Objective: To demonstrate the changes in posterior corneal curvature after femtosecond laser LASIK with different corneal hysteresis (CH) measurements in high myopia. Methods: This was a prospective study. One hundred and three patients (206 eyes) were collected from January 2014 to January 2015 at the First Affiliated Hospital of Harbin Medical University, and were divided into two groups according to CH: group A (CH<9.6) and group B (CH>9.6). The changes in posterior corneal curvature were obtained by an analysis at pre-operation and postoperative 1 month, 3 months, 6 months and 12 months. Data were analyzed with t-test and repeated measure ANOVA. Results: One hundred patients (200 eyes) finished the study at last. There were 54 patients in group A and 46 patients in group B. The posterior corneal curvatures of group A at postoperative 1 month, 3 months, 6 months and 12 months were 6.37±0.09 D, 6.44±0.09 D,6.43±0.09 D, and 6.43±0.09 D, respectively. The differences were statistically significant between pre-operation and the different postoperative times (F=104.11, P<0.001). There was a statistically significant difference between 1 month and 3 months (P<0.05), but no significant differences between 3 and 6 months or 6 and 12 months. The posterior corneal curvatures of group B at postoperative 1, 3, 6 and 12 months were 6.29±0.08 D, 6.36±0.09 D, 6.37±0.09 D, and 6.37±0.09 D, respectively. There were statistically significant differences between pre-operation and all of the different postoperative times (F=138.05,P<0.001). There was a statistically significant difference between 1 month and 3 months (P<0.05), but no significant difference between 3 months and 6 months or 6 and 12 months. There were statistically significant differences between group A and group B after surgery in the values of posterior corneal curvature at different time points (t=4.78, 4.39, 3.56, 3.17, P<0.05). Conclusions: Presurgical corneal hysteresis influences the effect of femtosecond laser LASIK on posterior corneal curvature. CH can be set as the index to clinically evaluate the safety of femtosecond laser LASIK.