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Repeatability and Agreement in Measuring Adolescents and Children’s Corneal thickness with Corvis st and ss-1000 swept-source Optical Coherence tomography |
Yan Lian,Yali Xu,Xueli Shao,Jun Jiang,Xinjie Mao,Wanqing Jin |
Eye Hospital, Wenzhou Medical University, Optometry School of Wenzhou Medical University, Wenzhou325027, China |
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Abstract Objective: To assess the repeatability of central corneal thickness (CCT) measurements in adolescents and children using the Corvis ST and to examine the agreement between Corvis ST and SS-1000 swept-source optical coherence tomography (SS-1000 OCT). Methods: In this case series study, 44 children who visited the Eye Hospital, Wenzhou Medical University, from January to April of 2015 were enrolled. The age range was between 8 to 14 years old. The subjects were myopic without any other disease. CCT measurements were obtained first with the Corvis ST and then with SS-1000 OCT. The data of the right eyes was analyzed. An intraclass correlation coefficient (ICC), Bland-Altman plots and repeated-measures analysis of variance (ANOVA) were used to assess the repeatability of the Corvis ST. Paired t-tests and Bland-Altman plots were used to compare the agreement between the two devices. Results: The mean ICC of the Corvis ST was 0.987. Bland-Altman plots showed agreement between any two of three measurements (95% limits of agreement was -15.6~16.2 μm, -15.7~13.4 μm, -16.0~13.1 μm, respectively). No statistical significance was found with repeated-measures ANOVA. The mean values of CCT acquired from Corvis ST and SS-1000 OCT were 553±29 μm and 540±28 μm. CCT measured by the Corvis ST was 13 μm thicker than that by SS-1000 OCT (t=-6.037, P<0.001). The 95% limits of agreement were -15.2~41.6 μm for these two devices. Conclusions: The Corvis ST shows excellent repeatability of CCT measurements in healthy children’s eyes. Though there is a good agreement between the two devices for CCT measurements,there are significant differences between them. The measurements acquired by Corvis ST should not be directly interchangeable with SS-1000 OCT measurements in clinical practice.
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Received: 31 January 2018
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Fund: Zhejiang Medical Science and Technology Project (2018KY542); Wenzhou Commonweal Technology Project (Y20150253); Eye Hospital of Wenzhou Medical University Innovation Grant(YNCX201402) |
Corresponding Authors:
Wanqing Jin, Eye Hospital, Wenzhou Medical University, Optometry School of Wenzhou Medical University, Wenzhou 325027, China (Email: wcyjqw@163.com)
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