FLEx与SMILE术后早期干眼指标对比

doi:10.3760/cma.j.issn.1674-845X.2018.12.005

Abstract
Figure/Table
References (20)
Related Citation (15)

Download: PDF (724 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract

Objective: To compare early changes in dry eye after femtosecond lenticule extraction (FLEx) and small incision lenticule extraction (SMILE). Methods: Twenty-eight subjects (56 eyes) underwent FLEx and 33 subjects (66 eyes) underwent SMILE in this prospective non-randomized study at the Refractive Center of Hainan Eye Hospital and Key Laboratory of Ophthalmology from February to October 2014. Ocular surface disease index (OSDI), Schirmer Ⅰ test (SⅠT), noninvasive tear breakup time (NIBUT), and tear meniscus height (TMH) were evaluated at 1 day, 1 week and 1 month after surgery but corneal fluorescein staining (FL) was measured only at 1 week and 1 month postoperatively in all patients. Concentrations of interleukin-1α (IL-1α) and tumor necrosis factor-α (TNF-α) in collected tears were assessed by multiplex antibody microarray at 1 day, 1 week and 1 month after surgery in both groups. Data were analyzed using repented measured ANOVA. Results: The NIBUT of the FLEx group was shorter than that of the SMILE group (P=0.029) and the FL scores of FLEx were worse than that of the SMILE group (P=0.037) at 1 week after surgery. OSDI scores of both groups were better than baseline levels (all P<0.001). There were no significant changes found in OSDI, SⅠT and TMH between the FLEx and SMILE groups. Higher tear concentrations of IL-1α were found in the FLEx group than that in the SMILE group (P=0.019). There was no significant difference in tear concentrations of TNF-α between the two groups. Conclusions: The early dry eye in the SMILE group was milder than in the FLEx group.

Key words： femtosecond lenticule extraction small incision lenticule extraction dry eye

Received: 06 June 2018

Fund:

Natural Science Foundation of Hainan Province (2017CXTD011, 817365); Key Research and Development Program of Hainan Province (ZDYF2016111)

Corresponding Authors: Xingwu Zhong, Hainan Eye Hospital and Key Laboratory of Ophthalmology,Zhongshan Ophthalmic Center, Sun Yat-sen University, Haikou, 570311, China (Email: zhongxwu@mail.sysu.edu.cn)

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	Chi Zhang
	Hui Ding
	Xiaolian Chen
	Zhenduo Yang
	Xingwu Zhong

Cite this article:

Chi Zhang,Hui Ding,Xiaolian Chen等. Comparison of short-term Changes in Dry Eye Indexes between Femtosecond Lenticule Extraction and small Incision Lenticule Extraction[J]. Chinese Journal of Optometry Ophthalmology and Visual science, 2018, 20(12): 725-730.

URL:

https://www.cjoovs.com/EN/10.3760/cma.j.issn.1674-845X.2018.12.005 OR https://www.cjoovs.com/EN/Y2018/V20/I12/725

