单纯性高度近视黄斑区视网膜敏感度与血流密度的关系

doi:10.3760/cma.j.cn115909-20200413-00146

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Abstract Objective: To study the standardized changes in retinal sensitivity and vessel density in the macular area of simple high myopia and to explore their correlations. Methods: This was a descriptive research. A total of 80 patients (80 eyes) who were treated at Nanchang Aier Eye Hospital and volunteers from March 2019 to September 2019 were included, of which 47 cases (47 eyes) were in the simple high myopia group, and 33 cases (33 eyes) were in the control group. Optical coherence tomography angiography (OCTA) was used to measure the retinal superficial vessel density (SVD) and deep vessel density (DVD) in the macular area at 3 mm×3 mm. Macular integrity assessment (MAIA) measured the retinal sensitivity (RS) in a 10° diameter of the macular area. Based on the Early Treatment Diabetic Retinopathy Study, the RS was divided into 6 regions (temporal, superior, nasal, inferior, fovea and parafovea) corresponding to the vessel. Data in each area were compared by an independent t-test between the two groups. Pearson correlation analysis was used for the correlation of RS with axial length (AL), spherical equivalent (SE), SVD and DVD. Results: RS in the high myopia group decreased significantly in all areas except the nasal area (P<0.05). The entire area and the parafoveal, superior and inferior areas of DVD in the high myopia group decreased significantly (P<0.05). Regardless of the entire group of subjects or the high myopia group, RS was positively correlated with SE (r=0.382, P<0.001; r=0.435, P=0.002), and negatively correlated with AL (r=-0.429, P<0.001; r=-0.382, P=0.008), positively correlated with DVD (r=0.286, P=0.010; r=0.344, P=0.018), and had no correlation with SVD. In the high myopia group, RS was positively correlated with SVD in the foveal, parafoveal, temporal and nasal regions (r=0.386, P=0.015; r=0.292, P=0.046; r=0.435, P=0.006; r=0.319, P=0.048). RS and DVD were positively correlated with DVD in the foveal, parafoveal, inferior and inferior regions (r=0.330, P=0.040; r=0.358, P=0.025; r=0.294, P=0.045; r=0.437, P=0.005). Conclusion: Retinal sensitivity and deep vessel density in simple high myopia decreases with regional differences. The decrease in retinal sensitivity may be related to the decrease in deep vessel density.

Key words： high myopia macular area retinal sensitivity optical coherence tomography angiography microperimetry vessel density

Received: 13 April 2020

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Corresponding Authors: Bo Ye, Aier School of Ophthalmology, Central South University, Changsha 410015, China; Nanchang Aier Eye Hospital, Nanchang 330000, China (Email: yebo814@126.com)

