地夸磷索钠滴眼液对中重度干眼患者眼表状况和视觉质量的影响

doi:10.3760/cma.j.cn115909-20201029-00418

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Abstract Objective: To evaluate changes in the ocular surface status and the visual quality in patients with moderate to severe dry eyes before and after treatment with 3% diquafosol sodium eye drops. Methods: In this prospective clinical study, a total of 78 patients (78 eyes) with moderate to severe dry eye were included from the ophthalmic outpatient department of Renmin Hospital of Wuhan University from September 2019 to August 2020. Patients were randomly divided into two groups based on the criteria. In the artificial tear group, 38 patients (38 eyes) were treated with artificial tear drops for 3 s/d; in the diquafosol sodium group, 40 patients (40 eyes) were treated with diquafosol sodium for 6 s/d and artificial tear for 3 s/d. The therapeutic effect was observed 1 month after treatment. The data were analyzed by sample t test, Chi-square and Spearman correlation. Results: After 1 month of treatment, the two groups of patients had improved, and the effect in the diquafosol sodium group was better than that in the artificial tears group for break-up time (BUT), tear meniscus height, Schirmer Ⅰ test, corneal fluorescein staining (FL) and the tear film objective scatter index (TF-OSI) (t=2.613, P=0.029; t=8.498, P=0.001; t=4.082, P=0.015; t=15.06, P<0.001; t=5.021, P=0.007). TF-OSI was negatively correlated with BUT and Modulation transfer function cut off before and after use in the two groups (r=-0.298, P=0.045; r=-0.478, P=0.033; r=-0.478, P=0.004; r=-0.399, P=0.006), and TF-OSI was positively correlated with the dry eye questionnaire score (OSDI) and FL in the diquafosol sodium group (r=0.479, P=0.035; r=0.254, P=0.027). Conclusions: Diquafosol sodium combined with artificial tears can effectively improve the clinical symptoms and signs of moderate to severe dry eyes, and can effectively improve the visual quality of patients. This improvement is better than treatment with artificial tears alone.

Key words： moderate and severe dry eyes P2Y2 receptor tear film visual quality objective scattering index of tear film

Received: 29 October 2020

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Fund: National Natural Science Foundation of China (81770899)

Corresponding Authors: Yanning Yang, Department of Ophthalmology, Renmin Hospital of Wuhan University, Wuhan 430060, China (Email: ophyyn@163.com)

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https://www.cjoovs.com/EN/10.3760/cma.j.cn115909-20201029-00418 OR https://www.cjoovs.com/EN/Y2021/V23/I5/329

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