HtrA1丝氨酸蛋白酶在息肉状脉络膜血管病变发病机制中作用的研究进展

doi:10.3760/cma.j.cn115909-20200315-00091

Abstract
Figure/Table
References (36)
Related Citation (13)

Download: PDF (696 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS) Supporting Info

Guide

Abstract Polypoidal choroidal vasculopathy (PCV) is a kind of choroidal neovascular lesion characterized by reddish-orange subretinal nodule, serous or hemorrhagic pigment epithelial detachment. The exact pathogenesis of PCV is still unclear. Previous studies have found that HtrA1 serine protease plays an important role in the pathogenesis of PCV. The exploration of the role of HtrA1 in the pathogenesis of PCV is helpful to guide the clinical treatment of PCV. This paper reviews the relative research progress.

Key words： polypoidal choroidal vasculopathy HtrA1 genetics pathogenesis

Received: 15 March 2020

PACS:

Fund:

Corresponding Authors: Jun Xiao, Ophthalmic Internal Medicine, the Second Hospital of Jilin University, Changchun 130000, China (Email: srxh6896@163.com)

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors

Cite this article:

URL:

https://www.cjoovs.com/EN/10.3760/cma.j.cn115909-20200315-00091 OR https://www.cjoovs.com/EN/Y2020/V22/I10/796