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[1]	Holden BA, Fricke TR, Wilson DA, et al. Global prevalence of myopia and high myopia and temporal trends from 2000 through 2050. Ophthalmology, 2016, 123(5): 1036-1042. DOI: 10.1016/ j.ophtha.2016.01.006.
[2]	Sun J, Zhou J, Zhao P, et al. High prevalence of myopia and high myopia in 5060 Chinese university students in Shanghai. Invest Ophthalmol Vis Sci, 2012, 53(12): 7504-7509. DOI: 10.1167/iovs.11-8343.
[3]	中华医学会眼科学分会眼视光学组. 重视高度近视防控的专家共识(2017). 中华眼视光学与视觉科学杂志, 2017, 19(7): 385-389. DOI: 10.3760/cma.j.issn.1674-845X.2017.07.001.
[4]	Flitcroft DI. The complex interactions of retinal, optical and environmental factors in myopia aetiology. Prog Retin Eye Res, 2012, 31(6): 622-660. DOI: 10.1016/j.preteyeres.2012.06.004.
[5]	Ikuno Y. Overview of the complications of high myopia. Retina, 2017, 37(12): 2347-2351. DOI: 10.1097/IAE. 0000000000001489.
[6]	Benavente-Pérez A, Hosking SL, Logan NS, et al. Ocular blood flow measurements in healthy human myopic eyes. Graefes Arch Clin Exp Ophthalmol, 2010, 248(11): 1587-1594. DOI: 10.1007/s00417-010-1407-9.
[7]	Azemin MZ, Daud NM, Ab Hamid F, et al. Influence of refractive condition on retinal vasculature complexity in younger subjects. Sci Wor J, 2014, 2014: 783525. DOI: 10.1155/2014/ 783525.
[8]	Fan H, Chen HY, Ma HJ, et al. Reduced macular vascular density in myopic eyes. Chin Med J (Engl), 2017, 130(4): 445- 451. DOI: 10.4103/0366-6999.199844.
[9]	Al-Sheikh M, Phasukkijwatana N, Dolz-Marco R, et al. Quantitative OCT angiography of the retinal microvasculature and the choriocapillaris in myopic eyes. Invest Ophthalmol Vis Sci, 2017, 58(4): 2063-2069. DOI: 10.1167/iovs.16-21289.
[10]	Pfau M, Lindner M, Fleckenstein M, et al. Test-Retest Reliability of Scotopic and Mesopic Fundus-Controlled Perimetry Using a Modified MAIA (Macular Integrity Assessment) in Normal Eyes. Ophthalmologica, 2017, 237(1): 42-54. DOI: 10.1159/000453079.
[11]	Cocce KJ, Stinnett SS, Luhmann U, et al. Visual function metrics in early and intermediate dry age-related macular degeneration for use as clinical trial endpoints. Am J Ophthalmol, 2018, 189: 127-138. DOI: 10.1016/j.ajo.2018.02.012.
[12]	Early Treatment Diabetic Retinopathy Study design and baseline patient characteristics. ETDRS report number 7. Ophthalmology, 1991, 98(5 Suppl): 741-756. DOI: 10.1016/ s0161-6420(13)38009-9.
[13]	Venkatesh R, Sinha S, Gangadharaiah D, et al. Retinal structuralvascular-functional relationship using optical coherence tomography and optical coherence tomography - angiography in myopia. Eye Vis (Lond), 2019, 6: 8. DOI: 10.1186/s40662-019- 0133-6.
[14]	俞素勤, 李欣馨, 许迅. OCT血流成像技术的现在与未来. 中华眼视光学与视觉科学杂志, 2017, 19(10): 577-585. DOI: 10.3760/cma.j.issn.1674-845X.2017.10.001.
[15]	Tsui CK, Yang B, Yu S, et al. The relationship between macular vessel density and thickness with light sensitivity in myopic eyes. Curr Eye Res, 2019, 44(10): 1104-1111. DOI: 10.1080/02713683.2019.1627461.
[16]	Hassan M, Sadiq MA, Halim MS, et al. Evaluation of macular and peripapillary vessel flow density in eyes with no known pathology using optical coherence tomography angiography. Int J Retina Vitreous, 2017, 3: 27. DOI: 10.1186/s40942-017-0080-0.
[17]	Lam DS, Leung KS, Mohamed S, et al. Regional variations in the relationship between macular thickness measurements and myopia. Invest Ophthalmol Vis Sci, 2007, 48(1): 376-382. DOI: 10.1167/iovs.06-0426.
