalmic Physiol Opt, 2016, 36(3): 279-289. DOI: 10.1111/opo.12288.
|
[10] |
李凤鸣. 中华眼科学. 3版. 北京: 人民卫生出版社, 2014: 135.
|
[11] |
Malozhen SA, Trufanov SV, Krakhmaleva DA. Pterygium:Etiology, pathogenesis, treatment. Vestn Oftalmol, 2017, 133(5):76-83. DOI: 10.17116/oftalma2017133576-83.
|
[12] |
Feng Y, Simpson TL. Corneal, limbal, and conjunctival epithelial thickness from optical coherence tomography. Optom Vis Sci,2008, 85(9): E880-883. DOI: 10.1097/OPX.0b013e318185272d.
|
[13] |
Zhang X, Li Q, Xiang M, et al. Bulbar conjunctival thickness measurements with optical coherence tomography in healthy Chinese subjects. Invest Ophthalmol Vis Sci, 2013, 54(7): 4705-4709. DOI: 10.1167/iovs.12-11003.
|
[14] |
Read SA, Alonso-Caneiro D, Free KA, et al. Diurnal variation of anterior scleral and conjunctival thickness. Ophthalmic Physiol Opt, 2016, 36(3): 279-289. DOI: 10.1111/opo.12288.
|
|
|
|