早产儿及早产儿视网膜病变患儿的屈光状态及视神经纤维层厚度分析

doi:10.3760/cma.j.cn115909-20200110-00008

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Abstract Objective: To compare the refractive status and retinal nerve fiber layer thickness (RNFLT) in pre-term children with or without retinopathy of prematurity (ROP) at 8 years old, and to investigate the effects of pre-term birth and ROP on refractive status and RNFLT. Methods: This was a prospective study. From January 2009 to February 2011, premature babies (average gestational age: 33.6±4.1 weeks, average birth weight: 2 099±779 g) who underwent fundus screening in the Department of Ophthalmology, Children's Hospital of Chongqing Medical University, were divided into an ROP group and pre-term ROP group (pre-term group), and full-term babies of the same age were used as controls. A total of 112 children (222 eyes) were enrolled, including 24 in the ROP group (47 eyes), 55 in the pre-term group (110 eyes), and 33 in the full-term group (65 eyes). The RNFLT, axial length (AL), and retinoscopy were examined in the three groups at the age of 8. The incidence of refractive error and the difference in RNFLT were compared. Data were analyzed using Chi-squsure test and ANOVA. Results: The incidence of myopia (χ2 =8.062, P=0.018; χ2 =3.671, P=0.036) and astigmatism (χ2 =7.758, P=0.023; χ2 =3.710, P=0.034) in the ROP group and pre-term group were higher than those in the full-term group. There was no significant difference in the incidence of hyperopia (χ2 =4.910, P=0.250). The AL of the ROP group and pre-term group was shorter than that of the full-term group (both P<0.001). The average RNFLT of the pre-term group was thinner than that of the full-term group (F=2.593, P=0.030). The temporal quadrant RNFLT of the pre-term group was thinner than that of both the full-term group (P<0.001) and ROP group (P<0.001). Conclusions: The pre-term children and children with ROP have a shorter AL at 8 years of age, and are more prone to myopia and astigmatism. ROP and prematurity affect their refractive status, but prematurity plays a major role. Prematurity and ROP have different effects on RNFLT, especially in the temporal quadrant. The abnormalities of RNFLT caused by other diseases need to be identified during the follow-up period.

Key words： premature retinopathy of prematurity refractive error retinal nerve fiber layer

Received: 10 January 2020

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Corresponding Authors: Lianhong Pi, Department of Ophthalmology, Children's Hospital of Chongqing Medical University, Ministry of Education Key Laboratory of Child Development and Disorders, National Clinical Research Center for Child Health and Disorders (Chongqing), China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Chongqing 400014, China (Email: plh123@126.com)

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https://www.cjoovs.com/EN/10.3760/cma.j.cn115909-20200110-00008 OR https://www.cjoovs.com/EN/Y2020/V22/I10/775

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