近视与糖尿病视网膜病变的相关性

doi:10.3760/cma.j.cn115909-20191029-00294

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Abstract Objective: To investigate the association between myopia and diabetic retinopathy (DR) using the bilateral asymmetry of the DR level. Methods: This was a cross-sectional study. The DR and diabetic macular edema (DME) levels of patients from Fushun Diabetic Retinopathy Cohort Study (FS-DIRECT) were classified according to the standards of the early treatment diabetic retinopathy study (ETDRS). The DR levels included no DR, mild nonproliferative DR (NPDR), moderate NPDR, severe NPDR, and proliferative DR (PDR). A total of 388 patients (776 eyes) with bilateral asymmetry of the DR level (at least 1 level, 314 patients, 628 eyes), or with unilateral DME (74 patients, 148 eyes) were enrolled. Myopia and high myopia were defined as spherical equivalent (SE) <-1 D and <-5 D, respectively. Paired t-tests were used to compare the SE between the better eyes and worse eyes, and the McNemar paired tests were used to compare the proportion of myopia and high myopia between the better eyes and worse eyes. Results: The mean age of these 388 patients was 60.6±8.5 years, and 147 were males (37.9%). The majority of bilateral asymmetry of the DR level was one level (297, 76.5%). The SE of the better eye was more myopic (-0.22±2.24 D vs. 0.00±1.95 D, t=3.01, P=0.003), and the proportion of high myopia was higher (4.4% and 2.1%, χ2 =6.23, P=0.01) than that of the contralateral eye. When classified according to the DR level of the better eye, the SE of the better eye among NPDR patients was more myopic (-0.37±2.76 D vs. 0.14±1.89 D, t=2.57, P=0.01), and the proportion of high myopia was higher (7.8% and 1.1%, χ2 =6.00, P=0.01) than that of the contralateral eye. There was no significant difference in refractive parameters between the better eyes and worse eyes in patients without DR or DME. Conclusions: The present study further confirms the negative association between high myopia and DR by using the bilateral asymmetry of the DR level.

Key words： diabetic retinopathy myopia high myopia

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Fund: Zhejiang Provincial Natural Science Foundation of China (LQ18H120004); Wenzhou Basic Medical and Health Technology Project (Y20190632)

Corresponding Authors: Gang Zhai, Fushun Eye Hospital, Fushun 113006, China (Email: fsyanbing@163.com)

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https://www.cjoovs.com/EN/10.3760/cma.j.cn115909-20191029-00294 OR https://www.cjoovs.com/EN/Y2020/V22/I9/702

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