[6]	Müller LJ, Marfurt CF, Kruse F, et al. Corneal nerves: structure,contents and function. Exp Eye Res, 2003, 76(5): 521-542.
[7]	Raoof D, Pineda R. Dry eye after laser in-situ keratomileusis.Semin Ophthalmol, 2014, 29(5-6): 358-362. DOI: 10.3109/08820538.2014.962663.
[8]	Dastjerdi MH, Dana R. Corneal nerve alterations in dry eye-associated ocular surface disease. Int Ophthalmol Clin, 2009,49(1): 11-20. DOI: 10.1097/IIO.0b013e31819242c9.
[9]	Salomão MQ, Ambrósio R, Wilson SE. Dry eye associated with laser in situ keratomileusis: Mechanical microkeratome versus femtosecond laser. J Cataract Refract Surg, 2009, 35(10): 1756-1760. DOI: 10.1016/j.jcrs.2009.05.032.
[10]	Huang JC, Sun CC, Chang CK, et al. Effect of hinge position on corneal sensation and dry eye parameters after femtosecond laser-assisted LASIK. J Refract Surg, 2012, 28(9): 625-631.DOI: 10.3928/1081597X-20120815-07.
[11]	陈祥菲, 王春红, 杨丽萍, 等. SMILE、飞秒激光制瓣LASIK及去瓣机械法LASIK术后干眼参数的比较. 中华眼视光学与视觉科学杂志, 2014, 16(9): 532-536. DOI: 10.3760/cma.j.issn.
	Ophthalmol Suppl, 1989, 192: 80-90.
[1]	Ambrósio R, Tervo T, Wilson SE. LASIK-associated dry eye and neurotrophic epitheliopathy: pathophysiology and strategies for prevention and treatment. J Refract Surg, 2008, 24(4): 396-407.
[2]	Vestergaard A, Ivarsen A, Asp S, et al. Femtosecond (FS) laser vision correction procedure for moderate to high myopia: a prospective study of ReLEx ( ® ) flex and comparison with a retrospective study of FS-laser in situ keratomileusis. Acta Ophthalmol, 2013, 91(4): 355-362. DOI: 10.1111/j.1755-3768.2012.02406.x.
16	74-845X.2014.09.005.
[12]	赵春焕, 郑坤坤, 梅波, 等. 飞秒激光制瓣的LASIK与SMILE术后干眼参数的Meta分析. 中华眼视光学与视觉科学杂志,2016, 18(6): 347-352. DOI: 10.3760/cma.j.issn.1674-845X.
[6]	Müller LJ, Marfurt CF, Kruse F, et al. Corneal nerves: structure,contents and function. Exp Eye Res, 2003, 76(5): 521-542.
[7]	Raoof D, Pineda R. Dry eye after laser in-situ keratomileusis.Semin Ophthalmol, 2014, 29(5-6): 358-362. DOI: 10.3109/08820538.2014.962663.
[8]	Dastjerdi MH, Dana R. Corneal nerve alterations in dry eye-associated ocular surface disease. Int Ophthalmol Clin, 2009,49(1): 11-20. DOI: 10.1097/IIO.0b013e31819242c9.
[9]	Salomão MQ, Ambrósio R, Wilson SE. Dry eye associated with laser in situ keratomileusis: Mechanical microkeratome versus femtosecond laser. J Cataract Refract Surg, 2009, 35(10): 1756-1760. DOI: 10.1016/j.jcrs.2009.05.032.
[10]	Huang JC, Sun CC, Chang CK, et al. Effect of hinge position on corneal sensation and dry eye parameters after femtosecond laser-assisted LASIK. J Refract Surg, 2012, 28(9): 625-631.DOI: 10.3928/1081597X-20120815-07.
[11]	陈祥菲, 王春红, 杨丽萍, 等. SMILE、飞秒激光制瓣LASIK及去瓣机械法LASIK术后干眼参数的比较. 中华眼视光学与视觉科学杂志, 2014, 16(9): 532-536. DOI: 10.3760/cma.j.issn.
[3]	Sekundo W, Kunert K, Russmann C, et al. First efficacy and safety study of femtosecond lenticule extraction for the correction of myopia: six-month results. J Cataract Refract Surg,
20	08, 34(9): 1513-1520. DOI: 10.1016/j.jcrs.2008.05.033.
20	16.06.006.
16	74-845X.2014.09.005.
[12]	赵春焕, 郑坤坤, 梅波, 等. 飞秒激光制瓣的LASIK与SMILE术后干眼参数的Meta分析. 中华眼视光学与视觉科学杂志,2016, 18(6): 347-352. DOI: 10.3760/cma.j.issn.1674-845X.
[4]	Muller LJ, Pels L, Vrensen GF. Ultrastructural organization of human corneal nerves. Invest Ophthalmol Vis Sci, 1996, 37(4):476-488.
[13]	Wilson SE. Inflammation: a unifying theory for the origin of dry eye syndrome. Manag Care, 2003, 12(12 Suppl): 14-19.
20	16.06.006.
[5]	Ueda S, del CM, LoCascio JA, et al. Peptidergic and catecholaminergic fibers in the human corneal epithelium. An immunohistochemical and electron microscopic study. Acta
[14]	Battat L, Macri A, Dursun D, et al. Effects of laser in situ keratomileusis on tear production, clearance, and the ocular surface. Ophthalmology, 2001, 108(7): 1230-1235.
[13]	Wilson SE. Inflammation: a unifying theory for the origin of dry eye syndrome. Manag Care, 2003, 12(12 Suppl): 14-19.
	Ophthalmol Suppl, 1989, 192: 80-90.
[15]	Pflugfelder SC. Tear fluid influence on the ocular surface. Adv Exp Med Biol, 1998, 438: 611-617.
[14]	Battat L, Macri A, Dursun D, et al. Effects of laser in situ keratomileusis on tear production, clearance, and the ocular surface. Ophthalmology, 2001, 108(7): 1230-1235.
[6]	Müller LJ, Marfurt CF, Kruse F, et al. Corneal nerves: structure,contents and function. Exp Eye Res, 2003, 76(5): 521-542.
[7]	Raoof D, Pineda R. Dry eye after laser in-situ keratomileusis.Semin Ophthalmol, 2014, 29(5-6): 358-362. DOI: 10.3109/08820538.2014.962663.
