Corvis ST评估高度近视患者角膜生物力学参数及其相关因素

doi:10.3760/cma.j.issn.1674-845X.2019.03.007

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Abstract

Objective: To evaluate the corneal biomechanical properties in high myopia using corneal visualization Scheimpflug technology (Corvis ST) and the correlation between corneal biomechanical parameters and intraocular pressure (IOP), axial length (AL), central corneal thickness (CCT), age, and retinal nerve fiber layer thickness. Methods: This was a cross-sectional study. From June to October 2017, 53 patients with high myopia were recruited from Eye Hospital, Wenzhou Medical University. The right eyes of all patients were tested. There were 17 males and 36 females, with a mean age of 33.0±9.6 years (range 18-53 years). Corvis ST was used to obtain the corneal biomechanical parameters, including velocity at the first applanation (A1V), length at the first applanation (A1L), velocity at the second applanation (A2V), length at the second applanation (A2L), deformation amplitude at the highest concavity (DA), radius at the highest concavity (HCR), and peak distance at the highest concavity (PD). The differences in corneal biomechanical parameters were compared between high myopia (-6 D to -10 D, 23 eyes) and extremely high myopia (≤-10 D, 30 eyes). Data were analyzed using independent t test and Pearson correlation.Results: There was a significant difference in A2L (t=1.95, P=0.043) between the high myopia group and extremely high myopia group. There was a negative correlation between IOP and A1V, PD, DA (r=-0.56, -0.46, -0.63, P<0.001) and a positive correlation between IOP and A2V (r=0.37, P=0.005). There was a positive correlation between PD and AL (r=0.43, P=0.001). A1L, A2L, A2V were positively correlated with CCT (r=0.33, P=0.043; r=0.28, P=0.041; r=0.39, P=0.003). PD was negatively correlated with inferior RNFL thickness (r=-0.45, P=0.001). All parameters had no significant correlation with age. Conclusions:Corneal biomechanical parameters in high myopia are positively correlated with AL and CCT, and negatively correlated with IOP and RNFL thickness, suggesting that cornea of high myopia deformed easily, and the inferior RNFL is easily affected.