[1]	刘冉, 丁小燕. 息肉样脉络膜血管病变与渗出型老年性黄斑变性的异同. 中华眼底病杂志, 2012, 28(5): 533-539. DOI: 10.3760/cma.j.issn.1005-1015.2012.05.029.
[2]	Tanaka K, Nakayama T, Yuzawa M, et al. Analysis of candidate genes for age-related macular degeneration subtypes in the Japanese population. Mol Vis, 2011, 17: 2751-2758.
[3]	Fan Q, Cheung C, Chen LJ, et al. Shared genetic variants for polypoidal choroidal vasculopathy and typical neovascular agerelated macular degeneration in East Asians. J Hum Genet, 2017, 62(12): 1049-1055. DOI: 10.1038/jhg.2017.83.
[4]	Vierkotten S, Muether PS, Fauser S. Overexpression of HTRA1 leads to ultrastructural changes in the elastic layer of Bruch's membrane via cleavage of extracellular matrix components. PLoS One, 2011, 6(8): e22959. DOI: 10.1371/journal.pone. 0022959.
[5]	Yang Z, Camp NJ, Sun H, et al. A variant of the HTRA1 gene increases susceptibility to age-related macular degeneration. Science, 2006, 314(5801): 992-993. DOI: 10.1126/science. 1133811.
[6]	Dewan A, Liu M, Hartman S, et al. HTRA1 promoter polymorphism in wet age-related macular degeneration. Science, 2006, 314(5801): 989-992. DOI: 10.1126/science.1133807.
[7]	Iejima1 D, Itabashi1 T, Kawamura1 Y, et al. HTRA1 (high-temperature requirement a serine peptidase 1) gene is transcriptionally regulated by insertion/deletion nucleotides located at the 3 prime end of the ARMS2 (age-related maculopathy susceptibility 2) gene in patients with age-related macular degeneration. J Biol Chem, 2015, 290(5): 2784-2797. DOI: 10.1074/jbc.M114.593384.
[8]	Fritsche LG, Loenhardt T, Janssen A, et al. Age-related macular degeneration is associated with an unstable ARMS2 (LOC387715) mRNA. Nat Genet, 2008, 40(7): 892-896. DOI: 10.1038/ng.170.
[9]	Yang Z, Tong Z, Chen Y, et al. Genetic and functional dissection of HTRA1 and LOC387715 in age-related macular degeneration. PLoS Genet, 2010, 6(2): e1000836. DOI: 10.1371/ journal.pgen.1000836.
[10]	Friedrich U, Myers CA, Fritsche LG, et al. Risk- and non-risk-associated variants at the 10q26 AMD locus influence ARMS2 mRNA expression but exclude pathogenic effects due to protein deficiency. Hum Mol Genet, 2011, 20(7): 1387-1399. DOI: 10.1093/hmg/ddr020.
[11]	Kanda A, Stambolian D, Chen W, et al. Age-related macular degeneration-associated variants at chromosome 10q26 do not significantly alter ARMS2 and HTRA1 transcript levels in the human retina. Mol Vis, 2010, 16: 1317-1323.
[12]	Ng TK, Liang XY, Lai TY, et al. HTRA1 promoter variant differentiates polypoidal choroidal vasculopathy from exudative age-related macular degeneration. Sci Rep, 2016, 6: 28639. DOI: 10.1038/srep28639.
[13]	Kondo N, Honda S, Ishibashi K, et al. LOC387715/HTRA1 variants in polypoidal choroidal vasculopathy and age-relatedmacular degeneration in a Japanese population. Am J Ophthalmol, 2007, 144(4): 608-612. DOI: 10.1016/j.ajo.2007.06.003.
[14]	De Luca A, De Falco M, Severino A, et al. Distribution of the serine protease HtrA1 in normal human tissues. J Histochem Cytochem, 2003, 51(10): 1279-1284. DOI: 10.1177/002215540305101004.
[15]	Haffner C. Proteostasis in cerebral small vessel disease. Front Neurosci, 2019, 13: 1142. DOI: 10.3389/fnins.2019.01142.
[16]	Yanagi Y, Foo V, Yoshida A. Asian age-related macular degeneration: from basic science research perspective. Eye (Lond), 2019, 33(1): 34-49. DOI: 10.1038/s41433-018-0225-x.
[17]	Zhang L, Lim SL, Du H, et al. High temperature requirement factor A1 (HTRA1) gene regulates angiogenesis through transforming growth factor-β family member growth differentiation factor 6. J Biol Chem, 2012, 287(2): 1520-1526. DOI: 10.1074/jbc.M111.275990.
[18]	Asai-Coakwell M, French CR, Berry KM, et al. GDF6, a novel locus for a spectrum of ocular developmental anomalies. Am J Hum Genet, 2007, 80(2): 306-315. DOI: 10.1086/511280.
[19]	Mathura JR Jr, Jafari N, Chang JT, et al. Bone morphogenetic proteins-2 and -4: negative growth regulators in adult retinal pigmented epithelium. Invest Ophthalmol Vis Sci, 2000, 41(2): 592-600.
[20]	Chen CY, Melo E, Jakob P, et al. N-Terminomics identifies HtrA1 cleavage of thrombospondin-1 with generation of a proangiogenic fragment in the polarized retinal pigment epithelial cell model of age-related macular degeneration. Matrix Biol, 2018, 70: 84-101. DOI: 10.1016/j.matbio.2018.03.013.
[21]	Runyon ST, Zhang Y, Appleton BA, et al. Structural and functional analysis of the PDZ domains of human HtrA1 and HtrA3. Protein Sci, 2007, 16(11): 2454-2471. DOI: 10.1110/ ps.073049407.
[22]	Murwantoko, Yano M, Ueta Y, et al. Binding of proteins to the PDZ domain regulates proteolytic activity of HtrA1 serine protease. Biochem J, 2004, 381(Pt 3): 895-904. DOI: 10.1042/ BJ20040435.
[23]	Grau S, Richards PJ, Kerr B, et al. The role of human HtrA1 in arthritic disease. J Biol Chem, 2006, 281(10): 6124-6129. DOI: 10.1074/jbc.M500361200.
[24]	Chien J, Ota T, Aletti G, et al. Serine protease HtrA1 associates with microtubules and inhibits cell migration. Mol Cell Biol, 2009, 29(15): 4177-4187. DOI: 10.1128/MCB.00035-09.
[25]	Melo E, Oertle P, Trepp C, et al. HtrA1 Mediated Intracellular Effects on Tubulin Using a Polarized RPE Disease Model. EBioMedicine, 2018, 27: 258-274. DOI: 10.1016/ j.ebiom.2017.12.011.
[26]	Kanda A, Chen W, Othman M, et al. A variant of mitochondrial protein LOC387715/ARMS2, not HTRA1, is strongly associated with age-related macular degeneration. Proc Natl Acad Sci USA, 2007, 104(41): 16227-16232. DOI: 10.1073/pnas.0703933104.
[27]	Kortvely E, Hauck SM, Duetsch G, et al. ARMS2 is a constituent of the extracellular matrix providing a link between familial and sporadic age-related macular degenerations. Invest Ophthalmol Vis Sci, 2010, 51(1): 79-88. DOI: 10.1167/ iovs.09-3850.
[28]	Jones A, Kumar S, Zhang N, et al. Increased expression of multifunctional serine protease, HTRA1, in retinal pigment epithelium induces polypoidal choroidal vasculopathy in mice. Proc Natl Acad Sci USA, 2011, 108(35): 14578-14583. DOI: 10.1073/pnas.1102853108.
[29]	Kumar S, Berriochoa Z, Ambati BK, et al. Angiographic features of transgenic mice with increased expression of human serine protease HTRA1 in retinal pigment epithelium. Invest Ophthalmol Vis Sci, 2014, 55(6): 3842-3850. DOI: 10.1167/ iovs.13-13111.
[30]	Jones A, Kumar S, Wang S, et al. Histopathological characterization of different lesion types of polypoidal choroidal vasculopathy in HTRA1 transgenic mice. Invest Ophthalmol Vis Sci, 2014, 55(13): 1184-1184.
[31]	Nakayama M, Iejima D, Akahori M, et al. Overexpression of HtrA1 and exposure to mainstream cigarette smoke leads to choroidal neovascularization and subretinal deposits in aged mice. Invest Ophthalmol Vis Sci, 2014, 55(10): 6514-6523. DOI: 10.1167/iovs.14-14453.
[32]	Kumar S, Nakashizuka H, Jones A, et al. Proteolytic Degradation and Inflammation Play Critical Roles in Polypoidal Choroidal Vasculopathy. Am J Pathol, 2017, 187(12): 2841- 2857. DOI: 10.1016/j.ajpath.2017.08.025.
[33]	Lu Z, Lin V, May A, et al. HTRA1 synergizes with oxidized phospholipids in promoting inflammation and macrophage infiltration essential for ocular VEGF expression. PLoS One, 2019, 14(5): e0216808. DOI: 10.1371/journal.pone.0216808.
[34]	Wong CW, Yanagi Y, Lee WK, et al. Age-related macular degeneration and polypoidal choroidal vasculopathy in Asians. Prog Retin Eye Res, 2016, 53: 107-139. DOI: 10.1016/j.preteyeres. 2016.04.002.
[35]	徐奕爽, 苏钰, 陈长征. 脉络膜增厚谱系疾病的研究现状与进展. 中华眼视光学与视觉科学杂志, 2018, 20(4): 253-256. DOI: 10.3760/cma.j.issn.1674-845X.2018.04.013.
[36]	Cheung C, Lee WK, Koizumi H, et al. Pachychoroid disease. Eye (Lond), 2019, 33(1): 14-33. DOI: 10.1038/s41433-018- 0158-4.