[8]	Dastjerdi MH, Dana R. Corneal nerve alterations in dry eye-associated ocular surface disease. Int Ophthalmol Clin, 2009,49(1): 11-20. DOI: 10.1097/IIO.0b013e31819242c9.
[9]	Salomão MQ, Ambrósio R, Wilson SE. Dry eye associated with laser in situ keratomileusis: Mechanical microkeratome versus femtosecond laser. J Cataract Refract Surg, 2009, 35(10): 1756-1760. DOI: 10.1016/j.jcrs.2009.05.032.
[10]	Huang JC, Sun CC, Chang CK, et al. Effect of hinge position on corneal sensation and dry eye parameters after femtosecond laser-assisted LASIK. J Refract Surg, 2012, 28(9): 625-631.DOI: 10.3928/1081597X-20120815-07.
[11]	陈祥菲, 王春红, 杨丽萍, 等. SMILE、飞秒激光制瓣LASIK及去瓣机械法LASIK术后干眼参数的比较. 中华眼视光学与视觉科学杂志, 2014, 16(9): 532-536. DOI: 10.3760/cma.j.issn.
[16]	Pflugfelder SC, Jones D, Ji Z, et al. Altered cytokine balance in the tear fluid and conjunctiva of patients with Sjogren's syndrome keratoconjunctivitis sicca. Curr Eye Res, 1999, 19(3):201-211.
[17]	Yoon KC, Jeong IY, Park YG, et al. Interleukin-6 and tumor necrosis factor-alpha levels in tears of patients with dry eye syndrome. Cornea, 2007, 26(4): 431-437. DOI: 10.1097/ICO.
[15]	Pflugfelder SC. Tear fluid influence on the ocular surface. Adv Exp Med Biol, 1998, 438: 611-617.
16	74-845X.2014.09.005.
[12]	赵春焕, 郑坤坤, 梅波, 等. 飞秒激光制瓣的LASIK与SMILE术后干眼参数的Meta分析. 中华眼视光学与视觉科学杂志,2016, 18(6): 347-352. DOI: 10.3760/cma.j.issn.1674-845X.
0b	013e31803dcda2.
[16]	Pflugfelder SC, Jones D, Ji Z, et al. Altered cytokine balance in the tear fluid and conjunctiva of patients with Sjogren's syndrome keratoconjunctivitis sicca. Curr Eye Res, 1999, 19(3):201-211.
[17]	Yoon KC, Jeong IY, Park YG, et al. Interleukin-6 and tumor necrosis factor-alpha levels in tears of patients with dry eye syndrome. Cornea, 2007, 26(4): 431-437. DOI: 10.1097/ICO.
20	16.06.006.
[18]	Jones DT, Monroy D, Ji Z, et al. Sjögren's syndrome: cytokine and Epstein-Barr viral gene expression within the conjunctival epithelium. Invest Ophthalmol Vis Sci, 1994, 35(9): 3493-3504.
0b	013e31803dcda2.
[13]	Wilson SE. Inflammation: a unifying theory for the origin of dry eye syndrome. Manag Care, 2003, 12(12 Suppl): 14-19.
[19]	Zoukhri D, Hodges RR, Byon D, et al. Role of proinflammatory cytokines in the impaired lacrimation associated with autoimmune xerophthalmia. Invest Ophthalmol Vis Sci, 2002,
[18]	Jones DT, Monroy D, Ji Z, et al. Sjögren's syndrome: cytokine and Epstein-Barr viral gene expression within the conjunctival epithelium. Invest Ophthalmol Vis Sci, 1994, 35(9): 3493-3504.
43	(5): 1429-1436.
[14]	Battat L, Macri A, Dursun D, et al. Effects of laser in situ keratomileusis on tear production, clearance, and the ocular surface. Ophthalmology, 2001, 108(7): 1230-1235.
[19]	Zoukhri D, Hodges RR, Byon D, et al. Role of proinflammatory cytokines in the impaired lacrimation associated with autoimmune xerophthalmia. Invest Ophthalmol Vis Sci, 2002,
[20]	Thompson HW, Beuerman RW, Cook J, et al. Transcription of message for tumor necrosis factor-alpha by lacrimal gland is regulated by corneal wounding. Adv Exp Med Biol, 1994, 350:211-217.
43	(5): 1429-1436.
[15]	Pflugfelder SC. Tear fluid influence on the ocular surface. Adv Exp Med Biol, 1998, 438: 611-617.
[20]	Thompson HW, Beuerman RW, Cook J, et al. Transcription of message for tumor necrosis factor-alpha by lacrimal gland is regulated by corneal wounding. Adv Exp Med Biol, 1994, 350:211-217.
[16]	Pflugfelder SC, Jones D, Ji Z, et al. Altered cytokine balance in the tear fluid and conjunctiva of patients with Sjogren's syndrome keratoconjunctivitis sicca. Curr Eye Res, 1999, 19(3):201-211.
[17]	Yoon KC, Jeong IY, Park YG, et al. Interleukin-6 and tumor necrosis factor-alpha levels in tears of patients with dry eye syndrome. Cornea, 2007, 26(4): 431-437. DOI: 10.1097/ICO.
0b	013e31803dcda2.
[18]	Jones DT, Monroy D, Ji Z, et al. Sjögren's syndrome: cytokine and Epstein-Barr viral gene expression within the conjunctival epithelium. Invest Ophthalmol Vis Sci, 1994, 35(9): 3493-3504.
[19]	Zoukhri D, Hodges RR, Byon D, et al. Role of proinflammatory cytokines in the impaired lacrimation associated with autoimmune xerophthalmia. Invest Ophthalmol Vis Sci, 2002,
43	(5): 1429-1436.
[20]	Thompson HW, Beuerman RW, Cook J, et al. Transcription of message for tumor necrosis factor-alpha by lacrimal gland is regulated by corneal wounding. Adv Exp Med Biol, 1994, 350:211-217.