Key words： axial length high myopia corneal biomechanics

Received: 15 June 2018

Corresponding Authors: Fan Lu

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[1]	中华医学会眼科学分会眼视光学组. 重视高度近视防控的专
	家共识(2017). 中华眼视光学与视觉科学杂志, 2017, 19(7):
38	5-389. DOl: 10.3760/cma.j.issn.1674-845X.2017.07.001.
[2]	Resnikoff S, Pascolini D, Mariotti SP, et al. Global magnitude
	of visual impairment caused by uncorrected refractive errors in
20	04. Bull World Health Organ, 2008, 86(1): 63-70.
[3]	Wang Y, Xu L, Jonas JB. Prevalence and causes of visual field
	loss as determined by frequency doubling perimetry in urban
	and rural adult Chinese. Am J Ophthalmol, 2006, 141(6): 1078-
10	86. DOl: 10.1016/j.ajo.2006.01.023.
[4]	Tonnu PA, Ho T, Newson T, et al. The influence of central
	corneal thickness and age on intraocular pressure measured by
	pneumotonometry, non-contact tonometry, the Tono-Pen XL,
	and Goldmann applanation tonometry. Br J Ophthalmol, 2005,
89	(7): 851-854. DOI: 10.1016/j.ajo.2006.01.023.
[5]	Broman AT, Congdon NG, Bandeen-Roche K, et al. Influence
	of corneal structure, corneal responsiveness, and other
	ocular parameters on tonometric measurement of intraocular
	pressure. J Glaucoma, 2007, 16(7): 581-588. DOI: 10.1097/
	IJG.0b013e3180640f40.
[6]	Wang W, Du S, Zhang X. Corneal deformation response in
	patients with primary open-angle glaucoma and in healthy
	subjects analyzed by Corvis ST. Invest Ophthalmol Vis Sci,
20	15, 56(9): 5557-5565. DOI: 10.1167/iovs.15-16926.
[7]	Metzler KM, Mahmoud AM, Liu J, et al. Deformation response
	of paired donor corneas to an air puff: Intact whole globe versus
	mounted corneoscleral rim. J Cataract Refract Surg, 2014, 40(6):
88	8-896. DOI: 10.1016/j.jcrs.2014.02.032.
[8]	Dupps WJ, Jr. Hysteresis: New mechanospeak for the
	ophthalmologist. J Cataract Refract Surg, 2007, 33(9): 1499-
15	01. DOI: 10.1016/j.jcrs.2007.07.008.
[9]	Doughty MJ, Zaman ML. Human corneal thickness and its
	impact on intraocular pressure measures: A review and metaanalysis
	approach. Surv Ophthalmol, 2000, 44(5): 367-408.
[10]	Del Buey MA, Lavilla L, Ascaso FJ, et al. Assessment of
	corneal biomechanical properties and intraocular pressure in
	myopic spanish healthy population. J Ophthalmol, 2014, 2014:
90	5129. DOI: 10.1155/2014/905129.
[11]	Wang J, Li Y, Jin Y, et al. Corneal biomechanical properties in
	myopic eyes measured by a dynamic Scheimpflug analyzer. J
	Ophthalmol, 2015, 2015: 161869. DOI: 10.1155/2015/161869.
[12]	He M, Wang W, Ding H, et al. Corneal biomechanical properties
	in high myopia measured by dynamic Scheimpflug imaging
	technology. Optom Vis Sci, 2017, 94(12): 1074-1080. DOI:
10	1097/OPX.0000000000001152.
[13]	Holden BA, Fricke TR, Wilson DA, et al. Global prevalence
	of myopia and high myopia and temporal trends from 2000
	through 2050. Ophthalmology, 2016, 123(5): 1036-1042. DOI:
10	1016/j.ophtha.2016.01.006.
[14]	Gentle A, Liu YY, Martin JE, et al. Collagen gene expression
	and the altered accumulation of scleral collagen during the
	development of high myopia. J Bio Chem, 2003, 278(19):
16	587-16594. DOI: 10.1074/jbc.M300970200.
[15]	Rada JA, Brenza HL. Increased latent gelatinase activity in the
	sclera of visually deprived chicks. Invest Ophthalmol Vis Sci,
19	95, 36(8): 1555-1565.
[16]	Mcbrien NA, Jobling AI, Gentle A. Biomechanics of the sclera
	in myopia: extracellular and cellular factors. Optom Vis Sci,
20	09, 86(1): E23-30. DOI: 10.1097/OPX.0b013e3181940669.
[17]	Mcbrien NA, Cornell LM, Gentle A. Structural and ultrastructural
	changes to the sclera in a mammalian model of high myopia. Invest
	Ophthalmol Vis Sci, 2001, 42(10): 2179-2187.
[18]	Curtin BJ, Karlin DB. Axial length measurements and fundus
	changes of the myopic eye. Am J Ophthalmol, 1971, 71(1 Pt 1):
42	-53.
[19]	Lee JY, Sung KR, Han S, et al. Effect of myopia on the
	progression of primary open-angle glaucoma. Invest Ophthalmol
	Vis Sci, 2015, 56(3): 1775-1781. DOI: 10.1167/iovs.14-16002.
[20]	Chang RT, Singh K. Myopia and glaucoma: Diagnostic and
	therapeutic challenges. Curr Opin Ophthalmol, 2013, 24(2): 96-
10	1. DOI: 10.1097/ICU.0b013e32835cef31.
[21]	Elsheikh A, Joda A, Abass A, et al. Assessment of the ocular
	response analyzer as an instrument for measurement of intraocular pressure and corneal biomechanics. Curr Eye Res,
20	15, 40(11): 1111-1119. DOI: 10.3109/02713683.2014.978479.
[22]	Hong J, Xu J, Wei A, et al. A new tonometer--the Corvis ST
	tonometer: clinical comparison with noncontact and Goldmann
	applanation tonometers. Invest Ophthalmol Vis Sci, 2013, 54(1):
65	9-665. DOI: 10.1167/iovs.12-10984.
[23]	Lopes BT, Roberts CJ, Elsheikh A, et al. Repeatability and
	reproducibility of intraocular pressure and dynamic corneal
	response parameters assessed by the Corvis ST. J Ophthalmol,
20	17, 2017: 8515742. DOI: 10.1155/2017/8515742.
[24]	祖培培, 王雁, 左彤, 等. 角膜生物力学眼压分析仪Corvis ST
	测量值的重复性与一致性研究. 中华眼视光学与视觉科学
	杂志, 2013, 15(5): 261-265. DOI: 10.3760/cma.j.issn.1674-
84	5X.2013.05.002.
[25]	Lee R, Chang RT, Wong IY, et al. Assessment of corneal
	biomechanical parameters in myopes and emmetropes using
	the Corvis ST. Clin Exp Optom, 2016, 99(2): 157-162. DOI:
10	1111/cxo.12341.
[26]	Elsheikh A, Geraghty B, Rama P, et al. Characterization of
	age-related variation in corneal biomechanical properties.
	J R Soc Interface, 2010, 7(51): 1475-1485. DOI: 10.1098/
	rsif.2010.0108.
[27]	Singh D, K Mishra S, Agarwal E, et al. Assessment of retinal
	nerve fiber layer changes by Cirrus high-definition optical
	coherence tomography in myopia. J Curr Glaucoma Pract, 2017,
11	(2): 52-57. DOI: 10.5005/jp-journals-10028-1223.
[28]	Kimura Y, Hangai M, Morooka S, et al. Retinal nerve fiber
	layer defects in highly myopic eyes with early glaucoma. Invest
	Ophthalmol Vis Sci, 2012, 53(10): 6472-6478. DOI: 10.1167/
	iovs.12-10319.
[29]	Wang XG, Dong J, Pu YL, et al. Comparison axial length
	measurements from three biometric instruments in high
	myopia. Int J Ophthalmol, 2016, 9(6): 876-880. DOI: 10.18240/
	ijo.2016.06.15.
[30]	Shen P, Zheng Y, Ding X, et al. Biometric measurements in
	highly myopic eyes. J Cataract Refract Surg, 2013, 39(2): 180-
18	7. DOI: 10.1016/j.jcrs.2012.08.064.
[31]	Salouti R, Nowroozzadeh MH, Zamani M, et al. Comparison
	of the ultrasonographic method with 2 partial coherence
	interferometry methods for intraocular lens power calculation.
	Optometry, 2011, 82(3): 140-147. DOI: 10.1016/j.optm.2010.07.
	025.