严重活动期早产儿视网膜病变患儿氧疗情况及相关疾病分析

doi:10.3760/cma.j.cn115909-20200414-00149

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Abstract Objective: To analyze the oxygen therapy and neonatal-related diseases in severe, active retinopathy of prematurity (ROP). Methods: This was a case control study. Preterm infants born in the neonatal medical center of Qingdao Women and Children's Hospital from November 2017 to October 2019 were enrolled, and their fundus examination and oxygen therapy were recorded at 4-6 weeks after birth or 32 weeks of corrected gestational age. Patients were divided into a mild group and severe group based on the severity of the disease. A χ2 test was used to compare the incidence between the two groups, and a t test or MannWhitney U test was used to compare the measurement data between the two groups. Results: A total of 464 preterm infants were included in the study; 426 infants (91.8%) were in the mild group with normal or mildly active ROP, and 38 infants (8.2%) were in the severe group with severely active ROP. In the 337 premature infants receiving oxygen therapy, the duration of oxygen therapy in the severe group was significantly longer than that in mild group (Z=-7.074, P<0.001). There was no significant difference in oxygen concentration or oxygen inhalation mode between the two groups. However, the use of mechanical ventilation was more frequent in the severe group (Z=4.114, P=0.043). By analyzing the diseases of all premature infants, we found that the incidence of neonatal respiratory distress syndrome (NRDS), and neonatal bronchopulmonary dysplasia (NBPD) was higher in the severe group (χ2 =14.515, P<0.001; χ2 =4.601, P<0.032). Multivariate regression analysis showed that the duration of oxygen therapy was an independent risk factor (χ2 =18.127, P<0.001). Conclusions: A longer duration of oxygen therapy and frequent use of mechanical ventilation increased the incidence of severe, active ROP. Neonatal asphyxia, NRDS and NBPD were more common in severe ROP. The duration of oxygen therapy, oxygen supply mode and oxygen concentration were the risk factors for serious, active ROP.

Key words： retinal diseases preterm infants oxygen therapy asphyxia respiratory distress syndrome

Received: 14 April 2020

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Fund: Projects of Medical and Health Technology Development Program in Shandong Province (2016WS0298)

Corresponding Authors: Dianqiang Guo, Department of Ophthalmology, Qingdao Women and Children's Hospital, Qingdao 266034, China (Email: gdqeye@163.com)

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https://www.cjoovs.com/EN/10.3760/cma.j.cn115909-20200414-00149 OR https://www.cjoovs.com/EN/Y2020/V22/I10/769

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