[18]	Wu PC, Chen YJ, Chen CH, et al. Assessment of macular retinal thickness and volume in normal eyes and highly myopic eyes with third-generation optical coherence tomography. Eye (Lond), 2008, 22(4): 551-555. DOI: 10.1038/sj.eye.6702789.
[19]	Simorre-Pinatel V, Guerrin M, Chollet P, et al. VasculotropinVEGF stimulates retinal capillary endothelial cells through an autocrine pathway. Invest Ophthalmol Vis Sci, 1994, 35(9): 3393-3400.
[20]	Zhang M, Hwang TS, Campbell JP, et al. Projection-resolved optical coherence tomographic angiography. Biomed Opt Express, 2016, 7(3): 816-828. DOI: 10.1364/BOE.7.000816.
[21]	Qin Y, Zhu M, Qu X, et al. Regional macular light sensitivity changes in myopic Chinese adults: An MP1 study. Invest Ophthalmol Vis Sci, 2010, 51(9): 4451-4457. DOI: 10.1167/ iovs.09-4642.
[22]	Fujiwara A, Shiragami C, Manabe S, et al. Normal values of retinal sensitivity determined by macular integrity assessment. Nippon Ganka Gakkai Zasshi, 2014, 118(1): 15-21.
[23]	吴秋艳, 陈绮, 谭凡, 等. 高度近视患者黄斑区视网膜光敏感度的变化. 中华眼视光学与视觉科学杂志, 2017, 19(3): 146- 151. DOI: 10.3760/cma.j.issn.1674-845X.2017.03.005.
[24]	Zaben A, Zapata MÁ, Garcia-Arumi J. Retinal sensitivity and choroidal thickness in high myopia. Retina, 2015, 35(3): 398- 406. DOI: 10.1097/IAE.0000000000000367.
[25]	Jeong D, Sung KR, Jo YH, et al. Age-related physiologic thinning rate of the retinal nerve fiber layer in different levels of myopia. J Ophthalmol, 2020, 2020: 1873581. DOI: 10.1155/2020/1873581.
[26]	Wang XE, Wang XY, Gu YS, et al. Retinal nerve fiber layer in primary open-angle glaucoma with high myopia determined by optical coherence tomography and scanning laser polarimetry. Chin Med J (Engl), 2013, 126(8): 1425-1429.
[27]	Huynh SC, Wang XY, Rochtchina E, et al. Peripapillary retinal nerve fiber layer thickness in a population of 6-year-old children: Findings by optical coherence tomography. Ophthalmology, 2006, 113(9): 1583-1592. DOI: 10.1016/j.ophtha.2006.02.067.
[28]	Leung CK, Mohamed S, Leung KS, et al. Retinal nerve fiber layer measurements in myopia: An optical coherence tomography study. Invest Ophthalmol Vis Sci, 2006, 47(12): 5171-5176. DOI: 10.1167/iovs.06-0545.
[29]	Alzaben Z, Cardona G, Zapata MA, et al. Interocular asymmtry in choroidal thickness and retinal sensitivity in high myopia. Retina, 2018, 38(8): 1620-1628. DOI: 10.1097/ IAE.0000000000001756.
[30]	Scarinci F, Nesper PL, Fawzi AA. Deep retinal capillary nonperfusion is associated with photoreceptor disruption in diabetic macular ischemia. Am J Ophthalmol, 2016, 168: 129- 138. DOI: 10.1016/j.ajo.2016.05.002.
[31]	Scarinci F, Jampol LM, Linsenmeier RA, et al. Association of diabetic macular nonperfusion with outer retinal disruption on optical coherence tomography. JAMA Ophthalmol, 2015, 133(9): 1036-1044. DOI: 10.1001/jamaophthalmol.2015.2183.
[32]	Moon BG, Um T, Lee J, et al. Correlation between deep capillary plexus perfusion and long-term photoreceptor recovery after diabetic macular edema treatment. Ophthalmol Retina, 2018, 2(3): 235-243. DOI: 10.1016/j.oret.2017.07.003.
[33]	Lee K, Lee J, Lee CS, et al. Topographical variation of macular choroidal thickness with myopia. Acta Ophthalmol, 2015, 93(6): 469-474. DOI: 10.1111/aos.12701.
[34]	Kim TW, Kim M, Weinreb RN, et al. Optic disc change with incipient myopia of childhood. Ophthalmology, 2012, 119(1): 21-26.e1-3. DOI: 10.1016/j.ophtha.2011.07.051.